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  4. Human C-X-C motif chemokine 3(CXCL3) ELISA kit

Human C-X-C motif chemokine 3(CXCL3) ELISA kit

  • 中文名稱：
    人C-X-C趨化因子3(CXCL3)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL006249HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人C-X-C趨化因子3(CXCL3)酶聯(lián)免疫試劑盒（CSB-EL006249HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CXCL3含量。CXCL3 作為一個靶點，在生物學領域有重要意義。它參與多種生理和病理過程。研究發(fā)現(xiàn)，CXCL3 可能與炎癥反應、腫瘤發(fā)展等機制相關。針對它的研究主要聚焦于其信號傳導通路，以探尋調控其活性的方法，從而為相關疾病治療提供新思路。試劑盒檢測范圍為9.37 pg/mL-600 pg/mL，該產(chǎn)品適用于體外檢測人或相關模式生物（經(jīng)交叉反應驗證）來源樣本中CXCL3的表達動態(tài)，可為炎癥性疾病機制研究、免疫調控通路探索或藥物開發(fā)中的生物標志物分析提供靈敏、穩(wěn)定的檢測工具，尤其適合基礎科研中涉及趨化因子網(wǎng)絡調控、免疫微環(huán)境分析或病理模型驗證等研究方向。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    C-X-C motif chemokine 3 ELISA Kit; C-X-C motif chemokine ligand 3 ELISA Kit; Chemokine (C X C motif) ligand 3 ELISA Kit; Chemokine (CXC motif) ligand 3 ELISA Kit; Cinc 2 ELISA Kit; CINC 2b ELISA Kit; Cinc2 ELISA Kit; CINC2b ELISA Kit; CXCL 3 ELISA Kit; Cxcl3 ELISA Kit; CXCL3_HUMAN ELISA Kit; Cytokine induced neutrophil chemoattractant 2 ELISA Kit; Dcip1 ELISA Kit; Dendritic cell inflammatory protein 1 ELISA Kit; Gm1960 ELISA Kit; GRO protein gamma ELISA Kit; GRO-gamma ELISA Kit; GRO-gamma(1-73) ELISA Kit; GRO-gamma(5-73) ELISA Kit; GRO3 ELISA Kit; GRO3 oncogene ELISA Kit; GROG ELISA Kit; Growth regulated protein gamma ELISA Kit; Growth-regulated protein gamma ELISA Kit; Macrophage inflammatory protein 2 beta precursor ELISA Kit; Macrophage inflammatory protein 2-beta ELISA Kit; Melanoma growth stimulatory activity gamma ELISA Kit; Member 3 ELISA Kit; MGSA gamma ELISA Kit; MIP 2b ELISA Kit; MIP2-beta ELISA Kit; MIP2B ELISA Kit; SCYB3 ELISA Kit; Small inducible cytokine subfamily B ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    9.37 pg/mL-600 pg/mL
  • 靈敏度：
    2.34 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human CXCL3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %90
    Range %87-93
    1:2Average %100
    Range %97-103
    1:4Average %95
    Range %92-97
    1:8Average %99
    Range %95-102
  • 回收率：
    The recovery of human CXCL3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9491-97
    EDTA plasma (n=4)9793-99
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    6002.943 2.888 2.916 2.764
    3002.188 2.299 2.244 2.092
    1501.458 1.392 1.425 1.273
    750.778 0.790 0.784 0.632
    37.50.392 0.382 0.387 0.235
    18.750.288 0.269 0.279 0.127
    9.370.240 0.234 0.237 0.085
    00.153 0.151 0.152 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
  • 基因功能參考文獻：
    1. CXCL3 exerts its carcinogenic potential by directly and/or indirectly regulating the downstream signaling pathways and the expression of transcription factors in PCa. PMID: 29524043
    2. Exogenous CXCL3 induced Erk1/2 and ETS1 phosphorylation and promoted CD133 expression. PMID: 27255419
    3. Our findings suggest that CXCL3 and its receptor CXCR2 are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis. PMID: 26837773
    4. results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy PMID: 24605943
    5. CXCL3 displays antimicrobial activity against E. coli and S. aureus. PMID: 12949249
    6. secreted growth-regulated oncogene chemokines, specifically GRO-gamma, in human Mesenchymal stromal cell-conditioned media have an effect on the differentiation and the function of human monocyte-derived dendritic cells. PMID: 23589610
    7. Data show that mesenchymal stem cells (MSCs) directly regulate T cell proliferation by induction of CXCL3 chemokine and its receptor, CXCR2 on the surface in T cells. PMID: 23023221
    8. demonstrates, for the first time, that BIRC3 (anti-apoptotic protein), COL3A1 (matrix protein synthesis), and CXCL3 (chemokine) were up-regulated in the thrombin-stimulated human umbilical vein endothelial cells PMID: 16356540
    9. GRO-gamma is a promising candidate for Th2-associated glomerular permeability factor in minimal change disease. PMID: 17389786
    10. Inhibition of ERK phosphorylation decreased expression of GRO3. PMID: 17466952
    11. Report gonadotropin-releasing hormone-regulated CXCL3 expression in human placentation. PMID: 19369450
    12. propose that chemokines belonging to the CXC family could play an important role in the etiology of tendon xanthoma (TX), with CXCL3 being a possible biological marker of onset and development of TX PMID: 19448742
    13. overexpression of CXCL13 in the intestine during inflammatory conditions favors mobilization of B cells and of LTi and NK cells with immunomodulatory and reparative functions. PMID: 19741597

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4604

    OMIM: 139111

    KEGG: hsa:2921

    STRING: 9606.ENSP00000296026

    UniGene: Hs.89690