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  4. Human αN-acetylglucosaminidase,αNAG ELISA Kit

Human αN-acetylglucosaminidase,αNAG ELISA Kit

  • 中文名稱：
    人αN已酰氨基葡糖苷酶(αNAG)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E09456h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人αN已酰氨基葡糖苷酶(αNAG)酶聯(lián)免疫試劑盒（CSB-E09456h）為競(jìng)爭(zhēng)法ELISA試劑盒，定量檢測(cè)樣本中的NAGLU含量。NAGLU 是一個(gè)重要靶點(diǎn)。它與多種生理和病理過(guò)程相關(guān)，在人體代謝等方面發(fā)揮關(guān)鍵作用。目前研究聚焦于其在疾病發(fā)生發(fā)展中的機(jī)制，比如某些遺傳疾病與之關(guān)聯(lián)，通過(guò)深入研究其作用機(jī)制有望開(kāi)發(fā)出針對(duì)性的治療藥物和手段。適用于細(xì)胞生物學(xué)、病理機(jī)制研究及藥物開(kāi)發(fā)中酶活性變化的動(dòng)態(tài)監(jiān)測(cè)，可為代謝性疾病模型構(gòu)建、基因功能驗(yàn)證等實(shí)驗(yàn)提供可靠數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    Alpha N acetylglucosaminidase ELISA Kit; alpha N acetylglucosaminidase; lysosomal ELISA Kit; Alpha-N-acetylglucosaminidase 77 kDa form ELISA Kit; ANAG ELISA Kit; ANAG_HUMAN ELISA Kit; CMT2V ELISA Kit; MPS IIIB ELISA Kit; MPS3B ELISA Kit; N acetyl alpha glucosaminidase ELISA Kit; N acetylglucosaminidase; alpha ELISA Kit; N-acetyl-alpha-glucosaminidase ELISA Kit; NAG ELISA Kit; NAGLU ELISA Kit; UFHSD 1 ELISA Kit; UFHSD ELISA Kit; UFHSD1 ELISA Kit
  • 縮寫(xiě)：
    NAGLU
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
  • 檢測(cè)范圍：
  • 靈敏度：
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Competitive
  • 精密度：
  • 線性度：
  • 回收率：
  • 標(biāo)準(zhǔn)曲線：
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the degradation of heparan sulfate.
  • 基因功能參考文獻(xiàn)：
    1. findings show that the NAGLU protein consists of a precursor and a mature form and that in slowly progressing mucopolysaccharidosis type IIIB patients' fibroblasts only the precursor protein is present at 37 degrees ; culturing at lower temperatures resulted in the formation of the mature, enzymatically active form, due to higher mRNA levels and improved processing PMID: 28751108
    2. CSF enzyme activity levels for either SGSH (in MPS IIIA subjects) or NAGLU (in MPS IIIB) significantly differed from normal controls. Several other behavioral or functional measures were found to be uninformative in this population, including timed functional motor tests. PMID: 27590925
    3. Mutation in NAGLU gene is associated with atypical mucopolysaccharidosis IIIB. PMID: 28306536
    4. in the current meta-analysis, based on ten prospective studies involving 29366 participants, we evaluated the role of urinary tubular injury markers (NGAL, KIM-1 and NAG) in predicting clinical outcomes including CKD stage 3, end stage renal disease and mortality. PMID: 27907168
    5. Mutations in NAGLU gene is associated with idiopathic progressive cognitive decline. PMID: 25466957
    6. Plasma NAG correlates with gastrointestinal cancer outcomes. PMID: 25040106
    7. study reports that carriers from two families of a severe pathogenic mutation in NAGLU develop a late dominant painful axonal sensory neuropathy. PMID: 25818867
    8. A modified recombinant NAGLU fused to the receptor-binding motif of insulin-like growth factor (IGF)-II enhances its ability to enter cells using the mannose 6-phosphate receptor, which is the receptor for IGF-II at a different binding site. PMID: 24266751
    9. The research may enrich the mutation spectrum of the NAGLU gene in the Chinese population and help us further in understanding the pathogenesis of MPS IIIB. PMID: 23380547
    10. Urinary NAG/Cr may be a useful surrogate marker for renal function in ADPKD patients. PMID: 22935351
    11. This study suggests a possible role of NAGLU in susceptibility to PD while extending evidence for alpha-synuclein aggregation in the brain in lysosomal storage disorders. PMID: 22102531
    12. We have identified an 1146 bp intragenic deletion of the NAGLU gene within consanguineous parents having two children affected with Sanfilippo syndrome type B. PMID: 20138557
    13. Molecular genetics of mucopolysaccharidosis type IIIA and IIIB: Diagnostic, clinical, and biological implications PMID: 11668611
    14. Sanfilippo syndrome (subtypes A and B) in Turkey: identification of novel mutations in SGSH and NAGLU PMID: 11793481
    15. The NAGLU gene in 11 Mucopolysaccharidosis type IIIB Portuguese patients, was examined, having identified five novel (M1K, W147X, G304V, S522P, and R533X) and four previously reported mutations (W168X, R234C, R565W and R643C). PMID: 18218046

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  • 相關(guān)疾病：
    Mucopolysaccharidosis 3B (MPS3B); Charcot-Marie-Tooth disease 2V (CMT2V)
  • 亞細(xì)胞定位：
    Lysosome.
  • 蛋白家族：
    Glycosyl hydrolase 89 family
  • 組織特異性：
    Liver, ovary, peripheral blood leukocytes, testis, prostate, spleen, colon, lung, placenta and kidney.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 7632

    OMIM: 252920

    KEGG: hsa:4669

    STRING: 9606.ENSP00000225927

    UniGene: Hs.50727