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  4. Human Gastrokine-1(GKN1) ELISA kit

Human Gastrokine-1(GKN1) ELISA kit

  • 中文名稱：
    人胃動(dòng)蛋白1(GKN1)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL009469HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人胃動(dòng)蛋白1(GKN1)酶聯(lián)免疫試劑盒（CSB-EL009469HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的GKN1含量。試劑盒檢測(cè)范圍為0.625 ng/mL-40 ng/mL，該產(chǎn)品可用于基礎(chǔ)科研中探索GKN1在消化系統(tǒng)疾病中的分子調(diào)控機(jī)制、評(píng)估其作為潛在生物標(biāo)志物的價(jià)值，或用于體外藥物干預(yù)實(shí)驗(yàn)中對(duì)胃黏膜保護(hù)劑、抗腫瘤藥物等候選化合物的效果評(píng)價(jià)。本產(chǎn)品僅限科學(xué)研究使用本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    18 kDa antrum mucosa protein ELISA Kit; AMP 18 ELISA Kit; AMP-18 ELISA Kit; AMP18 ELISA Kit; Antrum mucosa protein, 18-KD ELISA Kit; BRICD 1 ELISA Kit; BRICD1 ELISA Kit; BRICHOS domain containing 1 ELISA Kit; CA 11 ELISA Kit; CA11 ELISA Kit; CA11 gene ELISA Kit; CA11 protein ELISA Kit; FOV ELISA Kit; Foveolin ELISA Kit; Gastrokine-1 ELISA Kit; Gastrokine1 ELISA Kit; GKN 1 ELISA Kit; Gkn1 ELISA Kit; GKN1_HUMAN ELISA Kit; MGC70354 ELISA Kit; Protein CA11 ELISA Kit; UNQ489/PRO1005 ELISA Kit
  • 縮寫(xiě)：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.625 ng/mL-40 ng/mL
  • 靈敏度：
    0.156 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Tags & Cell Markers
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
  • 基因功能參考文獻(xiàn)：
    1. Data show that ubiquitin protein ligase E3 component n-recognin 5 protein (UBR5) bound the tumor suppressor gastrokine 1 (GKN1) and increased its ubiquitination to reduce the protein stability of GKN1. PMID: 27590582
    2. These results did not confirm GKN1 as a potential biomarker for gastric cancer. PMID: 27452910
    3. Low GKN1 expression is associated with gastric cancer. PMID: 27250838
    4. GKN1 may contribute to the maintenance of gastric epithelial homeostasis and inhibit gastric carcinogenesis by down-regulating the gastrin-cholecystokinin B receptor signaling pathway. PMID: 25752269
    5. Gastrokine 1 indirectly participates in actin stabilization since its overexpression in gastric cancer cells strongly increases the expression of tight and adherens junction proteins PMID: 26008777
    6. AMP-18 appears to act through PI3K/AKT pathways to increase p21 phosphorylation, thereby reducing its nuclear accumulation to overcome the antiproliferative effects of TNF-alpha. PMID: 25919700
    7. Results suggest a potential association between CRP and GPC5 variants with lung cancer risk; variation in GKN1 is associated with chemotherapy response in the Chinese Han population. PMID: 25999661
    8. GKN1 inhibits metastasis in gastric cancer cells. PMID: 25725220
    9. GKN1 may shorten telomeres by acting as a potential c-myc inhibitor that eventually leads to senescence and apoptosis in gastric cancer cells PMID: 25344918
    10. GKN1 expression in the gastric mucosa of gastric cancer patients is decreased; this is associated with progression and prognosis of gastric cancer. PMID: 25469040
    11. Data show that recombinant gastrokine 1 (GKN1) interacts with amyloid-beta peptide (1-40) preventing its aggregation. PMID: 25139219
    12. These results suggest that GKN1 might be a target to inhibit the effects from H.pylori CagA. PMID: 25239641
    13. Low GKN1 activity is associated with gastric cancers. PMID: 23812904
    14. Epstein-Barr virus EBNA1 binds to the divergent promoter of the GKN1 and GKN2 genes and contributes to the complex transcriptional and epigenetic deregulation of the GKN1 and GKN2 tumor suppressor genes. PMID: 24460791
    15. Our results show that GKN1 has an miR-185-dependent and -independent mechanism for chromatic and DNA epigenetic modification, thereby regulating the cell cycle PMID: 23846337
    16. Data suggest GKN1 is expressed in placental trophoblasts in third trimester (not first); GKN1 expression is limited to extravillous trophoblasts. GKN1 expression is downregulated in choriocarcinoma; GKN1 attenuates migration of choriocarcinoma cells. PMID: 23993393
    17. These data demonstrate that in the presence of GKN2, GKN1 loses its ability to decrease cell proliferation, induce apoptosis, and inhibit epigenetic alterations in gastric cancer cells. PMID: 24151046
    18. these results suggest that the NH2-terminal hydrophobic region and BRICHOS domain of GKN1 are sufficient for its tumor suppressor activities. PMID: 24099765
    19. the GKN1 gene may inhibit progression of gastric epithelial cells to cancer cells by regulating NF-kappaB signaling pathway and cytokine expression. PMID: 23444260
    20. Molecular and functional properties of human GKN1 indicate a more significant propensity for beta-sheet structures. PMID: 23319233
    21. Low expression of gastrokine 1 is associated with gastric cancer. PMID: 23317277
    22. Expression of GKN1 is progressively lost from normal mucosa, precancerous to cancerous gastric tissues, while restoration of GKN1 expression induces gastric cancer cells to undergo apoptosis. PMID: 22621392
    23. There is no direct molecular interaction between GKN1 and TFF1 in protein level in gastric cancer. PMID: 22842654
    24. Both Helicobacter pylori infection and long-term non-steroidal anti-inflammatory drug administration downregulate gastrokine-1 expression in the gastric mucosa, which may contribute to the gastric mucosal injuries induced by these two factors. PMID: 22798109
    25. GKN1 inhibits gastric cancer cell proliferation. PMID: 21751384
    26. The GKN1 gene may play an important role in the progression of sporadic gastric cancers via inhibition of EMT and cancer cell migration PMID: 21898090
    27. GKN1 modulates apoptotic signals and might play an important role for tissue repair during the early stages of neoplastic transformation. PMID: 21792914
    28. AMP-18 could protect the intestinal mucosal barrier by acting on specific tight junction proteins and stabilizing perijunctional actin PMID: 15961882
    29. study demonstrated the presence of gastrokine-1 isoforms of which the basic isoform was reduced in a subset of patients with H. pylori infection. PMID: 17092786
    30. GKN1 and GKN2 expression occurs frequently in gastric adenocarcinomas, especially in the diffuse subtype PMID: 18593995
    31. GKN1 expression is related to the inflammatory damage of gastric mucosa and could be the related to the gastric cellular phenotype. PMID: 18927498

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  • 亞細(xì)胞定位：
    Secreted. Cytoplasmic granule. Golgi apparatus.
  • 蛋白家族：
    Gastrokine family
  • 組織特異性：
    Expressed in stomach (at protein level). No expression is detected in cancer tissue or gastric cancer cell lines.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 23217

    OMIM: 606402

    KEGG: hsa:56287

    STRING: 9606.ENSP00000367172

    UniGene: Hs.69319