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  4. Bovine interleukin 4,IL-4 ELISA Kit

Bovine interleukin 4,IL-4 ELISA Kit

  • 中文名稱：
    牛白介素4(IL-4)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E12898B
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3800/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    牛白介素4(IL-4)酶聯(lián)免疫試劑盒（CSB-E12898B）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IL4含量。IL4是一個(gè)重要靶點(diǎn)。它是白細(xì)胞介素家族成員，在免疫系統(tǒng)中起關(guān)鍵作用，參與調(diào)節(jié)B細(xì)胞、T細(xì)胞等免疫細(xì)胞的生長和分化。研究機(jī)制上，主要聚焦其信號(hào)通路及與疾病發(fā)生發(fā)展關(guān)聯(lián)，圍繞它開發(fā)的藥物有望用于哮喘、特應(yīng)性皮炎等免疫相關(guān)疾病治療。試劑盒檢測范圍為12.5 pg/mL-800 pg/mL，適用于科研領(lǐng)域探究牛類感染性疾病、過敏反應(yīng)或炎癥過程中IL-4的動(dòng)態(tài)變化，例如通過血清/血漿樣本評(píng)估疫苗免疫效果，或利用組織勻漿分析特定器官的免疫應(yīng)答機(jī)制，為畜牧養(yǎng)殖中的疾病機(jī)制研究和免疫調(diào)控提供實(shí)驗(yàn)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    IL4Interleukin-4 ELISA Kit; IL-4 ELISA Kit; B-cell stimulatory factor 1 ELISA Kit; BSF-1 ELISA Kit; Lymphocyte stimulatory factor 1 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Bos taurus (Bovine)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    12.5 pg/mL-800 pg/mL
  • 靈敏度：
    3.12 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of bovine IL-4 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %95
    Range %89-99
    1:2Average %97
    Range %92-103
    1:4Average %90
    Range %85-94
    1:8Average %84
    Range %80-88
  • 回收率：
    The recovery of bovine IL-4 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9589-99
    EDTA plasma (n=4)8984-93
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    8001.993 1.912 1.953 1.835
    4001.576 1.616 1.596 1.478
    2001.304 1.354 1.329 1.211
    1000.939 0.962 0.951 0.833
    500.624 0.641 0.633 0.515
    250.441 0.419 0.430 0.312
    12.50.283 0.279 0.281 0.163
    00.119 0.117 0.118 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
  • 基因功能參考文獻(xiàn)：
    1. These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma occurring after parturition and an increase in IL-4 production before calving. PMID: 23814356
    2. IL-4 may play a role in coordinating the adrenal response to inflammatory stress. PMID: 18055157
    3. T helper (Th) type 2 cell cytokine IL-4 modulates airway contraction by secreting matrix metalloproteinase-1 from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions. PMID: 18322231
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    IL-4/IL-13 family
  • 數(shù)據(jù)庫鏈接：

    KEGG: bta:280824

    STRING: 9913.ENSBTAP00000021215

    UniGene: Bt.423