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  4. Human Beta-microseminoprotein (MSMB/PRSP) ELISA kit

Human Beta-microseminoprotein (MSMB/PRSP) ELISA kit

  • 中文名稱：
    人β-微精原蛋白 (MSMB/PRSP)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E17126h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人β-微精原蛋白 (MSMB/PRSP)酶聯(lián)免疫試劑盒（CSB-E17126h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的MSMB含量。MSMB 是重要的靶點(diǎn)。它在前列腺等組織中表達(dá)，與腫瘤等疾病密切相關(guān)。研究機(jī)制方面，聚焦于其在信號傳導(dǎo)通路里的作用，以及對細(xì)胞增殖、凋亡等過程的影響，探索其作為疾病診斷標(biāo)志物和治療靶點(diǎn)的可能性。試劑盒檢測范圍為2.5 ng/mL-80 ng/mL，本試劑盒可用于基礎(chǔ)醫(yī)學(xué)研究中MSMB/PRSP的表達(dá)水平檢測，如前列腺疾病機(jī)制研究、腫瘤相關(guān)生物標(biāo)志物探索、體外細(xì)胞模型蛋白分泌分析等場景，也可應(yīng)用于組織樣本中蛋白表達(dá)的定量比較實(shí)驗(yàn)。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Beta microseminoprotein [Precursor] ELISA Kit; Beta-microseminoprotein ELISA Kit; HPC 13 ELISA Kit; HPC13 ELISA Kit; IGBF ELISA Kit; Immunoglobulin binding factor ELISA Kit; Immunoglobulin-binding factor ELISA Kit; microseminoprotein beta ELISA Kit; Msmb ELISA Kit; MSMB_HUMAN ELISA Kit; MSP ELISA Kit; MSPB ELISA Kit; PN 44 ELISA Kit; PN44 ELISA Kit; Prostate secreted seminal plasma protein ELISA Kit; Prostate secretory protein of 94 amino acids ELISA Kit; Prostate secretory protein PSP94 ELISA Kit; PRPS ELISA Kit; PRSP ELISA Kit; PSP 57 ELISA Kit; PSP ELISA Kit; PSP-94 ELISA Kit; PSP57 ELISA Kit; PSP94 ELISA Kit; Seminal plasma beta inhibin ELISA Kit; Seminal plasma beta-inhibin ELISA Kit
  • 縮寫：
    MSMB
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    2.5 ng/mL-80 ng/mL
  • 靈敏度：
    1.25 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<15%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<20%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human MSMB in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %91
    Range %85-97
    1:2Average %96
    Range %90-102
    1:4Average %93
    Range %86-100
    1:8Average %95
    Range %86-101
  • 回收率：
    The recovery of human MSMB spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9590-100
    EDTA plasma (n=4)9288-96
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2Average
    802.243 2.268 2.256
    401.369 1.352 1.361
    200.672 0.663 0.668
    50.204 0.194 0.199
    2.50.092 0.095 0.094
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. Studies indicate prostate secretory protein of 94 amino acids (PSP94) as a prostate tumor marker [Review]. PMID: 28930560
    2. this meta-analysis indicates that MSMB gene rs10993994 polymorphism increases the risk of PC. PMID: 28212531
    3. PSP94 levels differed among idiopathic pulmonary fibrosis, pulmonary sarcoidosis and chronic pulmonary obstructive disease. PMID: 27758987
    4. Results identified CRISP2 as a potential binding protein of PSP94 from human sperm. PMID: 27161017
    5. decreased expression of MSMB parallels the clinical progression of PC and adjusted serum MSMB levels are associated with PC risk PMID: 26939004
    6. Based on nasopharyngeal MSP gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants. PMID: 25261323
    7. PSP94 regulate the Lin28/Let-7 loop in ovarian cancer cells. PMID: 25188517
    8. Data indicate that prostate secretory protein PSP94 is decreased in an ovarian cancer drug-resistant cell line, and plays an important role in the development of drug resistance in vitro. PMID: 24186202
    9. The rs10993994 genotype in the MSMB gene modifies the association between number of sexual partners and prostate cancer risk. PMID: 24037734
    10. Beta-microseminoprotein in urine was statistically lower in prostate cancer patients. PMID: 24115268
    11. Han Chinese men carrying the MSMB variant have an increased risk of spermatogenic failure associated with male infertility. PMID: 23608167
    12. Data indicate that the increase in prostate cancer (PC) risk associated with rs10993994:C>T is likely mediated by the variant's effect of MSMB-encoded protein PSP94 expression; however, this effect does not extend to NCOA4 in the data. PMID: 22887727
    13. Involvement of the hinge region of CRISPs in interaction with PSP94 may affect the domain movement of CRISPs essential for the ion-channel regulatory activity resulting in inhibition of this activity. PMID: 23375721
    14. MSMB and CRISP3 were widely distributed in ovaries and in ovarian tumors; the expression of MSMB fits well with a tumor-suppressor function in ovarian carcinogenesis. PMID: 22993349
    15. Computational network analysis reveals that the MSMB gene is functionally connected to NCOA4 and the androgen receptor signaling pathway. The data provide an example of how GWAS-associated variants may have multiple genetic and epigenetic effects PMID: 22661295
