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  4. Human Anterior gradient protein 3 homolog(AGR3) ELISA kit

Human Anterior gradient protein 3 homolog(AGR3) ELISA kit

  • 中文名稱：
    人前梯度蛋白3同源物(AGR3)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL001459HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人前梯度蛋白3同源物(AGR3)酶聯(lián)免疫試劑盒（CSB-EL001459HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的AGR3含量。AGR3是一種與促癌基因AGR2高度相關(guān)的同源蛋白，屬于蛋白質(zhì)二硫鍵異構(gòu)酶家族。它在乳腺癌、卵巢癌、前列腺癌和肝癌中表達，與腫瘤的分化程度、增殖速度和預(yù)后相關(guān)。研究顯示，AGR3在乳腺癌患者中表達與更長的無進展生存期和更好的預(yù)后相關(guān)。其具體作用機制尚在研究中，但可能與蛋白質(zhì)折疊和巰基-二硫化物交換反應(yīng)有關(guān)。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，本試劑盒可應(yīng)用于科研領(lǐng)域中對AGR3蛋白表達量的精準檢測，適用于腫瘤發(fā)生機制研究、疾病相關(guān)分子標(biāo)志物篩選、藥物干預(yù)效果評估等實驗場景。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    AG-3 ELISA Kit; AG3 ELISA Kit; Agr3 ELISA Kit; AGR3_HUMAN ELISA Kit; Anterior gradient 3; xenopus; homolog of ELISA Kit; Anterior gradient homolog 3 ELISA Kit; Anterior gradient homolog 3 (Xenopus laevis) ELISA Kit; anterior gradient protein 3 ELISA Kit; Anterior gradient protein 3 homolog ELISA Kit; BCMP11 ELISA Kit; Breast cancer membrane protein 11 ELISA Kit; Gm888 ELISA Kit; hAG 3 ELISA Kit; hAG-3 ELISA Kit; HAG3 ELISA Kit; OTTHUMP00000158512 ELISA Kit; PDIA18 ELISA Kit; Protein disulfide isomerase family A member 18 ELISA Kit
  • 縮寫：
    AGR3
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human AGR3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %85
    Range %80-89
    1:2Average %91
    Range %86-95
    1:4Average %94
    Range %90-98
    1:8Average %97
    Range %92-101
  • 回收率：
    The recovery of human AGR3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9085-95
    EDTA plasma (n=4)9489-99
  • 標(biāo)準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    102.713 2.662 2.688 2.515
    52.376 2.431 2.404 2.231
    2.51.934 2.001 1.968 1.795
    1.251.509 1.582 1.546 1.373
    0.6250.974 1.020 0.997 0.824
    0.3120.564 0.559 0.562 0.389
    0.1560.296 0.279 0.288 0.115
    00.178 0.167 0.173 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.
  • 基因功能參考文獻：
    1. Results show that AGR3 was highly upregulated in low-grade serous carcinoma (LGSC) compared to high-grade serous carcinoma (HGSC). It can be use along with p53 for differential diagnosis of HGSC and LGSC. PMID: 29620196
    2. transcriptionally activated in hepatitis C virus-infected cells by HCV NS5A PMID: 25868611
    3. Data show the potential usability of anterior gradient homolog 3 (AGR3) and anterior gradient homolog 2 (AGR2) as biomarkers for blood-based early detection of breast cancer. PMID: 25875093
    4. AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway. PMID: 25751668
    5. Relying on available data and in silico analyses, study shows that AGR2 and AGR3 proteins are co-expressed or uncoupled in context-dependent manners in diverse carcinomas and healthy tissues. PMID: 25666661
    6. AGR3 was is predominantly expressed in liver cholangiocytes but not present in liver hepatocytes, making this protain a good marker for differential diagnosis of intrahepatic cholangiocarcinoma PMID: 24747240
    7. AGR3 expression in ovarian cancer is independent of oestrogen-receptor expression. PMID: 22361111
    8. AGR3 could serve as a prognostic marker for survival in patients with low grade and high grade serous ovarian carcinomas. PMID: 21451362
    9. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan [hAG-3 protein] PMID: 12592373
    10. specific induction of Hag2 and Hag3 during hormone-induced breast carcinomas further support developmental specificity for the PDI/ERp family members PMID: 15935701

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  • 亞細胞定位：
    Endoplasmic reticulum.
  • 蛋白家族：
    AGR family
  • 組織特異性：
    Expressed in the lung, in the ciliated cells of the airway epithelium. Expression increased with differentiation of airway epithelial cells. Not detected in the mucous cells. Expressed in ciliated cells in the oviduct. Also detected in stomach, colon, pro
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24167

    OMIM: 609482

    KEGG: hsa:155465

    STRING: 9606.ENSP00000308606

    UniGene: Hs.100686