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  4. Human Cardiotrophin-like cytokine factor 1(CLCF1) ELISA kit

Human Cardiotrophin-like cytokine factor 1(CLCF1) ELISA kit

  • 中文名稱：
    人心臟營養(yǎng)素樣細(xì)胞因子1(CLCF1)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL005479HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人心臟營養(yǎng)素樣細(xì)胞因子1(CLCF1)酶聯(lián)免疫試劑盒（CSB-EL005479HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的CLCF1含量。CLCF1即睫狀神經(jīng)營養(yǎng)因子樣細(xì)胞因子1，在人體生理和病理過程中發(fā)揮一定作用。研究聚焦于其參與的細(xì)胞信號傳導(dǎo)通路，如與受體結(jié)合介導(dǎo)的信號傳遞，探尋其在神經(jīng)發(fā)育、免疫調(diào)節(jié)及疾病發(fā)生發(fā)展等方面機(jī)制，以助力相關(guān)疾病治療靶點(diǎn)開發(fā)。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，該產(chǎn)品可滿足體外實(shí)驗(yàn)中對CLCF1蛋白表達(dá)量的精準(zhǔn)檢測需求，支持心血管疾病機(jī)制研究、炎癥信號通路分析以及藥物開發(fā)中的生物標(biāo)志物探索等科研場景，尤其適用于細(xì)胞模型、動物實(shí)驗(yàn)或臨床前研究中相關(guān)樣本的定量檢測。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    B cell stimulating factor 3 ELISA Kit; B-cell-stimulating factor 3 ELISA Kit; BSF 3 ELISA Kit; BSF-3 ELISA Kit; BSF3 ELISA Kit; Cardiotrophin like cytokine ELISA Kit; Cardiotrophin like cytokine factor 1 ELISA Kit; Cardiotrophin-like cytokine factor 1 ELISA Kit; CISS 2 ELISA Kit; CISS2 ELISA Kit; CLC ELISA Kit; CLCF 1 ELISA Kit; Clcf1 ELISA Kit; CLCF1_HUMAN ELISA Kit; Cold induced sweating syndrome 2 ELISA Kit; CRLF 1 associated cytokine like factor 1 ELISA Kit; CRLF1 associated cytokine like factor 1 ELISA Kit; Neurotrophin 1 ELISA Kit; Neurotrophin 1/B cell stimulating factor 3 ELISA Kit; Neurotrophin1 ELISA Kit; NNT 1 ELISA Kit; NNT-1 ELISA Kit; Novel neurotrophin 1 ELISA Kit; Novel neurotrophin-1 ELISA Kit; NR 6 ELISA Kit; NR6 ELISA Kit
  • 縮寫：
    CLCF1
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.
  • 基因功能參考文獻(xiàn)：
    1. CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover. PMID: 26858303
    2. Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders. PMID: 26198769
    3. albuminuria in focal segmental glomerulosclerosis is related to qualitative or quantitative changes in the CLCF1-CRLF1 complex. PMID: 25843671
    4. activation of the Jak-STAT cascade is essential for corticotroph NNT-1/BSF-3 signaling. PMID: 12639901
    5. Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha. PMID: 16782820
    6. Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain PMID: 18728012

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  • 相關(guān)疾?。?/div>
    Cold-induced sweating syndrome 2 (CISS2)
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    IL-6 superfamily
  • 組織特異性：
    Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17412

    OMIM: 607672

    KEGG: hsa:23529

    STRING: 9606.ENSP00000309338

    UniGene: Hs.502977