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  4. Goat insulin-like growth factor 1(IGF-1)ELISA Kit

Goat insulin-like growth factor 1(IGF-1)ELISA Kit

  • 中文名稱：
    山羊胰島素樣生長因子1(IGF-1)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E15909G
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥4200/￥3000
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    山羊胰島素樣生長因子1(IGF-1)酶聯(lián)免疫試劑盒（CSB-E15909G）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IGF1含量。IGF1，即胰島素樣生長因子1，是一種由肝臟分泌的蛋白質(zhì)，與生長激素協(xié)同作用，促進(jìn)細(xì)胞生長、增殖和分化。其研究機(jī)制涉及IGF1與IGF-1R（胰島素樣生長因子受體）的結(jié)合，通過PI3K/AKT和MEK/ERK等信號(hào)通路調(diào)控細(xì)胞功能。IGF1在多種生理和病理過程中發(fā)揮重要作用，包括生長發(fā)育、腫瘤發(fā)生和內(nèi)耳保護(hù)等。試劑盒檢測范圍為62.5 ng/ml-1000 ng/ml.，本試劑盒適用于畜牧科學(xué)研究、動(dòng)物生理調(diào)控機(jī)制探索、營養(yǎng)代謝實(shí)驗(yàn)及疾病模型分析等領(lǐng)域，為評(píng)估山羊生長性能、研究激素調(diào)控網(wǎng)絡(luò)提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    IGF1Insulin-like growth factor I ELISA Kit; IGF-I ELISA Kit; Somatomedin ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Capra hircus (Goat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    62.5 ng/ml-1000 ng/ml.
  • 靈敏度：
    12.5 ng/ml.
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1.
  • 基因功能參考文獻(xiàn)：
    1. Relative expression of IGF1 was highest in uterus and liver (P < 0.05), followed by oviduct and muscle. This work provided an important experimental basis for further research on the functions of IGF1 in goats. PMID: 28674230
    2. These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs. PMID: 26852275
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Insulin family
  • 組織特異性：
    Expressed in all tissues examined: brain, lung, liver, spleen, uterus, ovary, testis, heart and skeletal muscle.
  • 數(shù)據(jù)庫鏈接：

    KEGG: chx:100860838

    UniGene: Chi.6376