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  4. Human Ig alpha-1 chain C region(IGHA1) ELISA kit

Human Ig alpha-1 chain C region(IGHA1) ELISA kit

  • 中文名稱：
    人Ig α1鏈C區(qū)(IGHA1)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL011111HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人Ig α1鏈C區(qū)(IGHA1)酶聯(lián)免疫試劑盒（CSB-EL011111HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿樣本中的IGHA1含量。IGHA1作為靶點，在相關(guān)研究中有重要價值。它可能與特定生理病理機(jī)制有關(guān)，研究主要聚焦于其在疾病發(fā)生發(fā)展里的作用機(jī)制，探索以它為靶點開發(fā)針對性藥物或治療手段，有望為相關(guān)疾病的防治帶來新突破。試劑盒檢測范圍為0.49 ng/mL-2000 ng/mL，適用于免疫學(xué)基礎(chǔ)研究、黏膜相關(guān)疾病機(jī)制探索（如感染性疾病或過敏模型）、免疫缺陷評估等科研領(lǐng)域。實驗樣本兼容常規(guī)生物液體樣本類型，尤其適合評估體液免疫應(yīng)答動態(tài)或特定病理條件下IgA抗體的表達(dá)特征，為研究黏膜免疫調(diào)控、宿主 - 病原體互作等課題提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    IGHA1 ELISA Kit; Immunoglobulin heavy constant alpha 1 ELISA Kit; Ig alpha-1 chain C region ELISA Kit; Ig alpha-1 chain C region BUR ELISA Kit; Ig alpha-1 chain C region TRO ELISA Kit
  • 縮寫：
    IGHA1
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma
  • 檢測范圍：
    0.49 ng/mL-2000 ng/mL
  • 靈敏度：
    0.49 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human IGHA1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:5000 Average % 92    
    Range % 85-103    
    1:10000 Average % 91    
    Range % 85-99    
    1:20000 Average % 97    
    Range % 90-108    
    1:40000 Average % 92    
    Range % 83-100    
  • 回收率：
    The recovery of human IGHA1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 95 83-101    
    EDTA plasma (n=4) 95 90-100    
                   
                   
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    ng/ml OD1 OD2 Average Corrected    
    2000 2.234 2.285 2.260 2.171    
    500 2.112 2.165 2.139 2.050    
    125 1.886 1.897 1.892 1.803    
    31.25 1.265 1.245 1.255 1.166    
    7.81 0.608 0.587 0.598 0.509    
    1.95 0.290 0.286 0.288 0.199    
    0.49 0.136 0.139 0.138 0.049    
    0 0.086 0.091 0.089 　    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. Ig alpha is the major immunoglobulin class in body secretions.
  • 相關(guān)疾病：
    A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.
  • 亞細(xì)胞定位：
    Secreted. Cell membrane.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5478

    OMIM: 146900

    UniGene: Hs.699841