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  4. Human Endothelin-2(EDN2)ELISA Kit

Human Endothelin-2(EDN2)ELISA Kit

  • 中文名稱：
    人內(nèi)皮素2(EDN2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E16518h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人內(nèi)皮素2(EDN2)酶聯(lián)免疫試劑盒（CSB-E16518h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的EDN2含量。試劑盒檢測范圍為4.688 pg/mL-300 pg/mL，該產(chǎn)品適用于基礎(chǔ)科研領(lǐng)域，可用于研究EDN2在生殖生理、心血管調(diào)節(jié)或腫瘤微環(huán)境中的表達(dá)規(guī)律，為探索其分子機(jī)制、構(gòu)建疾病模型或評(píng)估藥物干預(yù)效果提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    EDN2 ELISA Kit; EDN2_HUMAN ELISA Kit; Endothelin 2 ELISA Kit; Endothelin-2 ELISA Kit; ET 2 ELISA Kit; ET-2 ELISA Kit; ET2 ELISA Kit; PPET2 ELISA Kit; Preproendothelin 2 ELISA Kit; Preproendothelin-2 ELISA Kit
  • 縮寫：
    EDN2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    4.688 pg/mL-300 pg/mL
  • 靈敏度：
    1.172 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human EDN2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 103
    Range % 96-107
    1:2 Average % 86
    Range % 81-92
    1:4 Average % 94
    Range % 87-98
    1:8 Average % 86
    Range % 80-91
  • 回收率：
    The recovery of human EDN2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 93 87-98
    EDTA plasma (n=4) 94 90-98
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    300 1.832 1.988 1.910 1.802
    150 1.214 1.192 1.203 1.095
    75 0.760 0.721 0.741 0.633
    37.5 0.442 0.451 0.447 0.339
    18.75 0.287 0.276 0.282 0.174
    9.375 0.212 0.217 0.215 0.107
    4.688 0.155 0.160 0.158 0.050
    0 0.107 0.108 0.108 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Endothelins are endothelium-derived vasoconstrictor peptides.
  • 基因功能參考文獻(xiàn)：
    1. EDN2 expression in left internal mammary arteries depends on tissue harvesting technique. PMID: 24647318
    2. Overexpression of Edn2 in the mouse retina causes an excess of tip cells and inhibits vascular growth. Overexpression of Edn2 in the brain and skin had no effect, but vascular development was inhibited in midgestation mouse embryos. PMID: 24043815
    3. Endothelin 2 and endothelin receptor type B may be a regenerative pathway for central nervous system myelination and remyelination. PMID: 23518706
    4. Studies revealed hypermethylation of EDN2 and EDN3 genes in human primary colon cancers and in a panel of human colon cancer cell lines. Epigenetic inactivation of ET-2 and ET-3 occurs frequently in both rat and human colon cancers. PMID: 22865632
    5. plasma levels of big ET-2, and big ET-3 are markedly increased in patients with end stage renal disease on hemodialysis PMID: 22921304
    6. In granulosa lutein cells from women with polycystic ovary syndrome, endothelin-2 mRNA was reduced as compared with normally ovulating women PMID: 22727793
    7. although endothelin 2 does not appear to be an independent prognostic marker, there is evidence of a putative role in clear cell renal cell carcinoma progression PMID: 22047647
    8. Endothelin-2 is a macrophage chemoattractant. ET-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia. PMID: 12207323
    9. Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells PMID: 12516960
    10. The EDN2 A985 allele, which is considered to be protective in cardiovascular disease, may be a risk factor for atrial fibrillation in patients with hypertrophic cardiomyopathy. PMID: 18037749

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Endothelin/sarafotoxin family
  • 組織特異性：
    Expressed in lung, but not in placental stem villi vessels or cultured placental villi smooth muscle cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3177

    OMIM: 131241

    KEGG: hsa:1907

    STRING: 9606.ENSP00000361668

    UniGene: Hs.1407