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  4. Human Coagulation factor XIII B chain(F13B) ELISA kit

Human Coagulation factor XIII B chain(F13B) ELISA kit

  • 中文名稱：
    人凝血因子XIIIB鏈(F13B)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL007922HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人凝血因子XIIIB鏈(F13B)酶聯(lián)免疫試劑盒（CSB-EL007922HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、尿液、組織勻漿樣本中的F13B含量。F13B是凝血因子XIII的B亞基，參與凝血級聯(lián)反應(yīng)的最后環(huán)節(jié)，與A亞基共同組成異四聚體。F13B缺乏催化活性，但能穩(wěn)定A亞基并調(diào)節(jié)凝血酶激活轉(zhuǎn)谷氨酰胺酶，從而穩(wěn)定纖維蛋白凝塊。F13B基因突變可導(dǎo)致遺傳性FXIII缺陷癥，表現(xiàn)為終身出血傾向、傷口愈合不良等。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，本試劑盒適用于生命科學(xué)領(lǐng)域研究，可用于探究F13B在血栓形成、遺傳性凝血缺陷或組織修復(fù)等生理病理過程中的動態(tài)變化，為心血管疾病模型構(gòu)建、藥物干預(yù)效果評估及分子機制研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    F13B ELISA Kit; Coagulation factor XIII B chain ELISA Kit; Fibrin-stabilizing factor B subunit ELISA Kit; Protein-glutamine gamma-glutamyltransferase B chain ELISA Kit; Transglutaminase B chain ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, urine, tissue homogenates
  • 檢測范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Blood Coagulation
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human F13B in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:100 Average % 85
    Range % 81-89
    1:200 Average % 93
    Range % 90-96
    1:400 Average % 104
    Range % 100-108
    1:800 Average % 99
    Range % 95-103
  • 回收率：
    The recovery of human F13B spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 107 103-110
    EDTA plasma (n=4) 89 86-91
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    20 2.734 2.654 2.694 2.617
    10 2.122 2.205 2.164 2.087
    5 1.497 1.487 1.492 1.415
    2.5 0.875 0.898 0.887 0.810
    1.25 0.533 0.568 0.551 0.474
    0.625 0.331 0.352 0.342 0.265
    0.312 0.206 0.198 0.202 0.125
    0 0.079 0.075 0.077 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.
  • 基因功能參考文獻(xiàn)：
    1. In VTE patients the changes of FXIII level and their effect on the risk of VTE show considerable sex-specific differences. Intron K polymorphism results in decreased FXIII levels, but does not influence the risk of VTE. PMID: 28865246
    2. The results suggest that plasma FXIII levels are subjected to multifactorial regulation with age, fibrinogen level and FXIII-B intron K polymorphism being the major determinants. Their effect on FXIII levels might influence the risk of thrombotic diseases. PMID: 27821352
    3. Genetic markers associated with low FXIIIB levels increase risk of ischemic stroke cardioembolic subtype. PMID: 26159793
    4. The FXIII-B intron K nt29756 G allele was associated with significant protection against CAS and MI in patients with a fibrinogen level in the upper tertile. PMID: 25569091
    5. Changes in plasma levels of FXIIIB are associated with cognitive decline in the elderly. PMID: 26088309
    6. Here, we update the knowledge about the pathophysiology of factor XIII deficiency and its therapeutic options. [review] PMID: 24503678
    7. Case Report: congenital FXIII-B deficiency in which alloantibodies developed to exogenous FXIII-B. PMID: 23407795
    8. FXIIIb subunit is found to be within normal range in eight Tunisian famillies with congenital factor XIII deficiency caused by two mutations, while expression of the FXIIIA subunit gene is decreased or undetectable. PMID: 19937244
    9. Develop ELISA/chemoluminescence assay demonstrating that FXIII-A and FXIII-B are low concentration components of tear proteome. PMID: 20079358
    10. role of FXIIIB in modifying catalytic activity of FXIIIA2 during factor XIII mediated crosslinking of fibrinogen PMID: 11816711
    11. F13 B subunit antigen may have a role in susceptibility to stroke based on this study of family members of patients in South Asia PMID: 15634282
    12. Genetic variants of factor XIIIb were evaluated on the effects of survival in myocardial infarction. PMID: 17515963
    13. at least 3 out of the 10 Sushi domains of FXIII-B have the distinct function of forming a homodimer and a heterotetramer, which should be ascribed to the differences in their amino acid sequences PMID: 18652485
    14. A specific colorimetric assay for measuring FXIIIB activity is reported. PMID: 19646949

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  • 相關(guān)疾?。?/div>
    Factor XIII subunit B deficiency (FA13BD)
  • 亞細(xì)胞定位：
    Secreted.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3534

    OMIM: 134580

    KEGG: hsa:2165

    STRING: 9606.ENSP00000356382

    UniGene: Hs.435782