Human Glucose dependent insulin releasing polypeptide,GIP ELISA Kit
-
中文名稱:人葡萄糖依賴性胰島素釋放多肽(GIP)酶聯(lián)免疫試劑盒
-
貨號:CSB-E08484h
-
規(guī)格:96T/48T
-
價格:¥3200/¥2500
-
其他:
產(chǎn)品詳情
-
產(chǎn)品描述:人葡萄糖依賴性胰島素釋放多肽(GIP)酶聯(lián)免疫試劑盒(CSB-E08484h)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的GIP含量。GIP(葡萄糖依賴性促胰島素釋放多肽)是一種腸促胰島素,主要作用是刺激胰島素分泌,參與血糖調(diào)節(jié)。其研究機制涉及通過激活β細(xì)胞上的GIP受體,提高胰島素分泌,改善胰島素抵抗,對糖尿病和肥胖治療具有潛在價值。試劑盒檢測范圍為12.5 ng/ml-200 ng/ml.,適用于基礎(chǔ)科研中探索GIP在代謝調(diào)控中的作用機制、評估疾病模型動物體內(nèi)激素水平變化,或用于體外研究藥物、營養(yǎng)素等干預(yù)對GIP分泌的影響。為開展胃腸激素相關(guān)分子機制研究及代謝疾病治療策略開發(fā)提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
-
別名:Gastric Inhibitory Peptide ELISA Kit; Gastric inhibitory polypeptide ELISA Kit; Gastric inhibitory polypeptide precursor ELISA Kit; GIP ELISA Kit; GIP_HUMAN ELISA Kit; Glucose dependent insulinotropic polypeptide ELISA Kit; Glucose-dependent insulinotropic polypeptide ELISA Kit; Incretin hormone ELISA Kit
-
縮寫:
-
Uniprot No.:
-
種屬:Homo sapiens (Human)
-
樣本類型:serum, plasma, tissue homogenates
-
檢測范圍:12.5 ng/ml-200 ng/ml.
-
靈敏度:2.5 ng/ml.
-
反應(yīng)時間:1-5h
-
樣本體積:50-100ul
-
檢測波長:450 nm
-
研究領(lǐng)域:Signal Transduction
-
測定原理:quantitative
-
測定方法:Sandwich
-
精密度:
-
線性度:
-
回收率:
-
標(biāo)準(zhǔn)曲線:
-
數(shù)據(jù)處理:
-
貨期:3-5 working days
引用文獻(xiàn)
- The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice C Yun,Nature metabolism,2024
- Biomarker Signatures Predicting 10-Year All-Cause and Disease-Specific Mortality Yanxia Lu.et al,journals of gerontology series a-biological sciences and medical sciences,2018
相關(guān)產(chǎn)品
相關(guān)問答
我有一個關(guān)于CSB-E08484h、CSB-E08119h和CSB-E09207h產(chǎn)品的技術(shù)問題。這些試劑盒的酶標(biāo)板是怎樣的?(標(biāo)準(zhǔn)品、對照和樣品分別占多少孔位?)
