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  4. Human Complement factor H-related protein 2(CFHR2) ELISA kit

Human Complement factor H-related protein 2(CFHR2) ELISA kit

  • 中文名稱：
    人補(bǔ)體因子H相關(guān)蛋白2(CFHR2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL005275HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人補(bǔ)體因子H相關(guān)蛋白2(CFHR2)酶聯(lián)免疫試劑盒（CSB-EL005275HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的CFHR2含量。CFHR2屬于補(bǔ)體因子H相關(guān)基因家族，位于染色體1上，參與補(bǔ)體調(diào)節(jié)。其突變與致密性沉積病和非典型溶血性尿毒癥綜合征有關(guān)。研究顯示，CFHR2可能通過(guò)調(diào)節(jié)補(bǔ)體系統(tǒng)活性，影響脂質(zhì)代謝，在免疫調(diào)節(jié)中發(fā)揮重要作用。試劑盒檢測(cè)范圍為6.25 ng/mL-400 ng/mL，適用于體外細(xì)胞實(shí)驗(yàn)、疾病機(jī)制研究及生物標(biāo)志物探索等科研場(chǎng)景，可為補(bǔ)體相關(guān)疾病的分子機(jī)制解析、藥物靶點(diǎn)驗(yàn)證及治療策略開(kāi)發(fā)提供精準(zhǔn)的定量分析工具，尤其適合免疫學(xué)、病理學(xué)及轉(zhuǎn)化醫(yī)學(xué)領(lǐng)域的實(shí)驗(yàn)室使用本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書。
  • 別名：
    CFHL2 ELISA Kit; CFHR2 ELISA Kit; Complement factor H related protein 2 ELISA Kit; Complement factor H-related 2 ELISA Kit; Complement factor H-related protein 2 ELISA Kit; DDESK59 ELISA Kit; Factor H-related gene 2 ELISA Kit; FHR 2 ELISA Kit; FHR-2 ELISA Kit; FHR2 ELISA Kit; FHR2_HUMAN ELISA Kit; H factor (complement)-like 3 ELISA Kit; H factor like 3 ELISA Kit; H factor like protein 2 ELISA Kit; H factor-like 3 ELISA Kit; H factor-like protein 2 ELISA Kit; HFL3 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    6.25 ng/mL-400 ng/mL
  • 靈敏度：
    1.56 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human CFHR2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:100 Average % 91
    Range % 87-95
    1:200 Average % 96
    Range % 90-102
    1:400 Average % 104
    Range % 98-109
    1:800 Average % 92
    Range % 86-98
  • 回收率：
    The recovery of human CFHR2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 101 97-105
    EDTA plasma (n=4) 94 87-98
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    400 2.520 2.637 2.579 2.485
    200 2.124 2.205 2.165 2.071
    100 1.446 1.557 1.502 1.408
    50 0.937 0.923 0.930 0.836
    25 0.458 0.461 0.460 0.366
    12.5 0.271 0.283 0.277 0.183
    6.25 0.156 0.163 0.160 0.066
    0 0.093 0.095 0.094 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.
  • 基因功能參考文獻(xiàn)：
    1. Studies indicate an association between CFHR2-rs2986127 and acute anterior uveitis (AAU) diagnosis. PMID: 27306586
    2. Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR2] PMID: 27196323
    3. Thus CFHR2 likely acts in concert with factor H, as CFHR2 inhibits convertases while simultaneously allowing factor H assisted degradation by factor I. PMID: 24260121
    4. A hybrid CFHR2-CFHR5 plasma protein, arising from a chromosomal deletion mutation stabilizes the C3 convertase and reduces factor H-mediated convertase decay. PMID: 24334459
  • 亞細(xì)胞定位：
    Secreted.
  • 組織特異性：
    Expressed by the liver and secreted in plasma.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 4890

    OMIM: 600889

    KEGG: hsa:3080

    STRING: 9606.ENSP00000356385

    UniGene: Hs.632450