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  4. Human Complement C1q tumor necrosis factor-related protein 1(C1QTNF1/CTRP1) ELISA Kit

Human Complement C1q tumor necrosis factor-related protein 1(C1QTNF1/CTRP1) ELISA Kit

  • 中文名稱：
    人補(bǔ)體C1q腫瘤壞死因子相關(guān)蛋白1(C1QTNF1/CTRP1)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E16713h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人補(bǔ)體C1q腫瘤壞死因子相關(guān)蛋白1(C1QTNF1/CTRP1)酶聯(lián)免疫試劑盒（CSB-E16713h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的C1QTNF1含量。C1QTNF1是一個值得關(guān)注的靶點。目前關(guān)于其具體背景需更多研究明確。其研究機(jī)制方面也在探索中，可能在相關(guān)生理、病理過程中發(fā)揮重要作用，后續(xù)研究或圍繞其作用途徑、與疾病關(guān)聯(lián)等深入開展，以助力疾病治療新策略的研發(fā)。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，靈敏度為0.078 ng/mL。通過特異性抗體對實現(xiàn)靶標(biāo)的高效捕獲與檢測，適用于基礎(chǔ)科研中探索CTRP1在代謝性疾病模型中的功能調(diào)控、炎癥信號通路研究，或作為生物標(biāo)志物在動物實驗及細(xì)胞實驗中的定量分析工具，為揭示其在能量代謝、脂肪組織功能及慢性疾病發(fā)生發(fā)展中的作用提供可靠檢測方案。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    C1q and tumor necrosis factor related protein 1 ELISA Kit; C1QT1_HUMAN ELISA Kit; C1QTNF1 ELISA Kit; Complement C1q tumor necrosis factor related protein 1 ELISA Kit; Complement C1q tumor necrosis factor-related protein 1 ELISA Kit; CTRP 1 ELISA Kit; CTRP1 ELISA Kit; FLJ90694 ELISA Kit; G protein coupled receptor interacting protein 1 ELISA Kit; G protein-coupled receptor-interacting protein ELISA Kit; GIP ELISA Kit; ZSIG37 ELISA Kit
  • 縮寫：
    C1QTNF1
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human CTRP1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 98
    Range % 94-102
    1:2 Average % 102
    Range % 97-107
    1:4 Average % 91
    Range % 87-95
    1:8 Average % 104
    Range % 97-108
  • 回收率：
    The recovery of human CTRP1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 91 87-95
    EDTA plasma (n=4) 103 98-107
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    20 2.274 2.312 2.293 2.190
    10 1.258 1.354 1.306 1.203
    5 0.698 0.735 0.717 0.614
    2.5 0.430 0.447 0.439 0.336
    1.25 0.275 0.288 0.282 0.179
    0.625 0.174 0.184 0.179 0.076
    0.312 0.139 0.147 0.143 0.040
    0 0.102 0.103 0.103 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻(xiàn)：
    1. CTRP1 has a role in linking dysregulation of lipid metabolism and inflammatory responses in macrophages PMID: 27175610
    2. High serum CTRP1 level is associated with Type 2 diabetes mellitus. PMID: 28207876
    3. In cultured endothelial cells, treatment of CTRP1 led to increased permeability to fluorescent-labelled dextran and apparent formation of paracellular holes as observed after disturbed flow exposure, which was evidently reduced in the presence of a CTRP1-specific neutralizing antibody. PMID: 28625919
    4. Increased serum CTRP 1 levels were closely associated with the prevalence and severity of CAD, it might be regarded as a marker for myocardial infarction. PMID: 27169633
    5. the strong association of CTRP1 with insulin resistance in NAFLD PMID: 25767880
    6. The levels of circulating CTRP1 are associated with coronary artery disease in men. PMID: 24945145
    7. The variation of plasma CTRP-1 and IL-6 concentrations may play an important role in reflecting the degree of inflammation in CHD and the severity of coronary arterial atherosclerosis. PMID: 25635749
    8. Increased plasma CTRP1 was independently associated with type 2 diabetes. Profiling of plasma adipokines such as CTRP1 is particularly important to obtain a greater understanding of their contribution to the type 2 diabetic state. PMID: 24965225
    9. CTRP1 is a novel adipokine associated with type 2 diabetes mellitus in humans. PMID: 24827430
    10. CTRP1 level was significantly higher in subjects with metabolic syndrome compared to healthy subjects. PMID: 23000311
    11. The review describes the potential role of C1qTNF1 as an intracellular regulator of signal transduction PMID: 16386877
    12. molecular cloning, gene expression, and subcellular localization of GIP PMID: 12409230
    13. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues. PMID: 16806199
    14. CTRP1 enhances the production of aldosterone. CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension. PMID: 18171693
    15. CTRP1 may be considered a novel adipokine, providing an important framework to further address the physiological functions and mechanisms of the action of this family of secreted glycoproteins in normal and disease states. PMID: 18783346

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  • 亞細(xì)胞定位：
    Secreted.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14324

    OMIM: 610365

    KEGG: hsa:114897

    STRING: 9606.ENSP00000340864

    UniGene: Hs.201398