    16. These data identify beta-microseminoprotein as an important innate immune factor active against C. albicans and may help explain the low sexual transmission rate of Candida. PMID: 22496651
    17. MSMB is a strong independent factor, predicting favorable outcome after radical prostatectomy for localized prostate cancer. PMID: 21240253
    18. provide the first link between a low penetrance polymorphism for prostate cancer and a potential test in human tissue and bodily fluids PMID: 20967219
    19. Suppression of MSMB expression or NCOA4 overexpression promotes anchorage-independent growth of prostate epithelial cells. PMID: 21085629
    20. Authors examines the association between rs10993994 genotype and MSP levels in a sample of 500 prostate cancer-free men from four racial/ethnic populations in the Multiethnic Cohort (European Americans, African Americans, Latinos, and Japanese Americans). PMID: 20736317
    21. MSMB expression is influenced by androgens, but also by genotype and epigenetic silencing. PMID: 20680031
    22. Either PSP94 or CRISP-3 alone can induce growth inhibition in prostate cancer cells in a cell line specific manner. PMID: 20676114
    23. High MSMB expression is associated with the development of prostate cancer. PMID: 20569440
    24. SNPs at MSMB correlate with physiologic variation in beta-MSP and PSA levels in the blood and semen of healthy young Swedish men. In particular, rs10993994 has a strong effect on beta-MSP levels. PMID: 20696662
    25. A single-nucleotide polymorphism in the MSMB promoter contributes to the genetic predisposition to prostate cancer in the southern Chinese Han population. PMID: 20333697
    26. Crystal structure shows that these edges from two PSP94 monomers associate in antiparallel fashion, leading to formation of a dimer. PMID: 20184897
    27. We conclude that MSMB is unlikely to be a familial prostate cancer gene.The high-risk alleles may effect prostate cancer risk by modifying MSMB gene expression in response to hormones in a tissue-specific manner. PMID: 19997100
    28. Ab initio structure of human seminal plasma prostatic inhibin gives significant insight into its biological functions. PMID: 12032598
    29. a new blood protein (PSPBP) is identified that binds PSP94 PMID: 15344909
    30. NMR solution structure PMID: 16930619
    31. Bound/free PSP94 is a novel and independent prognostic markers following radical prostatectomy for prostate cancer. PMID: 17062675
    32. Our data disclose a hitherto unexplored link between the putative oncogene EZH2 and the tumor suppressor PSP94, and show that MSMB is silenced by EZH2 in advanced prostate cancer cells. PMID: 17237810
    33. both native PSP94 as well as modified protein have the ability to bind human IgG, suggesting the involvement of sequential epitopes of PSP94 in IgG binding PMID: 17493883
    34. Predictor of recurrence after radical prostatectomy for localized prostate cancer. PMID: 17634540
    35. MSP in serum can be used as a marker of prostate secretion, despite the contribution from extra prostatic tissues. PMID: 18222915
    36. A tentative structure for the hMSP-CRISP-3 complex using the known crystal structure of triflin as a model of CRISP-3 was presented. PMID: 19026612
    37. alternative splicing variants, M-RIP, HYAL2, CDCA1, and MSMB genes showed differential expressions between cancer cells and corresponding normal tissues. PMID: 19081476
    38. The observations that rs10993994 is the strongest associated variant in the region and its risk allele has a major effect on the transcriptional activity of MSMB suggest the T allele as a causal variant that confers increased risk of prostate cancer. PMID: 19153072
    39. PSP94 has been purified from human seminal plasma and crystallized. PMID: 19342788
    40. a common variant in MSMB on chromosome 10q11.2 is associated with prostate cancer susceptibility PMID: 19383797
    41. beta-Microseminoprotein was purified using anion-exchange and size-exclusion chromatography and the purified protein was crystallized using 0.1 M ammonium sulfate, 0.1 M HEPES buffer pH 7.0 and 20%(w/v) PEG 3350 PMID: 19407392
    42. For the two SNPs that had significant differences between more and less aggressive disease, KLK3 and MSMB, the alleles that are associated with increased risk for prostate cancer were more frequent in patients with less aggressive disease. PMID: 19434657

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  • 相關(guān)疾病：
    Prostate cancer, hereditary, 13 (HPC13)
  • 亞細(xì)胞定位：
    Secreted. Note=Sperm surface.
  • 蛋白家族：
    Beta-microseminoprotein family
  • 組織特異性：
    Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney an
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7372

    OMIM: 157145

    KEGG: hsa:4477

    STRING: 9606.ENSP00000351363

    UniGene: Hs.255462