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  4. Human B-cell differentiation antigen CD72(CD72) ELISA kit

Human B-cell differentiation antigen CD72(CD72) ELISA kit

  • 中文名稱：
    人B細胞分化蛋白CD72(CD72)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL004955HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人B細胞分化蛋白CD72(CD72)酶聯(lián)免疫試劑盒（CSB-EL004955HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CD72含量。CD72是重要靶點，它是B細胞表面糖蛋白，在B細胞發(fā)育、活化及免疫調(diào)節(jié)中起關鍵作用。研究機制方面，聚焦于其與配體相互作用，通過信號通路影響B(tài)細胞功能，針對它的研究有望為免疫相關疾病如自身免疫病、腫瘤等治療帶來新策略。試劑盒檢測范圍為0.9 ng/mL-60 ng/mL，適用于科研領域探究B細胞相關免疫機制，如系統(tǒng)性紅斑狼瘡、類風濕性關節(jié)炎等自身免疫疾病模型中的B細胞功能研究，或腫瘤微環(huán)境中B淋巴細胞活化狀態(tài)的分子機制分析，為免疫調(diào)控網(wǎng)絡研究提供定量檢測方案。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    CD72; B-cell differentiation antigen CD72; Lyb-2; CD antigen CD72
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.9 ng/mL-60 ng/mL
  • 靈敏度：
    0.225 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human CD72 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 98
    Range % 92-103
    1:2 Average % 91
    Range % 86-98
    1:4 Average % 92
    Range % 88-97
    1:8 Average % 101
    Range % 96-15
  • 回收率：
    The recovery of human CD72 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 90 87-95
    EDTA plasma (n=4) 101 103-106
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    60 2.588 2.787 2.688 2.535
    30 2.169 2.236 2.203 2.050
    15 1.674 1.744 1.709 1.556
    7.5 1.322 1.223 1.273 1.120
    3.75 0.752 0.744 0.748 0.595
    1.8 0.363 0.375 0.369 0.216
    0.9 0.261 0.255 0.258 0.105
    0 0.149 0.156 0.153 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in B-cell proliferation and differentiation.
  • 基因功能參考文獻：
    1. Interferon-alpha-induced CD100 expression on naive CD8(+) T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction. PMID: 28222623
    2. Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis PMID: 26883681
    3. CD72 expression on activated B cells of SLE patients was significantly lower than that of normal controls. sema3A enhanced CD72 expression of B cells, but it was still lower in SLE patients than in normal individuals. PMID: 24461079
    4. data demonstrated aberrant expression of CD72 exists on B cells of myasthenia gravis and multiple sclerosis patients and expression level of CD72 molecule has a significantly negative correlation with anti-AchR antibody levels in myasthenia gravis PMID: 23184497
    5. regulates serum immunoglobulin leveln and disease resistance in systemic lupus erythematosus PMID: 23268649
    6. CD72 mRNA expression level correlates with Sema4D expression in peripheral blood mononuclear cells in immune thrombocytopenia. PMID: 22111667
    7. CD100, CD72 and CD45 were expressed in placenta and exhibited different mRNA and protein levels in normal pregnancy and miscarriage. Protein levels were highly dysregulated around 10 weeks of gestation in first and second miscarriage placentas. PMID: 22606231
    8. CD100-CD72 interaction can be the mechanism by which NK cell communicate with B cells. PMID: 17786190
    9. Data show that ligation of CD72 with the BU40, or with rCD100 negatively regulates KIT-mediated mast cell proliferation, chemotaxis, and chemokine production. PMID: 20100931
    10. results indicated that the presence of CD72-*2 allele decreases risk for human systemic lupus erythematosus conferred by FCGR2B-232Thr, possibly by increasing the AS isoform of CD72 PMID: 15459183
    11. CD72 is a key molecule in regulating mature B cell differentiation; CD72 signaling reduces the expression of X-box binding protein 1 in B cells PMID: 16047337
    12. increased nucleotide mutation of CD72 mRNA accounts for the decreased expression level of CD72 in B cells, and it might be related to hyperactivity of B cells in patients with SLE PMID: 17121583
    13. CD72 polymorphisms are associated with age of appearing clinical manifestations in idiopathic thrombocytopenic purpura in Chinese patients. PMID: 18071878

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  • 亞細胞定位：
    Membrane; Single-pass type II membrane protein.
  • 組織特異性：
    Pre-B-cells and B-cells but not terminally differentiated plasma cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1696

    OMIM: 107272

    KEGG: hsa:971

    STRING: 9606.ENSP00000259633

    UniGene: Hs.116481