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  4. Human C-C motif chemokine 4(CCL4) ELISA kit

Human C-C motif chemokine 4(CCL4) ELISA kit

  • 中文名稱：
    人CC趨化因子4(CCL4)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL004797HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人CC趨化因子4(CCL4)酶聯(lián)免疫試劑盒（CSB-EL004797HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL4含量。CCL4是一種重要靶點(diǎn)。它屬于趨化因子，在免疫調(diào)節(jié)、炎癥反應(yīng)等生理過程中發(fā)揮關(guān)鍵作用。研究機(jī)制方面，CCL4與其受體結(jié)合，趨化特定免疫細(xì)胞遷移，在感染、自身免疫病等病理進(jìn)程中參與免疫應(yīng)答，是疾病治療和藥物研發(fā)的潛在方向。試劑盒檢測范圍為31.2 pg/ml- 2000 pg/ml，靈敏度為7.8 pg/ml?？蒲泄ぷ髡呖山柚井a(chǎn)品定量分析CCL4在炎癥模型中的表達(dá)動(dòng)態(tài)，探究其在免疫細(xì)胞趨化、病原體感染后免疫應(yīng)答或腫瘤相關(guān)巨噬細(xì)胞活化中的作用機(jī)制，為免疫調(diào)控研究、疾病模型構(gòu)建及藥物干預(yù)效果評估提供可靠工具。本產(chǎn)品僅限科學(xué)研究使用，不適用于醫(yī)療診斷或其他非科研場景。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    MIP 1 beta ELISA Kit; Secreted protein G 26 ELISA Kit; ACT 2 ELISA Kit; ACT-2 ELISA Kit; ACT2 ELISA Kit; AT744.1 ELISA Kit; AT744.2 ELISA Kit; C C motif chemokine 4 ELISA Kit; C C motif chemokine 4 like ELISA Kit; C C motif chemokine ligand 4 like 1 ELISA Kit; C C motif chemokine ligand 4 like 2 ELISA Kit; CC chemokine ligand 4 ELISA Kit; CC chemokine ligand 4L1 ELISA Kit; CC chemokine ligand 4L1d2 ELISA Kit; CC chemokine ligand 4L2 ELISA Kit; CCL4 ELISA Kit; CCL4_HUMAN ELISA Kit; ccl4l 1 ELISA Kit; CCL4L ELISA Kit; CCL4L1 ELISA Kit; Chemokine (C C motif) ligand 4 ELISA Kit; Chemokine (C C motif) ligand 4 like 1 ELISA Kit; Chemokine (C C motif) ligand 4 like 1; telomeric ELISA Kit; Chemokine (C C motif) ligand 4 like 2 ELISA Kit; Chemokine CC Motif Ligand 4 ELISA Kit; G 26 ELISA Kit; G 26 T lymphocyte secreted protein ELISA Kit; G-26 T-lymphocyte-secreted protein ELISA Kit; HC21 ELISA Kit; Immune activation 2 ELISA Kit; LAG 1 ELISA Kit; LAG-1 ELISA Kit; LAG1 ELISA Kit; Lymphocyte activation gene 1 ELISA Kit; Lymphocyte activation gene 1 protein ELISA Kit; Macrophage inflammatory protein 1 beta ELISA Kit; Macrophage inflammatory protein 1-beta ELISA Kit; Macrophage inflammatory protein 1b2 ELISA Kit; MGC104418 ELISA Kit; MGC126025 ELISA Kit; MGC126026 ELISA Kit; MIP-1-beta ELISA Kit; MIP-1-beta(1-69) ELISA Kit; MIP-1-beta(3-69) ELISA Kit; MIP1 beta ELISA Kit; MIP1B ELISA Kit; MIP1B1 ELISA Kit; Monocyte adherence induced protein 5 alpha ELISA Kit; PAT 744 ELISA Kit; Protein H400 ELISA Kit; SCYA2 ELISA Kit; SCYA4 ELISA Kit; SCYA4L ELISA Kit; SCYA4L1 ELISA Kit; SCYA4L2 ELISA Kit; SCYQ4L2 ELISA Kit; Secreted protein G 26 ELISA Kit; Secreted protein G26 ELISA Kit; SIS gamma ELISA Kit; SIS-gamma ELISA Kit; Small inducible cytokine A4 (homologous to mouse Mip 1b) ELISA Kit; Small inducible cytokine A4 ELISA Kit; small inducible cytokine A4-like ELISA Kit; Small-inducible cytokine A4 ELISA Kit; T cell activation protein 2 ELISA Kit; T-cell activation protein 2 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    31.2 pg/ml - 2000 pg/ml
  • 靈敏度：
    7.8 pg/ml
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
  • 基因功能參考文獻(xiàn)：
    1. identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3, CCL4/CCL4L1/CCL4L2, CD160, IFNG, NR4A3 and XCL1/XCL2) were analyzed in 127 kidney biopsies PMID: 25449536
    2. PCR results show that lower copy numbers of CCL4L1 are observed in the Caucasian population nd higher copy numbers are observed in the Black population of South Africa. PMID: 24727646
    3. CCL4L1 allele frequency is higher in severe psoriasis, whereas CCL4L2 is more frequent in patients with a milder disease. PMID: 21614014
    4. multiple copies of CCL3L1 and CCL4L1 present in a single diploid genome are the result of segmental duplication at chromosome 17q12 PMID: 15028295
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10630

    OMIM: 182284

    KEGG: hsa:388372

    STRING: 9606.ENSP00000250151

    UniGene: Hs.449862