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  4. Human Complement C2(C2) ELISA kit

Human Complement C2(C2) ELISA kit

  • 中文名稱：
    人補體C2(C2)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL003658HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人補體C2(C2)酶聯(lián)免疫試劑盒（CSB-EL003658HU）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的C2含量。試劑盒檢測范圍為15.6 ng/mL-250 ng/mL，靈敏度為15.6 ng/mL。研究者可將其應用于基礎免疫學實驗、疾病模型中的補體通路活性評估，或藥物開發(fā)過程中靶向補體系統(tǒng)的化合物篩選研究，為探索C2在病理生理機制中的作用提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    ARMD14 ELISA Kit; C2 ELISA Kit; C3/C5 convertase ELISA Kit; CO2 ELISA Kit; CO2_HUMAN ELISA Kit; Complement C2 ELISA Kit; Complement C2a fragment ELISA Kit; complement component 2 ELISA Kit; DKFZp779M0311 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    15.6 ng/mL-250 ng/mL
  • 靈敏度：
    15.6 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Competitive
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 最新研究進展：
        C2，又稱為補體蛋白C2（Complement component 2），是人體中重要的補體系統(tǒng)蛋白之一，與C1、C4等其他補體成分一起作為免疫系統(tǒng)的一部分發(fā)揮作用。C2可與其他補體成分相互作用，形成補體復合物，引發(fā)一系列補體級聯(lián)反應，最終導致病原體破壞和溶解。C2的缺失可導致免疫系統(tǒng)功能異常，易發(fā)生感染和自身免疫疾病。近年來的研究表明，C2的基因多態(tài)性與許多疾?。ㄈ缱陨砻庖咝约膊　⑿难芗膊?、肝臟疾病等）的風險相關，成為了許多疾病的潛在標志物。
     
  • 功能：
    Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
  • 基因功能參考文獻：
    1. Vag8 binding to human C1-inhibitor (C1-inh) interferes with the binding of C1-inh to C1s, C1r and MASP-2, resulting in the release of active proteases that subsequently cleave C2 and C4 away from the bacterial surface. PMID: 28742139
    2. Solution Structures of Complement C2 and Its C4 Complexes Propose Pathway-specific Mechanisms for Control and Activation of the Complement Proconvertases. PMID: 27252379
    3. The rs2844455 A allele of C2 is a risk factor for systemic lupus erythematosus development in a Chinese population, whereas the G allele might be a protective factor. PMID: 26176736
    4. our data indicate that C2 rs547154 polymorphism plays a protective role in the development of PCV. PMID: 25732348
    5. Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components. PMID: 24983375
    6. These overall results suggest a lack of strong association with the C2 and C7 gene polymorphisms to the susceptibility of systemic lupus erythematosus in the Malaysian population. PMID: 21881993
    7. Results showed that missense mutations in transmembrane protein 2 p.Ser1254Asn, interferon alpha 2 p.Ala120Thr, its regulator NLR family member X1 p.Arg707Cys, and complement component 2 p.Glu318Asp were associated with chronic hepatitis B. PMID: 22610944
    8. CFH (RS1061170), C2 (RS547154), OR CFB (RS438999) was not associated with early or late AMD. PMID: 23060141
    9. These data suggest that patients with C2 deficiency are at increased risk of Streptococcus pyogenes infections. PMID: 20417301
    10. C2 microheterogeneity and histocompatibility antigens Class I were studied in an Austrian population. PMID: 12823772
    11. study of the formation of high affinity C5 convertase of the classical pathway of complement PMID: 12878586
    12. Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2 PMID: 16670774
    13. a weaker, independent protective effect exists for complement component 2 in age related macular degeneration. PMID: 17576744
    14. These data confirm that the classical pathway is vital for complement-mediated phagocytosis of S. pneumoniae and demonstrate why subjects with a C2 deficiency have a marked increase in susceptibility to S. pneumoniae infections. PMID: 18541650
    15. Study provides insights into the genetic pathogenesis of AMD, and C2 has been shown as one of the five genes independently involved in progression from intermediate disease to advanced disease in which blindness is frequent. PMID: 19015224
    16. Upon cleavage by C1s, C2a domains undergo conformational rotation while bound to C4b and the released C2b domains may remain folded together as seen in the intact protein. PMID: 19237749

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  • 相關疾?。?/div>
    Complement component 2 deficiency (C2D)
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1248

    OMIM: 217000

    KEGG: hsa:717

    STRING: 9606.ENSP00000299367

    UniGene: Hs.408903