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  4. Human Gastrotropin(FABP6) ELISA kit

Human Gastrotropin(FABP6) ELISA kit

  • 中文名稱：
    人脂肪酸結(jié)合蛋白6(FABP6)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL007955HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人脂肪酸結(jié)合蛋白6(FABP6)酶聯(lián)免疫試劑盒（CSB-EL007955HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的FABP6含量。FABP6即脂肪酸結(jié)合蛋白6，在腸道膽汁酸轉(zhuǎn)運(yùn)等過(guò)程中發(fā)揮作用。其研究機(jī)制主要聚焦在與膽汁酸代謝調(diào)控、脂代謝的關(guān)聯(lián)方面。探索其作用機(jī)制，有望為膽汁酸相關(guān)疾病、脂質(zhì)代謝紊亂疾病等的治療提供新的靶點(diǎn)和思路。試劑盒檢測(cè)范圍為0.312 ng/mL-20 ng/mL，該產(chǎn)品適用于基礎(chǔ)科研中探索FABP6在腸道功能、代謝性疾病或癌癥發(fā)生發(fā)展中的作用機(jī)制，也可用于評(píng)估不同實(shí)驗(yàn)條件下（如藥物處理、基因編輯）細(xì)胞或動(dòng)物模型中FABP6的表達(dá)變化，為營(yíng)養(yǎng)學(xué)、藥理學(xué)及病理學(xué)研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    Fabp6 ELISA Kit; FABP6_HUMAN ELISA Kit; Fatty acid binding protein 6; ileal (gastrotropin) ELISA Kit; Fatty acid-binding protein 6 ELISA Kit; Gastrotropin ELISA Kit; GT ELISA Kit; I 15P ELISA Kit; I BABP ELISA Kit; I BALB ELISA Kit; I BAP ELISA Kit; I-15P ELISA Kit; I-BABP ELISA Kit; I15P ELISA Kit; IBABP ELISA Kit; IBALB ELISA Kit; IBAP ELISA Kit; ILBP ELISA Kit; ILBP3 ELISA Kit; Ileal lipid binding protein ELISA Kit; Ileal lipid-binding protein ELISA Kit; ILLBP ELISA Kit; Intestinal 15 kDa protein ELISA Kit; Intestinal bile acid binding protein ELISA Kit; Intestinal bile acid-binding protein ELISA Kit
  • 縮寫(xiě)：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類(lèi)型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測(cè)范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human gastrotropin in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 90
    Range % 82-94
    1:2 Average % 97
    Range % 91-101
    1:4 Average % 94
    Range % 85-97
    1:8 Average % 90
    Range % 84-95
  • 回收率：
    The recovery of human gastrotropin spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 100 91-104
    EDTA plasma (n=4) 92 88-96
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    20 2.266 2.189 2.228 2.075
    10 1.649 1.676 1.663 1.510
    5 0.961 0.924 0.943 0.790
    2.5 0.633 0.629 0.631 0.478
    1.25 0.355 0.364 0.360 0.207
    0.625 0.250 0.266 0.258 0.105
    0.312 0.199 0.187 0.193 0.040
    0 0.154 0.152 0.153 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion.; Essential for the survival of colon cancer cells to bile acid-induced apoptosis.
  • 基因功能參考文獻(xiàn)：
    1. Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR PMID: 26613247
    2. Analysis of slow and fast motions in I-BABP indicates largely different energy landscapes for the apo and holo states suggesting that optimization of binding interactions might be achieved by altering the dynamic behavior of specific protein segments. PMID: 25073073
    3. show, using electrospray ionization mass spectroscopy, that human ILBP binds bile acids with a 3:1 ratio, even at low protein and ligand concentrations PMID: 23758264
    4. Ursodeoxycholic acid induces unique conformational changes in IBABP. PMID: 22223860
    5. NMR data are in agreement with a conformational selection model we proposed earlier for I-BABP and support the hypothesis of an allosteric mechanism of ligand binding PMID: 22329738
    6. The-putative functional-Thr79Met substitution of FABP6 confers a protective effect on type 2 diabetes in obese individuals. PMID: 19744871
    7. NMR structure of human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures PMID: 12486725
    8. the I-BABP gene may be a novel target for PPAR in humans PMID: 15936983
    9. ASBT and ILBP protein were 48% and 67% lower in normal weight gallstone carriers than in controls (P < 0.05); similar differences were found for mRNA expression levels. PMID: 16237211
    10. The expression of FABP6 was higher in primary colorectal cancers and adenomas than in normal epithelium, but was dramatically decreased in lymph node metastases, suggesting that FABP6 may play an important role in early carcinogenesis. PMID: 16951225
    11. In keeping with its role in the enterohepatic circulation and ileal reabsorption of bile acids, the gene promoter contains consensus elements for CDX2 and FXR. More than one transcription start site has been identified. PMID: 14654244

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  • 亞細(xì)胞定位：
    [Isoform 1]: Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 組織特異性：
    Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in c
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3561

    OMIM: 600422

    KEGG: hsa:2172

    STRING: 9606.ENSP00000377549

    UniGene: Hs.519719