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  4. Human Hemoglobin subunit delta(HBD) ELISA kit

Human Hemoglobin subunit delta(HBD) ELISA kit

  • 中文名稱：
    人血紅蛋白δ亞基(HBD)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL010152HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人血紅蛋白δ亞基(HBD)酶聯(lián)免疫試劑盒（CSB-EL010152HU）為競爭法ELISA試劑盒，定量檢測血清、血漿、RBC裂解物.樣本中的HBD含量。試劑盒檢測范圍為0.007 ng/mL-30 ng/mL，本試劑盒通過特異性抗體捕獲樣本中的HBD分子，結(jié)合酶標反應(yīng)體系實現(xiàn)精準定量，適用于科研領(lǐng)域?qū)ρ合到y(tǒng)疾病模型的機制研究、紅細胞功能分析或相關(guān)生物標志物的體外檢測。實驗支持多種生物樣本類型，尤其針對紅細胞裂解液樣本可有效評估細胞內(nèi)HBD的表達動態(tài)。該產(chǎn)品為探索血紅蛋白亞基調(diào)控機制、藥物干預(yù)對紅細胞代謝的影響等基礎(chǔ)研究提供可靠工具，滿足實驗室對低豐度靶標的高靈敏度檢測需求。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Delta-globin ELISA Kit; HBD ELISA Kit; HBD_HUMAN ELISA Kit; Hemoglobin delta chain ELISA Kit; Hemoglobin subunit delta ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, lysate for RBC.
  • 檢測范圍：
    0.007 ng/mL-30 ng/mL
  • 靈敏度：
    0.007 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Competitive
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in oxygen transport from the lung to the various peripheral tissues.
  • 基因功能參考文獻：
    1. Blood donor homozygous for Hb D Los Angeles. PMID: 25217459
    2. The expression of the activated delta-globin gene in a beta-thalassemia mice model greatly improves the phenotype, validating the delta-globin chain as a therapeutic target for beta-hemoglobinopathies. PMID: 23872310
    3. Data indicate that a delta-globin mutation was suspected in both patients. PMID: 23806011
    4. Twenty-one different mutations were detected, and of these 12 have not been previously described. PMID: 23215833
    5. A functional promoter polymorphism of the delta-globin gene is a specific marker of the Arab-Indian haplotype PMID: 22641479
    6. This report describes a novel missense mutation in delta-globin (HBD: c.323G>A, Gly > Asp) in an Indian family with heterozygous beta-thalassemia with normal HbA(2) levels. PMID: 22477537
    7. The 5' breakapoint of the (deltabeta)(0) thalassemia deletion in a compound heterozygote was located in the second intron of the delta globin gene. PMID: 11860449
    8. Hb A2-Monreale [delta146(HC3)His-->Arg]is a novel delta chain variant. PMID: 11939506
    9. alternate mRNA species in adult erythroid cells; mRNA encodes an additional 145 nt in the upstream untranslated region, suggesting an alternative site of transcriptional initiation and transcription through the previously defined promoter PMID: 15234005
    10. The atomic coordinates of the delta-chain of hemoglobin A2 (R2 state) are used to model the structure of hemoglobin homotetramer delta 4, which occurs in rare hemoglobin H disease. PMID: 15449937
    11. Deletion pf this geneis a common, and possibly the predominant beta-thalassemia mutation of the Austroasiatic Lao Theung population. PMID: 15757827
    12. characterization of the delta-globin gene alleles and of RFLP-haplotypes, SNPs and one microsatellite associated with them in 231 carriers originating principally from East Sicily; Seventeen alleles were identified, of which five were new PMID: 18221842
    13. Borderline HbA(2) is not a rare event in a population with a high prevalence of beta-thalassemia carriers PMID: 18603555
    14. Unusually low levels of HBA2 in a compound heterozygote can be explained from the functional inhibition of the HBD gene, in cis to the HBG1 gene, bearing the nd-HPFH mutation. PMID: 18615450
    15. Hb A2 IVS-I-5 (G > C) beta-thalassemia mutation phenotype in 289 carriers was reported. PMID: 18932068

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  • 蛋白家族：
    Globin family
  • 組織特異性：
    Red blood cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4829

    OMIM: 142000

    KEGG: hsa:3045

    STRING: 9606.ENSP00000369654

    UniGene: Hs.699280