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  4. Human CAMPATH-1 antigen(CD52) ELISA kit

Human CAMPATH-1 antigen(CD52) ELISA kit

  • 中文名稱：
    人CAMPATH-1抗原(CD52)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL004943HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人CAMPATH-1抗原(CD52)酶聯(lián)免疫試劑盒（CSB-EL004943HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的CD52含量。CD52是位于淋巴細胞表面的糖蛋白。其作為靶點，在免疫相關疾病治療研究中受關注。通過開發(fā)針對CD52的藥物，與該靶點結合，清除表達CD52的淋巴細胞，以調節(jié)機體免疫反應，用于如多發(fā)性硬化癥等疾病治療。試劑盒檢測范圍為78 ng/mL-5000 ng/mL，本試劑盒適用于科研場景中CD52蛋白表達的定量分析，如免疫細胞功能研究、疾病模型中的免疫機制探索或抗體藥物開發(fā)中靶標水平的監(jiān)測。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Cambridge pathology 1 antigen ELISA Kit; CAMPATH 1 ELISA Kit; CAMPATH 1 antigen ELISA Kit; CAMPATH-1 antigen ELISA Kit; CD 52 ELISA Kit; CD52 ELISA Kit; CD52 antigen ELISA Kit; CD52 molecule ELISA Kit; CD52_HUMAN ELISA Kit; CDw52 ELISA Kit; CDW52 antigen ELISA Kit; Epididymal secretory protein E5 ELISA Kit; Epididymis secretory sperm binding protein Li 171mP ELISA Kit; HE 5 ELISA Kit; He5 ELISA Kit; Human epididymis-specific protein 5 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    78 ng/mL-5000 ng/mL
  • 靈敏度：
    19.5 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human CD52 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %85
    Range %80-90
    1:2Average %98
    Range %91-105
    1:4Average %96
    Range %92-100
    1:8Average %96
    Range %89-102
  • 回收率：
    The recovery of human CD52 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9080-100
    EDTA plasma (n=4)9891-110
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    50001.975 1.952 1.964 1.870
    25001.612 1.586 1.599 1.505
    12501.272 1.171 1.222 1.128
    6250.984 0.932 0.958 0.864
    3120.665 0.629 0.647 0.553
    1560.398 0.368 0.383 0.289
    780.193 0.201 0.197 0.103
    00.097 0.091 0.094 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
  • 基因功能參考文獻：
    1. soluble CD52 exerts a concerted immunosuppressive effect by first sequestering HMGB1 to nullify its proinflammatory Box B, followed by binding to the inhibitory Siglec-10 receptor, triggering recruitment of SHP1 to the intracellular immunoreceptor tyrosine-based inhibitory motif of Siglec-10 and its interaction with the TCR. PMID: 29997173
    2. CD52 is a novel prognostic NSC marker and a potential NSC target in a subset of patients with MDS and AML, which may have clinical implications and may explain clinical effects produced by alemtuzumab in these patients. PMID: 24799522
    3. carbohydrate moiety of sperm protein interferes with the complement system via binding to C1q PMID: 22386526
    4. CT60 single-nucleotide polymorphism of CTLA4 is a surrogate marker for donor lymphocyte infusion outcome after allogeneic cell transplantation for acute leukemia PMID: 21552305
    5. Clonal large granular lymphocytes exhibited decreased CD52 expression post-therapy in patients refractory to treatment. PMID: 19794084
    6. Our bioinformatics findings suggest that CD52 polymorphism may affect the efficiency of GPI anchor formation and thus may indirectly alter the response to anti-CD52 agents like alemtuzumabin renal transplantation. PMID: 20349607
    7. Review article on CD52 structure and function. PMID: 11860230
    8. HE5(CD52) mRNA and protein, expressed in epithelial cells of the distal epididymis, were not affected by the obstruction of the vas deferens. PMID: 14662784
    9. The relationship between this differential insertion and differences in glycosylation of rat and human CD52 is discussed. PMID: 16266689
    10. CD52 is widely expressed on human mast cells (MCs) and Waldenstrom's Macroglobulinemia bone marrow lymphoplasmacytic cells and provide the preclinical rationale for the use of alemtuzumab in the treatment of WM and possibly other MC-related disorders. PMID: 16796779
    11. In this study, we identified the antigen of 4C8 mAb as CD52. CD52 is a costimulatory molecule for induction of CD4-positive T cells. PMID: 16797237
    12. In contrast with CLL, the variable expression of CD52 among other hematologic malignancies suggests that target validation on a case-by-case basis will likely be necessary to guide the rational analysis of CAMPATH therapy. PMID: 17145843
    13. Our data demonstrate differences in the intensity of the CD52 antigen expression between B-lymphocytes and tumor lymphocytes of B-CLL patients, and between B-CLL and SLL tumor cells. CD52 antigen is expressed at low level on CD34(+) cells. PMID: 17428002
    14. The semenogelin-CD52 soluble form is a direct consequence of the liquefaction process in human semen. PMID: 17624925
    15. We first showed the expression of CD52 in human cumulus cells. CD52 has some functional roles around fertilization in females as well as in males. PMID: 18647288
    16. A review on CD52 expression and function PMID: 11257744

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 數據庫鏈接：

    HGNC: 1804

    OMIM: 114280

    KEGG: hsa:1043

    STRING: 9606.ENSP00000363330

    UniGene: Hs.276770