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  4. Human Fibroblast Growth Factor 10 (FGF10) ELISA Kit

Human Fibroblast Growth Factor 10 (FGF10) ELISA Kit

  • 中文名稱：
    人成纖維細(xì)胞生長因子10(FGF10)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E14965h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人成纖維細(xì)胞生長因子10(FGF10)酶聯(lián)免疫試劑盒（CSB-E14965h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的FGF10含量。FGF10即成纖維細(xì)胞生長因子 10，屬于FGF家族成員。它在胚胎發(fā)育、組織修復(fù)等生理過程中發(fā)揮重要作用。研究機(jī)制方面，其主要通過與受體結(jié)合激活下游信號通路，影響細(xì)胞增殖、分化、遷移等，在多種疾病如癌癥、肺疾病等研究中受關(guān)注。試劑盒檢測范圍為3.12 pg/mL-200 pg/mL，支持科研人員探究FGF10在肺纖維化、慢性炎癥性疾病模型中的表達(dá)動(dòng)態(tài)，或用于干細(xì)胞分化、再生醫(yī)學(xué)等基礎(chǔ)研究領(lǐng)域，為解析FGF10信號通路及其在組織穩(wěn)態(tài)中的作用提供可靠工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    BB213776 ELISA Kit; fd11d03 ELISA Kit; FGF 10 ELISA Kit; FGF-10 ELISA Kit; FGF10 ELISA Kit; FGF10_HUMAN ELISA Kit; Fibroblast growth factor 10 ELISA Kit; Keratinocyte growth factor 2 ELISA Kit; KGF 2 ELISA Kit; Produced by fibroblasts of urinary bladder lamina propria ELISA Kit; wu:fd11d03 ELISA Kit; zgc:109774 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    3.12 pg/mL-200 pg/mL
  • 靈敏度：
    0.78 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human FGF10 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:5Average %90
    Range %85-94
    1:10Average %93
    Range %88-97
    1:20Average %100
    Range %96-105
    1:40Average %94
    Range %90-99
  • 回收率：
    The recovery of human FGF10 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9591-99
    EDTA plasma (n=4)9793-102
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    2002.872 2.939 2.906 2.715
    1002.376 2.413 2.395 2.204
    501.662 1.563 1.613 1.422
    251.087 1.048 1.068 0.877
    12.50.604 0.651 0.628 0.437
    6.250.474 0.439 0.457 0.266
    3.120.305 0.289 0.297 0.106
    00.192 0.190 0.191 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
  • 基因功能參考文獻(xiàn)：
    1. We report the ophthalmological and genetic study of a 19-year-old woman and her relatives suffering from this syndrome. A new probably pathogenic variant is described in the FGF10 gene. PMID: 29053399
    2. We have revealed significant association of FGFR2 and MAP3K1 polymorphisms with breast cancer. PMID: 29372690
    3. data suggest that the strongest signal of association at 5p12 is mediated through coordinated activation of FGF10 and MRPS30, two candidate genes for breast cancer pathogenesis PMID: 27640304
    4. Fgf10 signaling has an essential role in the formation of lipofibroblasts during late lung development PMID: 26511927
    5. Expression of Fibroblast Growth Factor 10 is correlated with poor prognosis in gastric adenocarcinoma. PMID: 26268776
    6. FGF10 has a role in protecting neuron against oxygen-glucose deprivation injury through inducing heme oxygenase-1 PMID: 25446127
    7. Data identify autocrine activation of FGF signaling as an essential mechanism in promoting Pten-deficient skin tumors. PMID: 24582960
    8. The therapeutic potential of the FGF10 treatment. PMID: 24865969
    9. FGF10 plays an important role for tumor growth by both paracrine and autocrine manner. PMID: 24320134
    10. The findings show that immunohistochemistry with FGF10, FGFR2b, or SHH could be useful in differentiating CCAM from type I PPB, when a child presents with a focal cystic lung lesion. PMID: 24004862
    11. Paracrine FGF10 signaling stimulates the differentiation of human stem cell into urothelial cells. PMID: 23949743
    12. High FGF10 expression is associated with ameloblastoma. PMID: 24002438
    13. Three FGF10 single nucleotide polymorphisms in complete linkage disequilibrium--rs339501, rs12517396, and rs10462070--were associated with extreme myopia in the Japanese population. PMID: 24265547
    14. FGF-10 expression during the development of the human hindgut and anorectum suggests that it may play a role in hindgut and anorectal morphogenesis. PMID: 23774963
    15. The sclera of myopic eyes had higher FGF10 levels. The risk G allele of SNP rs339501 was associated with extreme myopia in human and caused a higher gene expression in the luciferase assay. PMID: 23599340
    16. the posttranslational and transcriptional mechanisms underlying stimulation of P-glycoprotein function and expression by keratinocyte growth factor-2 (KGF2) that may contribute to the beneficial effects of KGF2 in intestinal inflammatory disorders PMID: 23328208
    17. tooth agenesis had increased risk of a family history of cancer. tooth agenesis was associated with positive self-reported family history of cancer and variants in FGF10. PMID: 23169889
    18. Identification of FGF-10 at both protein and mRNA levels in ovaries from fetuses, girls, and women suggests that FGF-10 contributes to preantral follicle development; FGF-10 is expressed in both granulosa cells and oocytes. PMID: 22877940
    19. Our data suggest that common variants in FGF10 increase the risk for a wide range of non-syndromic limb deficiencies. PMID: 22965740
    20. [review] FGF10 mediates biological responses by activating FGF receptor 2b (FGFR2b) in a paracrine manner. PMID: 21696361
    21. The relationship between human ISL1 and FGF10 within the embryonic time window during which the linear heart tube remodels into four chambers, was examined. PMID: 22303449
