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  4. Horse insulin-like growth factor 1 (IGF1) ELISA kit

Horse insulin-like growth factor 1 (IGF1) ELISA kit

  • 中文名稱(chēng)：
    馬胰島素樣生長(zhǎng)因子1(IGF1)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL011086HO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥4200/￥3000
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    馬胰島素樣生長(zhǎng)因子1(IGF1)酶聯(lián)免疫試劑盒（CSB-EL011086HO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的IGF1含量。IGF1即胰島素樣生長(zhǎng)因子 1，在人體生長(zhǎng)發(fā)育、細(xì)胞增殖分化等生理過(guò)程中發(fā)揮重要作用。其異常表達(dá)與癌癥、糖尿病等疾病密切相關(guān)。研究機(jī)制多聚焦于它與受體結(jié)合激活下游信號(hào)通路，以探索通過(guò)干預(yù)該靶點(diǎn)治療相關(guān)疾病的策略。試劑盒檢測(cè)范圍為12.5 ng/mL-800 ng/mL，適用于馬屬動(dòng)物相關(guān)的基礎(chǔ)研究，如運(yùn)動(dòng)生理學(xué)分析、生長(zhǎng)調(diào)控機(jī)制探索、代謝性疾病模型構(gòu)建等科研領(lǐng)域本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    IGF1 ELISA Kit; Insulin-like growth factor I ELISA Kit; IGF-I ELISA Kit; Somatomedin ELISA Kit; Fragment ELISA Kit
  • 縮寫(xiě)：
  • Uniprot No.：
  • 種屬：
    Equus caballus (Horse)
  • 樣本類(lèi)型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    12.5 ng/mL-800 ng/mL
  • 靈敏度：
    3.12 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of horse IGF1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %92
    Range %89-95
    1:2Average %95
    Range %90-104
    1:4Average %92
    Range %87-100
    1:8Average %89
    Range %80-97
  • 回收率：
    The recovery of horse IGF1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9587-101
    EDTA plasma (n=4)8782-93
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    8001.961 1.944 1.953 1.820
    4001.488 1.605 1.547 1.414
    2001.178 1.213 1.196 1.063
    1000.912 0.902 0.907 0.774
    500.669 0.657 0.663 0.530
    250.405 0.396 0.401 0.268
    12.50.260 0.249 0.255 0.122
    00.137 0.129 0.133
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1.
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Insulin family
  • 數(shù)據(jù)庫(kù)鏈接：