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  4. Human Gremlin-2(GREM2) ELISA kit

Human Gremlin-2(GREM2) ELISA kit

  • 中文名稱：
    人Gremlin-2(GREM2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL009893HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人Gremlin-2(GREM2)酶聯(lián)免疫試劑盒（CSB-EL009893HU）為競(jìng)爭(zhēng)法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的GREM2含量。Gremlin-2（GREM2）是一種分泌的糖基化蛋白，屬于BMP拮抗劑家族，主要表達(dá)于代謝相關(guān)組織。GREM2通過抑制BMP信號(hào)通路，影響脂肪細(xì)胞分化和能量代謝，在肥胖和2型糖尿病的治療中具有潛在應(yīng)用價(jià)值。試劑盒檢測(cè)范圍為6.25 pg/mL-2500 pg/mL，可廣泛應(yīng)用于細(xì)胞模型、疾病動(dòng)物實(shí)驗(yàn)及臨床前樣本分析，為探究GREM2在組織再生、纖維化病理進(jìn)程或腫瘤微環(huán)境調(diào)控中的作用提供可靠工具，助力發(fā)育生物學(xué)、病理機(jī)制及藥物干預(yù)等基礎(chǔ)研究。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    BMP antagonist 2 ELISA Kit; CKTSF1B2 ELISA Kit; Cysteine knot superfamily 1 ELISA Kit; Cysteine knot superfamily 1 BMP antagonist 2 ELISA Kit; DAN domain family member 3 ELISA Kit; DAND 3 ELISA Kit; DAND3 ELISA Kit; GREM 2 ELISA Kit; Grem2 ELISA Kit; GREM2_HUMAN ELISA Kit; Gremlin 2 ELISA Kit; Gremlin 2 cysteine knot superfamily homolog ELISA Kit; Gremlin-2 ELISA Kit; Gremlin2 ELISA Kit; PRDC ELISA Kit; Protein related to DAN and cerberus ELISA Kit
  • 縮寫：
    GREM2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    6.25 pg/mL-2500 pg/mL
  • 靈敏度：
    6.25 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Competitive
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<15%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<15%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human GREM2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:1 Average % 93  
    Range % 88-100  
    1:2 Average % 95  
    Range % 84-101  
    1:4 Average % 93  
    Range % 87-100  
    1:8 Average % 90  
    Range % 87-101  
  • 回收率：
    The recovery of human GREM2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 88 85-93  
    EDTA plasma (n=4) 95 90-99  
                 
                 
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average    
    2500 0.155 0.149 0.152    
    469 0.342 0.352 0.347    
    78 0.559 0.569 0.564    
    22 1.001 0.963 0.982    
    6.25 1.543 1.510 1.527    
    0 2.184 2.086 2.135    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.
  • 基因功能參考文獻(xiàn)：
    1. TT genotype of the rs4454537 polymorphism protective against the development of osteoporosis PMID: 30014930
    2. Our study confirmed that GREM2 is a candidate gene for tooth agenesis, which mutations can explain, however, only a small fraction of the genetic contribution to the pathogenesis of this anomaly. PMID: 28992378
    3. Data show that the GREMLIN 2 (GREM2) expression during Induced Pluripotent Stem Cell (hiPS) cell cardiac differentiation follows the expression pattern of cardiac-specific genes. PMID: 28125926
    4. The structure of Grem2-GDF5 complex has revealed a number of key findings for DAN-family mediated BMP2 inhibition. PMID: 27524626
    5. This study showed that si-Grem2 increased the BMP-2-induced osteogenic differentiation of hBMSCs via the BMP-2/Smad/Runx2 pathway. PMID: 27335248
    6. The present study shows that the Grem2 heparin/HS and BMP2-binding epitopes are unique and independent, where the Grem2-BMP2 complex exhibits a significant increase in binding affinity toward heparin moieties that appear to be partially independent of the Grem2 heparin/HS-binding epitope. PMID: 28104757
    7. Gremlin 2 inhibits adipocyte differentiation through activation of Wnt/beta-catenin signaling PMID: 26239165
    8. mutations associated with tooth malformations PMID: 26416033
    9. GREM2 variants have been identified in atrial fibrillation cohort studies, demonstrating abnormalities in cardiac excitation - supra ventricular tachycardia and atrial fibrillation. PMID: 25443231
    10. The minor allele of rs4454537 is significantly associated with low bone density at the total hip of southern Chinese people. Our study further suggests GREM2 as a novel susceptibility gene for osteoporosis. PMID: 23902946
    11. Through regulation of bone morphogenetic protein signaling, GREM2 is required for cardiac laterality and atrial differentiation during embryonic development. PMID: 23223679
    12. and that a genetic variant in the FMN2/GREM2 locus influences GREM2 expression in osteoblasts and thereby trabecular number and thickness as well as fracture risk. PMID: 23437003

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  • 相關(guān)疾病：
    Tooth agenesis, selective, 9 (STHAG9)
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    DAN family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17655

    OMIM: 608832

    KEGG: hsa:64388

    STRING: 9606.ENSP00000318650

    UniGene: Hs.98206