    22. Investigation of the pulmonary functions of COPD patients heterozygous for loss of function mutations in the FGF10 gene was performed. The patients show a significant decrease in lung function parameters when compared to control values. PMID: 21742743
    23. Gremlin-mediated BMP inhibition results in activation of epithelial cells and transient fibrosis, but also induction of epithelium-protective FGF10 PMID: 20705941
    24. FGF2 and FGF10 regulate migratory activity of ovine trophoblast cells through MAPK-dependent pathways. PMID: 21310815
    25. FGF10 can promote the adipogenesis effect in situ. PMID: 19915940
    26. There was no association among gene FGFR1 rs13317, p. E467K, p. M369I, p. S393S and gene FGF10 rs1448037 and nonsyndromic cleft lip with or without palate in Chinese population. PMID: 19727229
    27. These results suggested that Thr-114 is a crucial functional residue for FGF10, and mutating Thr-114 to Ala or Arg would lead to great decrease in receptor-binding affinity and biological activity of FGF10. PMID: 20036575
    28. FGF10 upregulates Na(+)-K(+)-exchanging ATPase via the MAPK pathway. PMID: 12804770
    29. FGF-10 attenuates H2O2-induced alveolar epithelium DNA damage by mechanisms that involve activation of Grb2-SOS/Ras/RAF-1/ERK1/2 pathway and DNA repair. PMID: 14975937
    30. Fgf10 mRNA is overexpressed in a subset of human breast carcinomas. PMID: 15208658
    31. Data validate the symmetric two-end model of fibroblast growth factor (FGF) receptor (FGFR) dimerization and FGF binding and argue against the asymmetric model of FGFR dimerization. PMID: 15632068
    32. We suggest that haploinsufficiency for FGF10 during a crucial stage of development results in ALSG. PMID: 15654336
    33. Human embryonic pancreatic mesenchyme expresses FGF10, which might be used used to expand human embryonic pancreatic epithelial cells. PMID: 15690149
    34. Human recombinant FGF10 maintains murine Notch activation and induces the expansion of murine pancreatic precursors while blocking their differentiation. PMID: 16323074
    35. Localization of the FGF-10 receptor to the urothelial layer is clinically significant because intravesical administration of FGF-10 may provide a means to control the turnover of transitional epithelium in bladder disorders such as interstitial cystitis. PMID: 16597614
    36. Activation of Toll-like receptor 2 (TLR2) or Toll-like receptor 4 (TLR4) inhibited FGF-10 expression, leading to abnormal saccular airway morphogenesis. PMID: 17071719
    37. R80S and G138E mutations are associated with aplasia of the lacrimal and salivary glands. PMID: 17213838
    38. a nuclear localization signal-like motif of FGF-10 is a partial determinant of its intracellular distribution and is necessary for its mitogenic activity PMID: 17471512
    39. Trophoblast outgrowth and invasion (part of placental villi sprouting) at the fetal maternal interface is in part under delicate control of FGF 10 and Sprouty 2. PMID: 17496316
    40. Results suggest that Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway. PMID: 17682060
    41. Expression in diverse niches of adult brain of Fgf10-lacZ reporter mice implicates Fgf10 in control of neurogenesis and/or conservation of neurogenic potential. PMID: 18329286
    42. It cannot be ruled out that other genes involved in the signalling pathway of FGF10 may contribute to the formation of these congenital malformations. PMID: 18587586
    43. Stromal FGF10 induces migration and invasion in pancreatic cancer cells through interaction with FGFR2, resulting in a poor prognosis. PMID: 18594526
    44. family-based approach revealed an intronic variation of the FGF10 gene causing aplasia of lacrimal and salivary glands-syndrome PMID: 19102732
    45. Disruption of localized pattern of mesenchymal fibroblast growth factor 10 expression results in impairment of lung branching morphogenesis, which progresses to emphysematous airspaces in adults. PMID: 19115389
    46. Fgf10 is a strong causative candidate for defects observed in Apert syndrome since its genetic knockdown in a mouse model of Apert syndrome results in the rescue of the skeletal and visceral defects associated with this congenital disease. PMID: 18773495
    47. An analysis of the distribution and fate of Fgf10-expressing cells in the adult mouse brain suggests that Fgf10 may have critical regulatory roles in stem cell function and generation of new neurons in diverse areas of the adult brain. PMID: 18773495
    48. TGFbeta1 caused a rapid and transient decrease in Fgf10 mRNA levels in primary prostatic cells. Deletion analysis of the Fgf10 promoter identified a region that mediated a proportion of promoter activity as well as promoter down-regulation by TGFbeta1. PMID: 14726452

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  • 相關(guān)疾?。?/div>
    Aplasia of lacrimal and salivary glands (ALSG); Lacrimo-auriculo-dento-digital syndrome (LADDS)
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Heparin-binding growth factors family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3666

    OMIM: 149730

    KEGG: hsa:2255

    STRING: 9606.ENSP00000264664

    UniGene: Hs.248049