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  4. Human A disintegrin and metalloproteinase with thrombospondin motifs 18(ADAMTS18) ELISA kit

Human A disintegrin and metalloproteinase with thrombospondin motifs 18(ADAMTS18) ELISA kit

  • 中文名稱：
    人金屬肽酶含血小板反應(yīng)蛋白18(ADAMTS18)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL001306HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人金屬肽酶含血小板反應(yīng)蛋白18(ADAMTS18)酶聯(lián)免疫試劑盒（CSB-EL001306HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的ADAMTS18含量。ADAMTS18屬于ADAMTS蛋白酶家族，參與細胞外基質(zhì)的代謝和組織重塑。研究表明，它在多種生理和病理過程中發(fā)揮作用，如血管生成、腫瘤進展等。其機制可能涉及對特定底物的蛋白水解切割，不過關(guān)于它的確切功能和作用機制仍在進一步研究中。試劑盒檢測范圍為0.016ug/ml- 10ug/ml，支持科研領(lǐng)域?qū)DAMTS18蛋白表達的定量分析，適用于癌癥生物學研究、組織微環(huán)境調(diào)控、胚胎發(fā)育或疾病模型構(gòu)建等方向，為探索ADAMTS18在細胞遷移、血管形成或腫瘤轉(zhuǎn)移中的作用機制提供可靠工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    ADAMTS18 ELISA kit; ADAMTS21A disintegrin and metalloproteinase with thrombospondin motifs 18 ELISA kit; ADAM-TS 18 ELISA kit; ADAM-TS18 ELISA kit; ADAMTS-18 ELISA kit; EC 3.4.24.- ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.016ug/ml- 10ug/ml
  • 靈敏度：
    0.016ug/ml
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻：
    1. In summary, we demonstrate that ADAMTS18 silencing in breast cancer is significantly correlated with promoter CpG methylation. ADAMTS18 acts as an antagonist of AKT and NF-kappaB signaling, further suppressing EMT and metastasis of breast cancer cells. PMID: 28503860
    2. This study showed that ADAMTS1, 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer) PMID: 28814085
    3. Studies suggest that ADAM metallopeptidase with thrombospondin type 1 motif, 18 protein (ADAMTS-18) as a promising diagnostic and therapeutic target. PMID: 24896365
    4. Novel homozygous mutations in ADAMTS18 were identified, consisting of c.1067T>A [p.L356*] in the first proband, c.2159G>C [p.C720S] in the 2 affected brothers PMID: 24874986
    5. Results suggest that ADAMTS18 plays an essential role in early eye development and that mutations therein cause a distinct eye phenotype that is mainly characterized by microcornea and myopia. PMID: 23818446
    6. study reveals that mutations in the ADAMTS18 gene can cause a broad phenotypic spectrum of eye disorders and contribute to shed further light on the complexity of retinal diseases PMID: 23356391
    7. the study identified ADAMTS18 as the only gene carrying a homozygous protein altering mutation. PMID: 21862674
    8. ADAMTS18 mutations promote growth, migration, and metastasis in melanoma PMID: 21047771
    9. ADAMTS18 gene methylation in 3 types of cancers was significantly higher than normal tissues. No significant association was found between methylation status & TNM staging. Epigenetic regulation of ADAMTS18 was associated with carcinogenesis. PMID: 19806480
    10. Functional epigenetics show ADAMTS18 to be a novel functional tumor suppressor, being frequently inactivated epigenetically in multiple carcinomas. PMID: 17546048
    11. ADAMTS18 and TGFBR3 might underlie BMD determination in the major human ethnic groups. PMID: 19249006

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  • 相關(guān)疾?。?/div>
    Microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT)
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 組織特異性：
    Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17110

    OMIM: 607512

    KEGG: hsa:170692

    STRING: 9606.ENSP00000282849

    UniGene: Hs.188746