搡老女人多毛老妇女中国,日韩亚洲欧美中文高清在线,人妻少妇一区二区三区,色妞色综合久久夜夜,日本熟妇xxxx

  1. 首頁
  2. 試劑盒
  3. 酶聯(lián)免疫試劑盒
  4. Human Angiopoietin-1(ANGPT1) ELISA kit

Human Angiopoietin-1(ANGPT1) ELISA kit

  • 中文名稱：
    人血管生成素1(ANGPT1)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL001706HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人血管生成素1(ANGPT1)酶聯(lián)免疫試劑盒（CSB-EL001706HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿、組織培養(yǎng)上清液樣本中的ANGPT1含量。ANGPT1是一個(gè)重要靶點(diǎn)。它在血管生成、維持血管穩(wěn)定等生理過程中發(fā)揮關(guān)鍵作用。其研究機(jī)制主要圍繞與受體結(jié)合，激活下游信號(hào)通路，調(diào)控內(nèi)皮細(xì)胞行為。深入了解它有助于揭示相關(guān)疾病發(fā)病機(jī)制，并為開發(fā)治療藥物提供理論依據(jù)。試劑盒檢測(cè)范圍為1.25 ng/mL-80 ng/mL，靈敏度為0.091 ng/mL。適用于血管生物學(xué)機(jī)制研究、腫瘤微環(huán)境分析、心血管疾病模型構(gòu)建等科研場(chǎng)景，可幫助研究者探索ANGPT1在血管生成異常、炎癥反應(yīng)或器官纖維化等病理過程中的表達(dá)調(diào)控規(guī)律，為體外實(shí)驗(yàn)或動(dòng)物模型中的血管相關(guān)研究提供可靠的數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell culture supernates
  • 檢測(cè)范圍：
    1.25 ng/mL-80 ng/mL
  • 靈敏度：
    0.091 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：

     

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

     

  • 線性度：

     

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

     

  • 標(biāo)準(zhǔn)曲線：

     

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

     

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
        最近的研究表明，ANGPT1在調(diào)節(jié)血管通透性和血管生成方面發(fā)揮著重要作用。它的缺失可能導(dǎo)致血管滲漏和心血管疾病等疾病的發(fā)生。最近的研究還發(fā)現(xiàn)，ANGPT1可以作為一種潛在的治療靶點(diǎn)，用于治療多種疾病，如腫瘤、心血管疾病和腎病等。
  • 功能：
    Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
  • 亞細(xì)胞定位：
    Secreted.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 484

    OMIM: 601667

    KEGG: hsa:284

    STRING: 9606.ENSP00000428340

    UniGene: Hs.369675