靶點詳情
-
功能:Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
-
基因功能參考文獻(xiàn):
- The genetic variability of GIP gene is associated with coronary artery disease and it may play a role in the premature coronary artery disease in the Chinese Han population with type 2 diabetes. PMID: 29765988
- The ability of a truncated form of GIP, GIP(3-30)NH2, to antagonize the physiological actions of GIP in glucose metabolism, subcutaneous abdominal adipose tissue blood flow, and lipid metabolism in humans. PMID: 28667118
- GIP and PP plasma concentrations are lower in pancreatic cancer irrespective of the degree of glucose intolerance as compared to Type 2 diabetic patients and healthy controls. PMID: 28027898
- Evening postprandial insulin and GIP responses and insulin resistance declined by over 30% after three meals that limited daily carbohydrate intake to 30% compared to no such changes after three 60%-carbohydrate meals, an effect that was independent of pre-meal exercise. PMID: 27798656
- the stimulatory effect of IGF-1 on GIP promoter support the hypothesis of a functional growth hormone-igf-1-GIP axis PMID: 28179449
- decreased maternal 25OHD may be associated with decreased cord 25OHD and increased cord GLP-1 and GIP levels, which may be involved with the transfer of maternal glucose to the fetus PMID: 26650343
- Excess androgen activity might be a factor contributing to alter secretion of incretins in lean polycystic ovary syndrome (PCOS) women. However it could not be ruled out that it is also possible that increased GIP levels might induce hyperandrogenemia in PCOS. PMID: 26895276
- Our results might indicate an altered DPP4-incretin system and altered immunoregulation including a potentially dysfunctional GLP1(9)(-)(36) signaling in T1DM. PMID: 26434625
- Fasting GIP concentrations are higher in individuals with a history of cardiovascular disease (myocardial infarction, stroke) when compared with control subjects. PMID: 26395740
- Data suggest that high levels of blood glucose or AGEs (advanced glycation end products), as seen in hyperglycemia, reduce secretion of insulin by pancreatic beta cells via antagonism of GIP (gastric inhibitory polypeptide)/GIP receptor signaling. PMID: 26221611
- Data confirm that postprandial plasma levels of glucose-dependent insulinotropic polypeptide (GIP) and insulin (INS) are responsive to glycemic index of foods consumed; glycemic index of breakfast cereals regulate plasma postprandial GIP and INS. PMID: 25852025
- irisin and GIP might contribute to the development of polycystic ovary syndrome and may also represent novel polycystic ovary syndrome biomarkers PMID: 25029417
- Data suggest that postprandial blood levels of both GIP and insulin can be regulated by diet; here, inclusion of nopal/Opuntia/cactus (a functional food in traditional Mexican medicine) in breakfast reduces postprandial levels of GIP and insulin. PMID: 25132122
- phosphatidylinositol 3-kinase gamma has a role in insulin secretion induced by glucose-dependent insulinotropic polypeptide PMID: 25288806
- These novel results support the notion that the GIP-GIPR axis plays a role in the etiology of central obesity in humans PMID: 25324507
- Data from studies in healthy Japanese men suggest that plasma GIP levels in postprandial period are dose dependently increased by fat content of meals of ordinary size, despite the amount of additional fat being relatively small. PMID: 24507870
- Patients with idiopathic gastroparesis exhibit abnormal GIP levels. PMID: 23663508
- Beta cell connectedness is an inherent property of human islets that is likely to influence incretin-potentiated insulin secretion. PMID: 24018562
- Data suggest that postprandial plasma levels of glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP1) are increased after consumption of buckwheat crackers versus rice crackers in healthy and type 2 diabetic subjects. PMID: 23485142
- GIP induces an inflammatory and prolipolytic response via the PKA -NF-kappaB-IL-1 pathway and impairs insulin sensitivity of glucose uptake in human adipocytes. PMID: 23092914
- results indicate postprandial GIP secretion in early-phase after test meal in Japanese patients with type 2 diabetes was positively correlated with BMI, but not those with type 1 diabetes PMID: 22301939
- Hyperinsulinemia subjects with metabolic syndrome showed increased GIP secretion that could be responsible for the delayed glucagon suppression. PMID: 22391044
- Data suggest that reduced insulinotropic effect of GIP or GLP-1 (as in type 2 diabetes) can be induced in healthy subjects; this indicates that reduced incretin stimulation of insulin secretion results from insulin resistance/glucose intolerance. PMID: 22319034
