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  4. Human C4b-binding protein beta chain(C4BPB) ELISA kit

Human C4b-binding protein beta chain(C4BPB) ELISA kit

  • 中文名稱：
    人C4b結(jié)合蛋白β鏈(C4BPB)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL003954HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人C4b結(jié)合蛋白β鏈(C4BPB)酶聯(lián)免疫試劑盒（CSB-EL003954HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的C4BPB含量。人C4b結(jié)合蛋白β鏈（C4BPB）是補(bǔ)體系統(tǒng)中的重要調(diào)節(jié)因子，由β鏈和α鏈組成，主要功能是結(jié)合C3b/C4b，抑制補(bǔ)體系統(tǒng)的過度激活，從而保護(hù)機(jī)體免受自身免疫損傷。研究機(jī)制涉及C4BPB與C3b/C4b的相互作用及其在補(bǔ)體激活途徑中的調(diào)節(jié)作用。試劑盒檢測(cè)范圍為3.12 ng/mL-200 ng/mL，適用于基礎(chǔ)科研中對(duì)補(bǔ)體系統(tǒng)調(diào)控機(jī)制的探索。廣泛應(yīng)用于炎癥性疾病、自身免疫病等補(bǔ)體相關(guān)機(jī)制研究，支持細(xì)胞模型中蛋白分泌水平檢測(cè)或動(dòng)物組織樣本分析，為免疫調(diào)控研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    C4b binding protein beta chain ELISA Kit; C4b-binding protein beta chain ELISA Kit; C4BP ELISA Kit; C4BPB ELISA Kit; C4BPB_HUMAN ELISA Kit; Complement component 4 binding protein beta ELISA Kit; Complement component 4 binding protein beta chain ELISA Kit; Complement component 4-binding protein beta ELISA Kit; OTTHUMP00000034288 ELISA Kit; OTTHUMP00000034289 ELISA Kit; OTTHUMP00000034375 ELISA Kit; OTTHUMP0000003474 ELISA Kit; Proline rich protein ELISA Kit; PRP ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測(cè)范圍：
    3.12 ng/mL-200 ng/mL
  • 靈敏度：
    0.78 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human C4BPB in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1000Average %96
    Range %91-108
    1:2000Average %92
    Range %87-99
    1:4000Average %94
    Range %89-98
    1:8000Average %97
    Range %91-112
  • 回收率：
    The recovery of human C4BPB spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9690-105
    EDTA plasma (n=4)9589-101
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    2002.905 2.875 2.890 2.755
    1002.489 2.473 2.481 2.346
    501.734 1.750 1.742 1.607
    250.948 0.957 0.953 0.818
    12.50.512 0.506 0.509 0.374
    6.250.464 0.471 0.468 0.333
    3.1250.230 0.234 0.232 0.097
    00.133 0.136 0.135
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
  • 基因功能參考文獻(xiàn)：
    1. SAA, PROZ, and C4BPB may serve as new potential biomarkers for TB PMID: 28278182
    2. Binding of complement inhibitor C4b-binding protein to a highly virulent Streptococcus pyogenes M1 strain is mediated by protein H and enhances adhesion to and invasion of endothelial cells. PMID: 24064215
    3. crystallographic data on the structure of CD11c/CD18 and prediction of the secondary structure of the C4BP oligomerization domain, we show that epitopes bound by KIM185 in these proteins are unlikely to share any major structural similarity. PMID: 21856004
    4. C4BP alpha7beta0 subunit [C4BP alpha7beta0 isoform lacking the beta-chain] induces a semimature, tolerogenic state on human monocyte-derived dendritic cells activated by a proinflammatory stimulus. PMID: 23390292
    5. Since FI requires cofactors for its activity we also investigated the binding of purified cofactors C4BP and FH and found acquisition of both proteins, which retained their activity in FI mediated degradation of C3b and C4b. PMID: 22514678
    6. Results demonstrate that successful secretion of complement regulatory protein C4b-binding protein beta-chains depends on intracellular complex formation with vitamin K-dependent protein S, but not on the alpha-chains. PMID: 20693287
    7. Localized via protein S to the surface of apoptotic cells, C4BP is able to interact with complement protein C4b, thus retaining its physiological role in regulation of complement on the apoptotic cell surface. PMID: 12193728
    8. C4BP is composed of seven alpha-chains and a unique beta-chain, each chain comprising repeating complement control protein (CCP) modules, the results suggest that the role of CCP2 in protein S binding is to orient and stabilize CCP1 PMID: 12492479
    9. C4b-binding protein binds to necrotic cells and DNA, limiting DNA release and inhibiting complement activation. PMID: 15967823
    10. analysis of structural basis for C4b-binding protein interaction with streptococcal M protein PMID: 16330538
    11. review of multiple functional roles of the complex of protein S and cd4-binding protein beta chain, such as binding to apoptotoic cells, phagocytosis PMID: 17597997
    12. C4BP levels are increased in patients suffering from primary Sjogren's syndrome PMID: 19284503

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  • 亞細(xì)胞定位：
    Secreted.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1328

    OMIM: 120831

    KEGG: hsa:725

    STRING: 9606.ENSP00000243611

    UniGene: Hs.99886