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  4. Human C-C motif chemokine 16(CCL16) ELISA kit

Human C-C motif chemokine 16(CCL16) ELISA kit

  • 中文名稱：
    人CC趨化因子16(CCL16)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL004779HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人CC趨化因子16(CCL16)酶聯(lián)免疫試劑盒（CSB-EL004779HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL16含量。CCL16，也稱為CC趨化因子4、肝表達(dá)趨化因子（LEC）和Monotactin-1（MTN-1），是CC趨化因子家族的一員，位于人類17號染色體。CCL16通過與細(xì)胞表面趨化因子受體CCR1、CCR2、CCR5和CCR8相互作用，影響細(xì)胞功能，具有趨化單核細(xì)胞和淋巴細(xì)胞的能力，不趨化嗜中性粒細(xì)胞。近期研究發(fā)現(xiàn)，CCL16在腫瘤排斥、巨噬細(xì)胞抗原呈遞和血管內(nèi)皮細(xì)胞血管生成活性中起重要作用，同時增強(qiáng)細(xì)胞毒性T細(xì)胞和樹突狀細(xì)胞淋巴細(xì)胞的抗癌作用。試劑盒檢測范圍為39.06 pg/mL-2500 pg/mL，靈敏度為9.77 pg/mL。在肝臟疾病、腫瘤微環(huán)境調(diào)控及免疫相關(guān)疾病研究中具有重要價值；適用于體外研究，支持科研人員探索CCL16在炎癥性疾病機(jī)制、免疫細(xì)胞趨化行為調(diào)控、肝纖維化或腫瘤免疫微環(huán)境中的表達(dá)變化，為分子機(jī)制研究及生物標(biāo)志物篩選提供可靠工具；滿足多種生物樣本的定量分析需求本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    C-C motif chemokine 16 ELISA Kit; CCL16 ELISA Kit; CCL16_HUMAN ELISA Kit; Chemokine (C-C motif) ligand 16 ELISA Kit; Chemokine CC-4 ELISA Kit; Chemokine LEC ELISA Kit; CKb12 ELISA Kit; HCC-4 ELISA Kit; HCC4 ELISA Kit; IL-10-inducible chemokine ELISA Kit; IL10 inducible chemokine ELISA Kit; IL10 inducible chemokine ELISA Kit; ILINCK ELISA Kit; LCC-1 ELISA Kit; LCC1 ELISA Kit; Liver CC chemokine 1 precursor ELISA Kit; Liver expressed chemokine ELISA Kit; Liver-expressed chemokine ELISA Kit; LMC ELISA Kit; Lymphocyte and monocyte chemoattractant ELISA Kit; Monotactin 1 ELISA Kit; Monotactin-1 ELISA Kit; MTN-1 ELISA Kit; Mtn1 ELISA Kit; NCC-4 ELISA Kit; NCC4 ELISA Kit; New CC chemokine 4 ELISA Kit; SCYA16 ELISA Kit; SCYL4 ELISA Kit; Small inducible cytokine A16 precursor ELISA Kit; Small inducible cytokine A16 precursor ELISA Kit; Small inducible cytokine subfamily A (Cys Cys) member 16 ELISA Kit; Small-inducible cytokine A16 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    39.06 pg/mL-2500 pg/mL
  • 靈敏度：
    9.77 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

    　

    Intra-Assay Precision

    Inter-Assay Precision

    Sample

    1

    2

    3

    1

    2

    3

    n

    20

    20

    20

    20

    20

    20

    Mean(pg/ml)

    312.528

    312.182

    312.923

    313.120

    312.775

    312.676

    SD

    0.038

    0.038

    0.027

    0.042

    0.040

    0.045

    CV(%)

    5.574

    5.580

    3.956

    6.150

    5.863

    6.598

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of human CCL16 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:2

    Average %

    90

    Range %

    80-95

    1:4

    Average %

    97

    Range %

    91-105

    1:8

    Average %

    99

    Range %

    92-110

    1:16

    Average %

    92

    Range %

    86-99

  • 回收率：

    The recovery of human CCL16 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    96

    89-98

    EDTA plasma (n=4)

    94

    91-100

  • 標(biāo)準(zhǔn)曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    pg/ml

    OD1

    OD2

    Average

    Corrected

    2500

    2.795

    2.880

    2.838

    2.680

    1250

    2.147

    2.142

    2.145

    1.987

    625

    1.317

    1.426

    1.372

    1.214

    312.5

    0.647

    0.667

    0.657

    0.499

    156.25

    0.367

    0.325

    0.346

    0.188

    78.13

    0.227

    0.244

    0.236

    0.078

    39.06

    0.174

    0.179

    0.177

    0.019

    0

    0.159

    0.157

    0.158

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
        CCL16（也稱為HCC-4）是一種由多種細(xì)胞產(chǎn)生的蛋白質(zhì)，如巨噬細(xì)胞和淋巴細(xì)胞。它是一種趨化因子，可以吸引單核細(xì)胞、樹突狀細(xì)胞等炎癥相關(guān)細(xì)胞的遷移。研究表明，CCL16參與了許多疾病的發(fā)生和發(fā)展，如腫瘤、類風(fēng)濕性關(guān)節(jié)炎、自身免疫性疾病等。
     
  • 功能：
    Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
  • 基因功能參考文獻(xiàn)：
    1. Overexpression of miR-1247 may alleviate LPS-induced A549 cell injury through targeting CCL16. PMID: 29768218
    2. Single nucleotide polymorphism (SNPs) located in and around the C-C motif chemokine ligand 16 (CCL16) gene are associated with CCL16 protein levels in blood plasma, and rs80329614 is the SNP most strongly associated with CCL16 protein levels in plasma. PMID: 27357396
    3. High umbilical artery CCL16 is prominently detected in preterm preeclamptic pregnancies with severe growth restriction. PMID: 22857868
    4. Data show that CCL-16 gene expression was upregulated by 7.46-fold in IBS patients when compared with controls and suggest a subclinical inflammatory component underlying IBS. PMID: 21951809
    5. Low umbilical cord blood chemokine CCL16 associates with spontaneous preterm birth PMID: 21288736
    6. Recombinant CCL16 significantly enhances the effector and the antigen-presenting function of macrophages and augments T cell lytic activity. PMID: 14525962
    7. An adenoviral vector encoding human CCL16 injected into mice with pre-established mammary carcinoma induces strong antitumor response; when given before surgical excision of primary lesions, the treatment prevents metastatic spread and cures 63% of mice. PMID: 15034014
    8. CCL16 induced efficient migratory responses in human and mouse eosinophils. CCL16 is a novel functional ligand for H4 and may have a role in trafficking of eosinophils. PMID: 15265943
    9. CC chemokine-4 (HCC-4)/CCL16 transduces signals differently from other CCR1-dependent chemokines and may play different roles in the immune response. PMID: 16226254
    10. Elevated concentrations in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia PMID: 19494526

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 組織特異性：
    Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10614

    OMIM: 601394

    KEGG: hsa:6360

    STRING: 9606.ENSP00000293275

    UniGene: Hs.10458