Human IL-1 Receptor Like 1(IL1RL1)ELISA Kit
-
中文名稱:人白介素1受體樣1(IL1RL1)酶聯(lián)免疫試劑盒
-
貨號(hào):CSB-E13789h
-
規(guī)格:96T/48T
-
價(jià)格:¥3600/¥2500
-
其他:
產(chǎn)品詳情
-
產(chǎn)品描述:人白介素1受體樣1(IL1RL1)酶聯(lián)免疫試劑盒(CSB-E13789h)為雙抗夾心法ELISA試劑盒,定量檢測(cè)血清、血漿、組織勻漿樣本中的IL1RL1含量。IL1RL1 是重要靶點(diǎn)。它在免疫調(diào)節(jié)中發(fā)揮關(guān)鍵作用,參與炎癥信號(hào)傳導(dǎo)等生理過(guò)程。研究聚焦其與疾病發(fā)生發(fā)展機(jī)制的關(guān)聯(lián),探索通過(guò)干預(yù) IL1RL1 信號(hào)通路,為相關(guān)炎癥性疾病、免疫疾病的治療提供新策略。試劑盒檢測(cè)范圍為0.312 ng/ml-20 ng/ml,靈敏度為0.078 ng/ml。適用于基礎(chǔ)科研中探究IL1RL1在炎癥反應(yīng)、心血管疾病模型或免疫調(diào)節(jié)機(jī)制中的動(dòng)態(tài)表達(dá)規(guī)律;適用于體外培養(yǎng)組織樣本、動(dòng)物模型血清或臨床前研究血漿中IL1RL1的濃度監(jiān)測(cè),為疾病機(jī)制研究及藥物靶點(diǎn)驗(yàn)證提供可靠工具本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書。
-
別名:DER-4 ELISA Kit; DER4 ELISA Kit; FIT 1 ELISA Kit; Growth stimulation expressed ELISA Kit; homolog of mouse growth stimulation-expressed ELISA Kit; Il1rl1 ELISA Kit; IL33R ELISA Kit; ILRL1_HUMAN ELISA Kit; Interleukin 1 receptor like 1 ELISA Kit; interleukin 1 receptor related protein ELISA Kit; Interleukin-1 receptor-like 1 ELISA Kit; Protein ST2 ELISA Kit; ST2 ELISA Kit; ST2L ELISA Kit; ST2V ELISA Kit; T1 ELISA Kit; T1 protein ELISA Kit
-
縮寫:
-
Uniprot No.:
-
種屬:Homo sapiens (Human)
-
樣本類型:serum, plasma, tissue homogenates
-
檢測(cè)范圍:0.312 ng/ml -20 ng/ml
-
靈敏度:0.078 ng/ml
-
反應(yīng)時(shí)間:1-5h
-
樣本體積:50-100ul
-
檢測(cè)波長(zhǎng):450 nm
-
研究領(lǐng)域:Others
-
測(cè)定原理:quantitative
-
測(cè)定方法:Sandwich
-
精密度:
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
-
線性度:
To assess the linearity of the assay, samples were spiked with high concentrations of human IL1RL1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
Sample
Serum(n=4)
1:1
Average %
92
Range %
89-97
1:2
Average %
94
Range %
90-102
1:4
Average %
92
Range %
87-99
1:8
Average %
95
Range %
89-98
-
回收率:
The recovery of human IL1RL1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample Type
Average % Recovery
Range
Serum (n=5)
96
92-99
EDTA plasma (n=4)
93
87-98
-
標(biāo)準(zhǔn)曲線:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ng/ml
OD1
OD2
Average
Corrected
20
2.693
2.719
2.706
2.547
10
2.155
2.167
2.161
2.002
5
1.439
1.421
1.430
1.271
2.5
0.907
0.898
0.903
0.744
1.25
0.558
0.547
0.553
0.394
0.625
0.373
0.375
0.374
0.215
0.312
0.284
0.28
0.282
0.123
0
0.161
0.157
0.159
-
數(shù)據(jù)處理:
-
貨期:3-5 working days
引用文獻(xiàn)
- Associations of MEFV gene variants, IL-33, and sST2 with the risk of Henoch-Sch?nlein purpura in children Y Ruan,Heliyon,2024
- The Interleukin-33/ST2 Axis Enhances Lung-Resident CD14+ Monocyte Function in Patients with Non-Small Cell Lung Cancer L Wang,Immunological Investigations,2022
- Prognostic value of plasma ST2 in patients with non-ST segment elevation acute coronary syndrome Kokkoz.et al,Turkish Journal of Emergency Medicine,2018
相關(guān)產(chǎn)品
相關(guān)問(wèn)答
靶點(diǎn)詳情
-
最新研究進(jìn)展:IL1RL1是一種受體蛋白,與IL-1家族的其他蛋白有關(guān)。研究表明,IL1RL1在免疫系統(tǒng)中具有重要作用,特別是在過(guò)敏性疾病中。最新的研究還發(fā)現(xiàn),IL1RL1可能與神經(jīng)退行性疾病如阿爾茨海默病有關(guān)。IL1RN是一種自然抑制劑,可調(diào)節(jié)IL-1家族蛋白的活性。最新研究表明,IL1RN在多種疾病中發(fā)揮重要作用,包括炎癥性腸病、自身免疫病和神經(jīng)退行性疾病等。此外,IL1RN在某些情況下也可能是一種潛在的治療靶點(diǎn)。
-
功能:Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.; Inhibits IL-33 signaling.
