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  4. Human Collectrin(TMEM27) ELISA kit

Human Collectrin(TMEM27) ELISA kit

  • 中文名稱：
    人Collectrin蛋白/跨膜蛋白27(TMEM27)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL023823HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人Collectrin蛋白/跨膜蛋白27(TMEM27)酶聯(lián)免疫試劑盒（CSB-EL023823HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿,組織勻漿、細胞裂解物樣本中的TMEM27含量。Collectrin（TMEM27）是一種跨膜蛋白，與ACE2同源，主要在腎臟近端腎小管和集合管表達。其研究機制涉及氨基酸轉(zhuǎn)運，與肥胖癥、糖尿病等代謝性疾病相關(guān)。研究表明，Collectrin在維持血壓穩(wěn)定和調(diào)節(jié)腎臟功能中發(fā)揮重要作用。試劑盒檢測范圍為56 pg/mL-800 pg/mL，可為科研人員探究TMEM27在代謝調(diào)控、腎臟功能及相關(guān)疾病模型中的作用提供可靠工具。適用于體外樣本檢測，操作便捷且重復性良好，可廣泛用于基礎(chǔ)研究領(lǐng)域，如通過分析不同處理條件下細胞或動物模型中TMEM27的表達變化，揭示其在能量代謝、器官發(fā)育或病理進程中的分子機制，為相關(guān)疾病的機制探索及潛在治療靶點研究提供數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    UNQ679 ELISA Kit; Collectrin ELISA Kit; kidney-specific membrane protein ELISA Kit; NX-17 ELISA Kit; NX17 ELISA Kit; PRO1312 ELISA Kit; Tmem27 ELISA Kit; TMM27_HUMAN ELISA Kit; Transmembrane protein 27 ELISA Kit; UNQ679/PRO1312 ELISA Kit
  • 縮寫：
    TMEM27
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma,tissue homogenates, cell lysates
  • 檢測范圍：
    56 pg/mL-800 pg/mL
  • 靈敏度：
    24 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Metabolism
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<15%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<15%

    Three samples of known concentration were tested in twenty assays to assess.

  • 標準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    pg/ml

    OD1

    OD2

    Average

    Corrected

    800

    2.715

    2.852

    2.784

    2.734

    400

    1.507

    1.426

    1.467

    1.417

    280

    0.861

    0.834

    0.848

    0.798

    144

    0.372

    0.399

    0.386

    0.336

    56

    0.160

    0.153

    0.157

    0.107

    0

    0.048

    0.051

    0.050

    　

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication.
  • 基因功能參考文獻：
    1. Maternal serum collectrin levels are significantly lower in patients with preeclampsia than in the control group. There is an inverse correlation between serum collectrin levels and blood pressure. PMID: 28764560
    2. Lack of expression of the TMEM27 in conventional renal cell carcinoma defines a group of patients at high risk for cancer-related death. PMID: 27417314
    3. Tmem27 is present in human serum and its levels are significantly lower in subjects with autoimmune diabetes as compared to healthy individuals. PMID: 24693993
    4. Bace2 specifically targets Tmem27 and cleaves its extracellular domain, which is then shed from the plasma membrane of pancreatic beta cells. PMID: 21907142
    5. Tmem27 dimerization is a dynamic process involving Bace2 PMID: 22628310
    6. Collectrin and ACE2 in renal and intestinal amino acid transport. PMID: 21814048
    7. Data support a role for TMEM27 in glucose-induced insulin secretion but not in cell proliferation. The finding that its cleavage is not specific to beta cells challenges the current support for its use as a potential beta cell mass biomarker. PMID: 20386877
    8. Collectrin has a role in amino acid transpor in the kidney [review] PMID: 17693757
    9. the first human study of the gene TMEM27 and an attempt to shine a light on genotype-phenotype correlation in Turner syndrome patients. PMID: 19417552
    10. No TMEM27 gene mutations were discovered among 26 patients showing a phenotype resembling Dent's disease PMID: 19582483

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    TMEM27 family
  • 組織特異性：
    Kidney; collecting ducts. Pancreas; beta cells of islets.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29437

    OMIM: 300631

    KEGG: hsa:57393

    STRING: 9606.ENSP00000369699

    UniGene: Hs.129614