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  4. Human CD109 antigen(CD109) ELISA kit

Human CD109 antigen(CD109) ELISA kit

  • 中文名稱：
    人CD109抗原(CD109)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL004878HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人CD109抗原(CD109)酶聯(lián)免疫試劑盒（CSB-EL004878HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的CD109含量。CD109是一種細胞表面糖蛋白，在多種組織細胞中表達。它與腫瘤發(fā)生、免疫調(diào)節(jié)等密切相關(guān)。研究機制方面，其可能通過參與信號傳導通路影響細胞增殖、遷移等。目前圍繞CD109作為靶點的藥物研發(fā)等相關(guān)研究正在持續(xù)推進。試劑盒檢測范圍為94 pg/mL-6000 pg/mL，適用于基礎(chǔ)科研領(lǐng)域，如探究CD109在腫瘤發(fā)生、免疫調(diào)控或組織修復中的分子機制，支持通過多種生物樣本分析其在疾病模型或細胞實驗中的動態(tài)表達變化，為體外實驗提供高靈敏度的定量檢測方案，本產(chǎn)品僅用于科學研究用途。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    150 KDa TGF beta 1 binding protein ELISA Kit; 150 KDa TGF-beta-1-binding protein ELISA Kit; 7D1 ELISA Kit; 8A3 ELISA Kit; Activated T cell marker CD109 ELISA Kit; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7 ELISA Kit; CD 109 ELISA Kit; CD109 ELISA Kit; CD109 antigen ELISA Kit; CD109_HUMAN ELISA Kit; CPAMD7 ELISA Kit; DKFZp762L1111 ELISA Kit; E123 ELISA Kit; FLJ38569 ELISA Kit; FLJ41966 ELISA Kit; Gov system alloantigens on platelets ELISA Kit; p180 ELISA Kit; Platelet specific Gov antigen ELISA Kit; Platelet-specific Gov antigen ELISA Kit; r150 ELISA Kit; RP11 525G3.1 ELISA Kit
  • 縮寫：
    CD109
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    94 pg/mL-6000 pg/mL
  • 靈敏度：
    23.4 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human CD109 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %89
    Range %85-92
    1:2Average %84
    Range %80-88
    1:4Average %96
    Range %93-99
    1:8Average %102
    Range %98-106
  • 回收率：
    The recovery of human CD109 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9490-98
    EDTA plasma (n=4)8581-89
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    60002.008 2.157 2.083 1.928
    30001.604 1.630 1.617 1.462
    15001.191 1.175 1.183 1.028
    7500.784 0.772 0.778 0.623
    3750.472 0.498 0.485 0.330
    187.50.304 0.315 0.310 0.155
    940.212 0.216 0.214 0.059
    00.152 0.157 0.155
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Modulates negatively TGFB1 signaling in keratinocytes.
  • 基因功能參考文獻：
    1. GRP78 binds to and acts in concert with a glycosylphosphatidylinositol-anchored protein, CD109, in blocking TGF-beta signaling by promoting the routing of the TGF-beta receptor to the caveolae, thereby disrupting its binding to and activation of Smad2. PMID: 29654145
    2. CD109 knockdown upregulated IL-8 expression through activation of TGF-beta/Akt/NF-kappaB pathway in human umbilical vein endothelial cells PMID: 27121053
    3. High expression of CD109 in brain tumor stem cells is involved in glioma progression. PMID: 28888050
    4. The CD109 protein was up-regulated in hepatocellular carcinoma tissue compared with adjacent noncancerous tissue. CD109 shRNA knockdown delayed the G1-S phase transition, abrogated cell proliferation, and increased cell apoptosis. Furthermore, CD109 impaired TGF-beta/Smad signaling through control of p-smad2. PMID: 27074923
    5. CD109 is a putative biomarker for identifying a high-risk group among DLBCL patients. PMID: 28032275
    6. Expression levels of CD109 was reduced significantly in psoriasis. Lower expression of CD109 and TGF-beta RI was highly correlated with higher expression of Smad7 and Ki67, suggesting that CD109 may induce the pathogenesis of psoriasis through Smad7-mediated degradation of TGF-beta RI. PMID: 26838754
    7. sCD109 can bind TGF-beta, inhibit TGF-beta binding to its receptors and decrease TGF-beta signalling and TGF-beta-induced cellular responses. PMID: 26621871
    8. These findings indicate that CD109 is an exosomal protein and that the C-terminal region of CD109 is required for its presence in the exosome. PMID: 26707640
    9. CD109 may be a potential pathology marker for gallbladder squamous cell/adenosquamous carcinomas. PMID: 26249215
    10. CD109 is specifically expressed in endothelial cells of cutaneous cavernous haemangioma. PMID: 25388101
