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  4. Human Bone morphogenetic protein 3(BMP3) ELISA kit

Human Bone morphogenetic protein 3(BMP3) ELISA kit

  • 中文名稱：
    人骨形態(tài)發(fā)生蛋白3(BMP3)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL002739HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人骨形態(tài)發(fā)生蛋白3(BMP3)酶聯(lián)免疫試劑盒（CSB-EL002739HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的BMP3含量。人骨形態(tài)發(fā)生蛋白3（BMP3）是一種轉化生長因子-β超家族成員，具有誘導骨和軟骨發(fā)育的能力。它通過負向調節(jié)骨密度，在成骨祖細胞分化中作為其他BMP的拮抗劑，并在骨折組織中高度表達。BMP3的研究揭示了其在骨再生和發(fā)育中的重要作用。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL，適用于體外實驗模型、動物研究或疾病機制探索中BMP3蛋白動態(tài)變化的檢測，如骨發(fā)育相關基因調控研究、再生醫(yī)學中成骨分化評估或代謝性疾病生物標志物分析等領域，為深入解析BMP3在生理病理過程中的功能提供可靠工具本品僅用于科研，不用于臨床診斷，產品具體參數(shù)及操作步驟詳見產品說明書。
  • 別名：
    BMP-3 ELISA Kit; BMP-3A ELISA Kit; bmp3 ELISA Kit; BMP3_HUMAN ELISA Kit; BMP3A ELISA Kit; Bone morphogenetic protein 3 (osteogenic) ELISA Kit; Bone morphogenetic protein 3 ELISA Kit; Bone morphogenetic protein 3A ELISA Kit; Osteogenin ELISA Kit
  • 縮寫：
    BMP3
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    15.6 pg/mL-1000 pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human BMP3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 88
    Range % 82-91
    1:2 Average % 102
    Range % 97-106
    1:4 Average % 94
    Range % 87-98
    1:8 Average % 93
    Range % 86-97
  • 回收率：
    The recovery of human BMP3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 104 99-108
    EDTA plasma (n=4) 92 87-96
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    1000 2.512 2.633 2.573 2.399
    500 1.834 1.948 1.891 1.717
    250 1.176 1.218 1.197 1.023
    125 0.756 0.774 0.765 0.591
    62.5 0.463 0.473 0.468 0.294
    31.2 0.289 0.296 0.293 0.119
    15.6 0.225 0.235 0.230 0.056
    0 0.173 0.175 0.174 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways.
  • 基因功能參考文獻：
    1. This study demonstrated that there was a significantly higher frequency of BMP3 methylated DNA in plasma in patients with polyps versus healthy controls with a sensitivity and specificity of 40 and 94%, respectively. PMID: 29892846
    2. BMP3 - the biomarker of a currently in-use multi-target stool DNA test was commonly expressed in tumor tissue specimens, independent of Fecal Immunochemical Test result. PMID: 28044229
    3. Methylation level in stool decreases dramatically following colorectal cancer resection PMID: 24993691
    4. Bone morphogenic protein 3 signaling in the regulation of osteogenesis. PMID: 23127436
    5. As an addition to PRKG2 and RASGEFIB genes, we propose to include BMP3 gene as the principal determinant of the observed common phenotype. PMID: 22303795
    6. a critical link between HNF1A-MODY-induced alterations in Bmp-3 expression and insulin gene levels PMID: 21628466
    7. Features supportive of positive selection in the BMP3 gene were found including the presence of an excess of nonsynonymous mutations in modern humans, and a significantly lower genetic diversity that deviates from neutrality PMID: 20532035
    8. Data suggest that promotor region methylation of the BMP3 gene may cause gastric carcinoma in Chinese people. PMID: 20238409
    9. These results demonstrate that BMP-3 stimulates mesenchymal stem cell proliferation via the TGF-beta/activin signaling pathway. PMID: 20143330
    10. The expression signals of BMP3 mRNA in malignant schwannoma were relatively lower than in benign lesions PMID: 11642720
    11. BMP-3 receptor specificity is controlled by the interaction of Lys-30 of BMP-3 with Glu-76 of ActRIIb PMID: 17924656
    12. BMP3 silencing is an early and frequent event in colorectal tumors progressing via the serrated and traditional pathways. PMID: 18311777

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 組織特異性：
    Expressed in adult and fetal cartilage.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1070

    OMIM: 112263

    KEGG: hsa:651

    STRING: 9606.ENSP00000282701

    UniGene: Hs.387411