- GIP reduces free fatty acid release from adipose tissue by inhibition of lipolysis or by increased reesterification. PMID: 22179810
- may have a pro-obesogenic action [review] PMID: 21815989
- Studies identified some potentially important additional C-terminal interactions of GIP with its N-terminal extracellular receptor domain. PMID: 21539943
- We report that the human GIP locus was differentially selected in East Asians about 8100 years ago based on the analysis of a nonsynonymous SNP (rs2291725). PMID: 20978139
- GLP-2, but not GIP, was found to stimulate the release of glucagon in patients with T1DM, suggesting a role for GLP-2 in the postprandial hyperglucagonaemia characterising individuals with T1DM PMID: 20580750
- These results suggest that Tyr/His(1) and Ile/Thr(7) of GIP/GLP-1 peptides confer differential ligand selectivity toward GIPR and GLP1R. PMID: 20799012
- We demonstrate for the first time that changes in insulin secretion after lifestyle intervention may be mediated via alterations in GIP secretion from intestinal K-cells PMID: 20200305
- No statistically significant association was observed between any of the single nucleotide polymorphisms of GIP analysed and type 2 diabetes in our population. PMID: 20673334
- GIP is expressed in and secreted from pancreatic islets and promotes islet glucose competence and also could support islet development and/or survival. PMID: 20138041
- a binding mode of GIP to GIPR in which the N-terminal moiety of GIP was sited within transmembrane helices (TMH) 2, 3, 5, and 6 with biologically crucial Tyr1 interacting with Gln224 (TMH3), Arg300 (TMH5), and Phe357 (TMH6). PMID: 20061446
- Substitution of Glu(3) in GIP with proline produces a novel dipeptidylpeptidase IV-resistant GIP antagonist which inhibits GIP-induced cAMP generation and insulin secretion with high sensitivity and specificity in vitro. PMID: 11820780
- activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway PMID: 12138104
- Mutation in promoter region of gip receptor gene are unlikely to underlie GIP-dependent Cushing syndrome. PMID: 12530694
- Elevated plasma GIP levels are correlated with hyperinsulinemia in the impaired glucose-tolerant state, whereas type 2 diabetes is associated with a failure to secrete adequate amounts of GIP. PMID: 15220248
- bombesin and nutrients additively stimulate GIP release from GIP/Ins cells. PMID: 15383372
- Results describe the solution structure of GIP(1-30)amide, the major biologically active fragment of glucose-dependent insulinotropic polypeptide. PMID: 15522230
- GIP augments glucose-stimulated insulin secretion and acts as an endogenous inhibitor of gastric acid secretion--REVIEW PMID: 15533777
- GIP stimulates insulin secretion by potentiating events underlying membrane depolarization and exerting direct effects on exocytosis. PMID: 15955806
- The relationship between insulin resistance and the insulin secretion to GIP suggests that beta cell secretory function in response to different stimuli increases adaptively when insulin sensitivity is diminished, as in gestational diabetes. PMID: 16010522
- GIP is rapidly degraded into inactive metabolites by the enzyme dipeptidyl-peptidase-IV. (review) PMID: 16142014
- protein kinase B, LKB1, and AMP-activated protein kinase have roles in activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes PMID: 17244606
- study identified a splice site mutation of the Glucose-dependent insulinotropic polypeptide (GIP) gene which results in a truncated protein and provides evidence for association of GIP receptor genotype with cardiovascular disease PMID: 17624916
- physiologic role for GIP in lipid homeostasis and possibly in the pathogenesis of obesity. PMID: 18054552
- concomitant expression of Pax6 and Pdx1 is important for glucose-dependent insulinotropic polypeptide expression PMID: 18593849
- GIP secretion is blunted after the biliopancreatic diversion only in diabetic patients, suggesting a role in insulin resistance and diabetes. PMID: 19229515
- GIP may mediate the attenuated glucose-stimulated insulin response after exercise/diet interventions PMID: 19351807
- Inhibition of apoptosis by GIP is mediated via a key pathway involving Akt-dependent inhibition of apoptosis signal-regulating kinase 1, which subsequently prevents the pro-apoptotic actions of p38 MAPK and JNK. PMID: 19748889
顯示更多
收起更多
-
亞細(xì)胞定位:Secreted.
-
蛋白家族:Glucagon family
-
數(shù)據(jù)庫鏈接:
Most popular with customers
-
Human Transforming Growth factor β1,TGF-β1 ELISA kit
Detect Range: 23.5 pg/ml-1500 pg/ml
Sensitivity: 5.8 pg/ml
-
-
-
Mouse Tumor necrosis factor α,TNF-α ELISA Kit
Detect Range: 7.8 pg/ml-500 pg/ml
Sensitivity: 1.95 pg/ml
-
-
-
-