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  4. Human Fibroblast growth factor 18(FGF18) ELISA kit

Human Fibroblast growth factor 18(FGF18) ELISA kit

  • 中文名稱：
    人成纖維細(xì)胞生長因子18(FGF18)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL008623HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人成纖維細(xì)胞生長因子18(FGF18)酶聯(lián)免疫試劑盒（CSB-EL008623HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的FGF18含量。FGF18即成纖維細(xì)胞生長因子18，在胚胎發(fā)育、組織修復(fù)與再生等過程發(fā)揮關(guān)鍵作用。研究主要聚焦其信號通路機(jī)制，它可與特定受體結(jié)合激活下游信號，影響細(xì)胞增殖、分化等活動，在骨疾病、腫瘤等疾病治療領(lǐng)域有潛在應(yīng)用價值。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，支持骨骼生物學(xué)研究、軟骨再生機(jī)制探索、藥物篩選模型中FGF18表達(dá)動態(tài)監(jiān)測以及相關(guān)疾病的分子機(jī)制解析等基礎(chǔ)研究領(lǐng)域本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    FGF 18 ELISA Kit; FGF-18 ELISA Kit; Fgf18 ELISA Kit; FGF18_HUMAN ELISA Kit; FGFI ELISA Kit; Fibroblast growth factor 18 ELISA Kit; zFGF5 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human FGF18 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1 Average % 99    
    Range % 89-107    
    1:2 Average % 92    
    Range % 87-96    
    1:4 Average % 95    
    Range % 90-100    
    1:8 Average % 98    
    Range % 94-103    
  • 回收率：
    The recovery of human FGF18 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 102 96-108    
    EDTA plasma (n=4) 96 92-100    
                   
                   
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    pg/ml OD1 OD2 Average Corrected    
    2000 2.303 2.227 2.265 2.113    
    1000 1.685 1.765 1.725 1.573    
    500 1.182 1.163 1.173 1.021    
    250 0.809 0.815 0.812 0.660    
    125 0.466 0.454 0.460 0.308    
    62.5 0.344 0.334 0.339 0.187    
    31.25 0.220 0.228 0.224 0.072    
    0 0.152 0.151 0.152 　    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.
  • 基因功能參考文獻(xiàn)：
    1. FGF18 played an important role in the growth and metastasis of breast cancer. PMID: 29901199
    2. we genotyped rs9313548 and performed case-control-based association analysis with developmental dyslexia in a Chinese population. Our results were in consistent with previous studies as we did not observe significant association of rs9313548 with developmental dyslexia. PMID: 29240020
    3. the suppressive effect of miR-139 on FGF18 and in turn on proliferation, apoptosis, invasion, migration and tumor-induced angiogenesis of HCC cells was investigated. FGF18 was suggested as a prognostic biomarker and therapeutic target in HCC patients and miR-139 may be a promising strategy used in HCC treatment via the suppression of FGF18 PMID: 28765917
    4. the results suggest that FGF18 may be involved in MC3T3E1 cell proliferation and osteoblastic differentiation. PMID: 28765932
    5. significantly increased in endometrioid adenocarinoma PMID: 27267714
    6. FGF9 and FGF18 increased the migratory capacities of human lung fibroblasts, and FGF9 actively modulated matrix metalloproteinase activity in idiopathic pulmonary fibrosis. PMID: 26773067
    7. FGF18 serves an essential role in the growth and migration of non-small cell lung cancer cells by regulating the ERK, p38 signaling pathways and MMP26 protein levels. PMID: 27959447
    8. Data suggest that the combination of FIGO stage, ovarian carcinoma type, and/or fibroblast growth factor 18 (FGF18) score could predict poor prognosis among ovarian carcinoma patients. PMID: 26427667
    9. The position of sulfate ions bound to FGF18 provides insight into the putative HS-binding site and allows comparison with the prototypical FGFs, FGF1, and FGF2. PMID: 24668462
    10. role for FGF-18 in chondrogenic and osteogenic events which drive discal development and ossification of the vertebral bodies. PMID: 23397188
    11. Fgf18 as a molecule that protects articular cartilage by gene expression profiling, and the anticatabolic effects may at least partially be mediated by the Timp1 expression. PMID: 24577103
    12. Tumors from ovarian cancer patients had increased FGF18 expression levels with microvessel density and M2 macrophage infiltration. PMID: 24018557
    13. FGF8, FGF17, and FGF18 are involved in autocrine and paracrine signaling in HCC and enhance the survival of tumor cells under stress conditions, malignant behavior, and neoangiogenesis. PMID: 21319186
    14. There was an association between gene FGF18 rs4043716 and nonsyndromic cleft lip with or without palate in Chinese population. PMID: 19727229
    15. FGF2 and -18 bind to discrete structures on the heparan sulfate chains attached to chondrocyte-derived perlecan which modulate the growth factor activities PMID: 20507176
    16. fibroblast growth factor 18 seems to play a role in maintenance of chondrocyte properties, although its expression was rather high in dedifferentiated chondrocytes. PMID: 19909293
    17. analysis of FGF18 and FGFR5 expression in primary endothelial cells and vascular smooth muscle cells PMID: 16019430
    18. FGF18 is wildly expressed in the cardiovascular tissue. It enhanced cell migration in response to mechanical damage. we detected FGF18 expression in liver vascular and liver sinusoidal endothelial cells (LSECs), but not in hepatic parenchymal cells. PMID: 16756958
    19. FGF18 may play a prominent role in chondrogenesis and osteogenesis during skeletal development and growth (review) PMID: 17128416
    20. FGF3, FGF7, FGF10, FGF18, and FGFR1 may have roles in nonsyndromic cleft lip and palate PMID: 17360555
    21. FGF18 is almost generally over-expressed in colon cancer and exerts pro-tumorigenic effects both in the epithelial and the stromal compartments by stimulating growth and survival of tumour cells, migration of fibroblasts and neovascularization PMID: 17890768

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Heparin-binding growth factors family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3674

    OMIM: 603726

    KEGG: hsa:8817

    STRING: 9606.ENSP00000274625

    UniGene: Hs.87191