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  4. Human Collectin-12(COLEC12) ELISA kit

Human Collectin-12(COLEC12) ELISA kit

  • 中文名稱：
    人膠原凝集素-12(COLEC12)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL005762HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人膠原凝集素-12(COLEC12)酶聯(lián)免疫試劑盒（CSB-EL005762HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的COLEC12含量。COLEC12是一種多功能清道夫受體，具有低密度脂蛋白顆粒結(jié)合活性、模式識(shí)別受體活性和清道夫受體活性，在免疫應(yīng)答中發(fā)揮作用，位于含有膠原的細(xì)胞外基質(zhì)中，參與多種生物學(xué)過程。研究機(jī)制涉及其在宿主防御、細(xì)胞粘附和信號(hào)傳導(dǎo)中的作用。試劑盒檢測(cè)范圍為0.312 ng/mL-20 ng/mL，科研領(lǐng)域可用于探究COLEC12在感染性疾病、免疫調(diào)控機(jī)制、慢性炎癥或腫瘤微環(huán)境中的表達(dá)特征，例如研究病原體 - 宿主互作模型中的分子響應(yīng)、評(píng)估組織損傷修復(fù)過程中COLEC12的動(dòng)態(tài)變化，或解析特定疾病模型中該蛋白的表達(dá)調(diào)控網(wǎng)絡(luò)，為相關(guān)基礎(chǔ)研究提供可靠的檢測(cè)工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    CL P1 ELISA Kit; CL-P1 ELISA Kit; CLP1 ELISA Kit; COL12_HUMAN ELISA Kit; COLEC 12 ELISA Kit; colec12 ELISA Kit; Collectin placenta 1 ELISA Kit; Collectin placenta protein 1 ELISA Kit; Collectin sub family member 12 ELISA Kit; Collectin-12 ELISA Kit; hCL P1 ELISA Kit; hCL-P1 ELISA Kit; NSR2 ELISA Kit; Nurse cell scavenger receptor 2 ELISA Kit; SCARA4 ELISA Kit; Scavenger receptor class A member 4 ELISA Kit; Scavenger receptor with C type lectin ELISA Kit; Scavenger receptor with C-type lectin ELISA Kit; SRCL ELISA Kit
  • 縮寫：
    COLEC12
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測(cè)范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human COLEC12 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 84
    Range % 80-88
    1:2 Average % 85
    Range % 82-89
    1:4 Average % 91
    Range % 86-95
    1:8 Average % 104
    Range % 101-107
  • 回收率：
    The recovery of human COLEC12 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 89 85-93
    EDTA plasma (n=4) 90 85-95
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    20 2.541 2.698 2.620 2.498
    10 2.039 2.000 2.020 1.898
    5 1.307 1.368 1.338 1.216
    2.5 0.717 0.738 0.728 0.606
    1.25 0.402 0.398 0.400 0.278
    0.625 0.281 0.278 0.280 0.158
    0.312 0.183 0.179 0.181 0.059
    0 0.123 0.120 0.122 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.
  • 基因功能參考文獻(xiàn)：
    1. CL-P1 is a novel receptor involved in myelin uptake by phagocytes and likely plays a role in multiple sclerosis lesion development. PMID: 28317919
    2. rs17684886 (ZNRF1) and rs599019 (COLEC12) are associated with diabetic retinopathy and rs6427247 (SCYL1BP1) and rs899036 (API5) are associated with severe diabetic retinopathy in Chinese patients with type 2 diabetes PMID: 25819896
    3. The common presence of Lewis(x) groups in granule protein glycans can thus target granule proteins for clearance by SRCL. PMID: 21561871
    4. The Le(x) residues of both, CEACAM1 and CEA, interact with the human Le(x)-binding glycan receptors DC-SIGN and SRCL. PMID: 20034698
    5. haplotype structure of the CL-P1 gene obtained from six single-nucleotide polymorphisms that were genotyped with 108 alleles in Japanese subjects PMID: 12601552
    6. SRCL is expressed in some but not all nurse-like cells; its C-type lectin domain binds specifically to several carbohydrates including GalNAc, T and Tn antigen in a Ca2+-dependent manner. PMID: 12761161
    7. SRCL might be involved in selective clearance of specific desialylated glycoproteins from circulation and/or interaction of cells bearing Lewis(x)-type structures with the vascular endothelium PMID: 15845541
    8. CL-P1 is not a common membrane protein on endothelial cells found in normal tissues under steady state conditions. PMID: 18423602
    9. CL-P1 predominantly mediated phagocytosis for fungi in vascular endothelia. PMID: 19073604

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface.
  • 組織特異性：
    Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16016

    OMIM: 607621

    KEGG: hsa:81035

    STRING: 9606.ENSP00000383115

    UniGene: Hs.464422