-
基因功能參考文獻(xiàn):
- Patients with heart failure and type 2 diabetes mellitus with AGT TT + MT genotype had a higher level of ST2 and a higher probability of unfavorable cardiovascular events during 24 months of observation compared with MM genotype carriers. PMID: 29578435
- IL33R was found induced in the blood of asthmatic children with additional gram-positive bacteria in the nasopharynx. PMID: 28262704
- Higher IL-33 and lower s-ST2 receptor baseline serum levels were detected in Pru p 3--sensitized allergic patients (SAP). IL-33/s-ST2 ratio is increased in Pru p 3-SAP and more in patients who experienced severe systemic symptoms. PMID: 29774370
- sST2 is downregulated in high-metastatic cells compared with low-metastatic human and mouse CRC cells. Knockdown of sST2 in low-metastatic cells enhances tumour growth, metastasis and tumour angiogenesis, whereas its overexpression in high-metastatic cells suppresses these processes. PMID: 27882929
- IL-33 promotes Renal Cell Carcinoma cell proliferation and chemotherapy resistance via its receptor ST2 and the JNK signaling activation in tumor cells. PMID: 29763892
- sST2 in preschool wheezers has predictive value for the development of eosinophilic airway inflammation in asthmatic children at school age. PMID: 28440062
- Findings indicate that IL33 may be involved in the process of glioma cell invasion and migration by upregulating MMP2 and MMP9 via the ST2-NF-kappaB signaling pathway. PMID: 28849217
- is involved in Th2 inflammation including eosinophil activation. Single nucleotide polymorphisms (SNPs) of the IL1RL1 gene are associated with asthma development and increased peripheral blood eosinophil counts. PMID: 29153414
- Findings indicate that IL-10 act as a negative regulator of IL-33/ST2 signaling pathways in vivo. PMID: 28415811
- Foxp3(+) cells in the brains of Multiple sclerosis patients predominantly produce interleukin-10 (IL-10) and show high expression of the IL-33 receptor ST2. PMID: 28169287
- In patients with stable mild to moderate chronic heart failure with reduced ventricular ejection fraction, a single measurement of sST2 protein and glucose were independent variables for hospitalization due to worsening CHF over a 1-year follow-up period. PMID: 29068593
- present study highlights significant associations between ST2 and inflammatory bowel disease. PMID: 27001944
- Data show that interleukin-2 receptor alpha, tumor necrosis factor receptor 1, serum STimulation-2 (IL1RL1 gene product), and regenerating islet-derived 3-alpha were significantly associated with non-relapse mortality. PMID: 28126963
- Serum IL-33 and sST2 levels, and CD4+ST2L+ expression in peripheral blood mononuclear cells are closely associated with HIV-1 infection and immune reconstitution in patients received highly-active antiretroviral therapy. PMID: 28466817
- Elevated levels of sST2 concentration in stable coronary heart disease patients may independently predict short- and long-term risk for fatal CVD events and total mortality but not non-fatal CVD events. PMID: 28283847
- Patients with severe aortic valve stenosis present elevated sST2 levels. Left ventricular global longitudinal strain resulted the only independent predictor of sST2 levels. PMID: 28664478
- The Il1RL1 rs950880 AA homozygote is an independent predictor of all-cause mortality in coronary artery disease and peripheral arterial disease patients. PMID: 28110258
- In a cohort of hypertensive heart failure subjects, soluble ST2 correlates significantly with indicators of right ventricular function. PMID: 28860791
- Data provide evidence that increased IL-33/ST2 levels in patients with chronic kidney disease are an indicator of increased inflammation, impaired endothelial functions, and cardiovascular events. PMID: 28614418
- Serum levels of IL33R were positively correlated with cognitive performance in patients with schizophrenia. PMID: 28126482
- Interleukin 1 receptor-like 1 (ST2/IL1RL1) is a biomarker for cardiac stress and heart failure, which can be associated with cocaine use. Data suggest that serum ST2/IL1RL1 levels are up-regulated by cocaine use; cocaine use appears to be associated with subclinical cardiac stress and damage outside of acute cardiac events; elevated serum ST2/IL1RL1 levels may serve as biomarkers for cocaine-induced cardiac complications. PMID: 28442257
- Preterm labor was associated with diminished expression of the alpha-chain of IL-33 receptor on choriodecidual B cells. PMID: 27918564
- Study found that macrophages expressed ST2L with a membrane pattern. The membrane pattern of ST2L was strongly expressed if the macrophages infiltrating the shoulder region of the plaque had an epithelioid aspect suggesting its possible role in the pathogenetic mechanisms of atherosclerotic lesions progression and rupture. PMID: 27223112
