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  4. Chicken Interleukin 6,IL-6 ELISA Kit

Chicken Interleukin 6,IL-6 ELISA Kit

  • 中文名稱：
    雞白介素6(IL-6)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E08549Ch
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3800/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    雞白介素6(IL-6)酶聯(lián)免疫試劑盒（CSB-E08549Ch）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的IL6含量。IL6是一種多功能細(xì)胞因子，由多種細(xì)胞產(chǎn)生，參與免疫、炎癥和代謝等生理過(guò)程。其研究機(jī)制涉及與IL-6R結(jié)合，激活JAK/STAT3等信號(hào)通路，調(diào)節(jié)細(xì)胞生長(zhǎng)、分化和存活。IL6在多種疾病如炎癥、癌癥和自身免疫性疾病中發(fā)揮重要作用。試劑盒檢測(cè)范圍為15.6 pg/mL-1000 pg/mL，其動(dòng)態(tài)監(jiān)測(cè)對(duì)家禽免疫機(jī)制研究、疫苗效力評(píng)估及感染性疾病模型構(gòu)建具有重要意義。適用于科研實(shí)驗(yàn)中定量分析雞類樣本的IL - 6表達(dá)水平，可為家禽免疫學(xué)基礎(chǔ)研究、病原體感染機(jī)制探索及抗炎藥物開(kāi)發(fā)提供可靠數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    IL6 ELISA Kit; Interleukin-6 ELISA Kit; ChIL-6 ELISA Kit; IL-6 ELISA Kit
  • 縮寫(xiě)：
  • Uniprot No.：
  • 種屬：
    Gallus gallus (Chicken)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    15.6 pg/mL-1000 pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of chicken IL-6 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:1 Average % 93  
    Range % 85-97  
    1:2 Average % 92  
    Range % 85-99  
    1:4 Average % 95  
    Range % 89-100  
    1:8 Average % 92  
    Range % 85-100  
  • 回收率：
    The recovery of chicken IL-6 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 98 91-105  
    EDTA plasma (n=4) 96 88-99  
                 
                 
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected  
    1000 2.487 2.570 2.529 2.454  
    500 2.204 2.230 2.217 2.142  
    250 1.800 1.764 1.782 1.707  
    125 1.390 1.394 1.392 1.317  
    62.5 0.917 0.950 0.934 0.859  
    31.2 0.584 0.568 0.576 0.501  
    15.6 0.348 0.362 0.355 0.280  
    0 0.074 0.075 0.075 　  
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    IL-6是一種多功能細(xì)胞因子，可以影響許多不同類型的細(xì)胞和器官。最新研究表明，IL-6參與了許多疾病的發(fā)病機(jī)制，如自身免疫性疾病、心血管疾病、腫瘤等。此外，IL-6在新冠疫情中也扮演了重要角色，成為疫苗研究和治療的關(guān)鍵目標(biāo)之一。針對(duì)IL-6的治療方法，如抗IL-6受體抗體和抑制IL-6表達(dá)的藥物等，在臨床治療中已經(jīng)取得了一些成功。
  • 功能：
    Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
  • 基因功能參考文獻(xiàn)：
    1. Avian leukosis virus subgroup J induces VEGF expression via NF-kappaB/PI3K-dependent IL-6 production to promoter tumorigenesis. PMID: 27852059
    2. The effects of daily corticosterone injections on acute phase proteins (APP), IL-6, and HSP70 are reported; APP and HSP70 may be of value as indicators of stress in poultry. PMID: 25306460
    3. Chicken IL-6 is a heat-shock gene PMID: 24055475
    4. Nampt/visfatin/PBEF affects expression of myogenic regulatory factors and is regulated by interleukin-6 in chicken skeletal muscle cells PMID: 21545843
    5. IL-6 is involved in the progression of chicken arthritis induced by Staph. aureus, and it contributes to disease incidence and mortality PMID: 17495100

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    IL-6 superfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: gga:395337

    UniGene: Gga.2769