    11. expression increased in cutaneous squamous cell carcinoma PMID: 25271095
    12. The results suggest that circulating endothelial cells express CD109 and represent a rare population of circulating tumor endothelial cells, that play a potentially useful prognostic role in patients with glioblastoma. PMID: 25506915
    13. CD109 overexpression was significantly associated with surgical stage, distant metastasis, and poor prognosis in myxofibrosarcoma. PMID: 26031650
    14. Three glioblastoma cell lines, SK-MG-1, U251MG and MG178, were tested and CD109 overexpression attenuated TGF-beta1 signaling and enhanced EGF signaling in SK-MG-1, but not in U251MG or MG178. PMID: 25724945
    15. CD109 is highly expressed in TNBC and is a potential biomarker for the initiation, progression, and differentiation of breast cancer tumors. PMID: 25149155
    16. CD109 plays a critical role in non-small-cell lung cancer (NSCLC) progression, and is overexpressed in advanced NSCLC PMID: 24667143
    17. High expression of CD109 antigen regulates the phenotype of cancer stem-like cells/cancer-initiating cells in a novel epithelioid sarcoma cell line ESX and is related to poor prognosis of soft tissue sarcoma. PMID: 24376795
    18. Hematopoietic cell marker CD109 is expressed in hepatic progenitor cells. PMID: 24396288
    19. expression of CD109 (human platelet antigen 15) mRNA is different in various human cell types PMID: 23509816
    20. The upregulation of CD109 protein in SSc may represent an adaptation or consequence of aberrant TGF-beta signaling in systemic sclerosis PMID: 22694813
    21. CD109 is an important regulator of SMAD7/Smurf2-mediated degradation of TGFBR1. PMID: 21898545
    22. CD109 release from the cell surface in human keratinocytes regulates TGF-beta receptor expression, TGF-beta signalling and STAT3 activation. PMID: 21539622
    23. CD109 regulates TGF-beta receptor endocytosis and degradation to inhibit TGF-beta signaling. PMID: 21295082
    24. Report PRSS3/mesotrypsin upregulation in breast cancer cells and identify CD109 as the functional proteolytic target of mesotrypsin. PMID: 20035377
    25. These findings suggest that CD109 is involved in bladder tumorigenesis and is a potential target for cancer immunotherapy. PMID: 20946523
    26. Processing of CD109 into 180 kDa and 25 kDa proteins by furin, followed by complex formation with the type I TGF-beta receptor is required for the regulation of TGF-beta signaling in cancer cells and keratinocytes. PMID: 20101215
    27. Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins. cDNA sequence determination and protein structure analysis given. PMID: 11861284
    28. A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens. PMID: 11861285
    29. Findings suggest that CD109 may become a molecular target for the development of new therapeutics for squamous cell carcinoma of various tissue origins. PMID: 15826242
    30. CD109 plays a unique role in the regulation of isoform-specific TGF-beta signaling in keratinocytes. PMID: 16754747
    31. Findings indicate that CD109 is a useful marker for the diagnosis of invasive breast and prostate carcinomas. PMID: 17493171
    32. the novel gene HEPT3 may function through its noncoding RNA and its overexpression may play a role in hepatocarcinogenesis [HEPT3] PMID: 17611685
    33. CD109 expression may play a role in the development of lung squamous cell carcinoma. PMID: 17922683
    34. Up-regulation of CD109 expression is associated with carcinogensis of the squamous epithelium of the oral cavity. PMID: 19016750
    35. Found with a mutation in 7% of colon cancers studied. PMID: 16959974

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Protease inhibitor I39 (alpha-2-macroglobulin) family
  • 組織特異性：
    Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and act
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21685

    OMIM: 608859

    KEGG: hsa:135228

    STRING: 9606.ENSP00000287097

    UniGene: Hs.399891