- The higher levels of IL-33 and its receptor ST2 in tissue and serum reflect an active inflammatory state and may represent a potential biomarker for disease activity. PMID: 26343805
- The genetic risk score for rs1041973 and rs16924161 demonstrated a higher risk for SPT positivity against B. tropicalis, the greater the number of risk alleles for both SNPs. Our findings demonstrate a robust association of genetic variants in IL1RL1 and IL33 SNPs with allergy markers and asthma. PMID: 28266165
- Increased sST2 and IL-10 but not IL-33 may be involved in the pathogenic process of IgAN. PMID: 27900334
- No significant differences in genotypic and allelic frequencies of thers13015714 in interleukin 1 receptor like 1 was observed between cases and controls and between mild/severe and early/late-onset Preeclampsia. PMID: 27023364
- IL-33 and ST2 are expressed in periapical granulomas and radicular cysts. PMID: 25677987
- An hyperexpression of soluble ST2 was found in Sjogren syndrome patients. PMID: 27097949
- ST2 is associated with advanced and metastatic disease in GC patients and significantly correlates with the duration of the disease. PMID: 26835712
- In patients with endometriosis, ST2 was positively associated with VAS score. PMID: 25069762
- rs1558641 was positively associated with atopic asthma in a Chinese population. PMID: 26493291
- two new polymorphisms in the distal promoter region of the ST2 gene that possibly influence susceptibility to severe coronary artery disease PMID: 20602249
- IL-33 and ST2 can be detected in lysates from both normal and pre-eclampsia placentas PMID: 21949719
- in an unselected cohort of patients admitted to the ICU, sST2 was an independent predictor of 90-day all-cause mortality PMID: 22155704
- The pro-T helper (Th)2 cell effects of mature IL-33 are due to differential utilization of the interleukin (IL)-33 receptor chain ST2, whereas their similar effects result from regulation of gene expression. PMID: 22634619
- Expression of IL-33 receptor ST2 in human adipose tissue is increased by severe obesity indicating an autocrine action. Thus, the adipose tissue microvasculature could participate in obesity-associated inflammation and related complications via IL-33/ST2. PMID: 22828942
- Elevated serum ST2 (and IL-33) were both associated with increased mortality in myocardial infarction patients. PMID: 22835988
- Serum soluble ST2 levels are increased in patients with pulmonary arterial hypertension. PMID: 23290950
- Soluble ST2 measurement provides diagnosis of stable heart failure in hypertensive patients. PMID: 23482076
- human cardiac and vascular cells have different distribution patterns of ST2 isoforms (sST2 and transmembrane ST2L) mRNA expression and produce different amounts of sST2 protein. PMID: 23567618
- A significant correlation was found between TNF-alpha and IL-33 mRNA expression in the asthmatic subjects. PMID: 23855553
- IL-33/sST2 may be involved in the pathogenesis of primary Sjogren's Syndrome (pSS) and partly contribute to the interstitial lung disease (ILD) in pSS patients. PMID: 23910012
- ST2 levels measured at the initiation of therapy for GVHD and during the first month after transplantation improved risk stratification for treatment-resistant GVHD and death without relapse after transplantation. PMID: 23924003
- Genetic variation in IL1RL1 can result in increased levels of ST2 and alter immune and inflammatory signaling through the ST2/IL-33 pathway. PMID: 23999434
- ST2 blood levels are higher in nonsurvivors than in surviving heart failure patients. PMID: 24239955
- Soluble ST2 serum levels improve long-term prediction in patients with renal insufficiency even more than in the total cohort. PMID: 24263122
- uPAR, IL-33, and ST2 values as a predictor of subclinical chorioamnionitis in preterm premature rupture of membranes. PMID: 24304137
- Serum ST2 levels were increased, and salivary gland expression was downregulated in patients with primary Sjogren's syndrome. PMID: 24385203
- increased sST2 was an independent predictor of long-term all-cause mortality PMID: 24401186
顯示更多
收起更多
-
亞細(xì)胞定位:[Isoform C]: Cell membrane.; [Isoform B]: Secreted.; Cell membrane; Single-pass type I membrane protein.
-
蛋白家族:Interleukin-1 receptor family
-
組織特異性:Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C
-
數(shù)據(jù)庫(kù)鏈接:
Most popular with customers
-
Human Transforming Growth factor β1,TGF-β1 ELISA kit
Detect Range: 23.5 pg/ml-1500 pg/ml
Sensitivity: 5.8 pg/ml
-
-
-
Mouse Tumor necrosis factor α,TNF-α ELISA Kit
Detect Range: 7.8 pg/ml-500 pg/ml
Sensitivity: 1.95 pg/ml
-
-
-
-