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  4. Human Ankyrin repeat domain-containing protein 26(ANKRD26) ELISA kit

Human Ankyrin repeat domain-containing protein 26(ANKRD26) ELISA kit

  • 中文名稱：
    人錨蛋白重復(fù)結(jié)構(gòu)域蛋白26(ANKRD26)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL001763HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人錨蛋白重復(fù)結(jié)構(gòu)域蛋白26(ANKRD26)酶聯(lián)免疫試劑盒（CSB-EL001763HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的ANKRD26含量。ANKRD26是一個受關(guān)注的靶點。其它在人體生理過程可能扮演重要角色。研究機(jī)制上，具體作用機(jī)制仍在探索，可能參與細(xì)胞內(nèi)一些信號傳導(dǎo)通路等，深入研究它有望為相關(guān)疾病的發(fā)病機(jī)制、診斷及治療提供新思路。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，適用于細(xì)胞分化、造血調(diào)控機(jī)制等基礎(chǔ)研究，或疾病模型中ANKRD26表達(dá)動態(tài)變化的定量分析；為腫瘤生物學(xué)、血液病理學(xué)等科研領(lǐng)域提供可靠工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Ankrd26 ELISA Kit; Ankyrin repeat domain 26 ELISA Kit; Ankyrin repeat domain-containing protein 26 ELISA Kit; Ankyrin repeat domaincontaining protein 26 ELISA Kit; ANR26_HUMAN ELISA Kit; bA145E8.1 ELISA Kit; KIAA1074 ELISA Kit
  • 縮寫：
    ANKRD26
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human ANKRD26 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 90
    Range % 87-93
    1:2 Average % 102
    Range % 98-106
    1:4 Average % 85
    Range % 80-91
    1:8 Average % 104
    Range % 101-108
  • 回收率：
    The recovery of human ANKRD26 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 99 95-103
    EDTA plasma (n=4) 86 83-89
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    2000 2.126 2.201 2.164 2.039
    1000 1.671 1.658 1.665 1.540
    500 1.135 1.204 1.170 1.045
    250 0.696 0.685 0.691 0.566
    125 0.464 0.471 0.468 0.343
    62.5 0.318 0.320 0.319 0.194
    31.25 0.241 0.249 0.245 0.120
    0 0.126 0.124 0.125 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior.
  • 基因功能參考文獻(xiàn)：
    1. in a cohort of patients with suspected familial thrombocytopenia, the c.-140C>G mutation seems to be the most frequent ANKRD26 mutation. PMID: 28277066
    2. Two cases with mutant ANKRD26 highlight that patients with thrombocytopenia 2 are at risk of being misdiagnosed with myelodysplastic syndrome and receiving undue myelosuppressive treatments. Because dysmegakaryopoiesis is a feature also of other forms of inherited thrombocytopenia, a genetic disorder must always be considered when a patient presents with isolated thrombocytopenia and dysmegakaryopoiesis. PMID: 28976612
    3. investigation of one patient with the c.3G>A showed that mutation was associated with strong ANKRD26 overexpression in vivo, which is the proposed mechanism for predisposition to AML in THC2 patients PMID: 28100250
    4. The findings of lifelong thrombocytopenia with mild/absent bleeding, family history of thrombocytopenia with normal platelet size and myeloid neoplasms should raise the suspicion of ANKRD26 mutated thrombocytopenia. PMID: 27123948
    5. Molecular analysis identified a mutation located in the promoter of the ankyrin repeat domain 26 (ANKRD26) gene, c.-127A>T in normocytic thrombocytopenia. PMID: 27108925
    6. thrombocytopenia with 5'UTR ANKRD26 gene mutation must be considered in case of a constitutional isolated thrombocytopenia, with a low bleeding tendency, associated with autosomal dominant transmission and normal platelet volume. PMID: 25902755
    7. WASP, RUNX1, and ANKRD26 genes are important for normal TPO signaling and the network underlying thrombopoiesis. PMID: 26175287
    8. The study supports the association of ANKRD26 mutations with thrombocytopenia 2 and a predisposition to myeloid malignancies. PMID: 24628296
    9. ANKRD26 regulatory region mutations induce MAPK hyperactivation in familial thrombocytopenia PMID: 24430186
    10. the missense mutations may paly a role in the pathogenesis of Autosomal-dominant nonsyndromic thrombocytopenia-2 PMID: 23869080
    11. Studies indicate that ANKRD26-RT is an insidious form of inherited thrombocytopenias that exposes patients to a low risk of bleeding but predisposes them to hematologic myeloid malignancies. PMID: 24030261
    12. Ubiquitin/proteasome-rich particulate cytoplasmic structures are a characteristic feature of ANKRD26-related thrombocytopenia platelets and megakaryocytes. PMID: 23223974
    13. The ANKRD26-related thrombocytopenia has to be taken into consideration in the differential diagnosis of isolated thrombocytopenias. PMID: 21467542
    14. mutations in the 5' UTR of ANKRD26 are implicated in thrombocytopenia 2. PMID: 21211618

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  • 相關(guān)疾病：
    Thrombocytopenia 2 (THC2)
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29186

    OMIM: 188000

    KEGG: hsa:22852

    STRING: 9606.ENSP00000365255

    UniGene: Hs.361041