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  4. Human Integrin beta-8(ITGB8) ELISA kit

Human Integrin beta-8(ITGB8) ELISA kit

  • 中文名稱：
    人整合素β-8(ITGB8)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL011892HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人整合素β-8(ITGB8)酶聯(lián)免疫試劑盒（CSB-EL011892HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿,組織勻漿樣本中的ITGB8含量。ITGB8是一種靶點。它在細胞黏附、信號傳導等生理過程中發(fā)揮作用。研究機制方面，其可能與腫瘤、神經(jīng)系統(tǒng)疾病等發(fā)病機制相關，通過與配體結合影響細胞行為，目前正開展深入研究以探尋其在疾病治療中的潛在價值。試劑盒檢測范圍為0.39 ng/mL-25 ng/mL，適用于細胞生物學、腫瘤微環(huán)境研究、血管生成機制探索等科研領域，可幫助研究者定量分析不同生理或病理條件下ITGB8的表達水平變化。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    ITGB8; Integrin beta-8
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測范圍：
    0.39 ng/mL-25 ng/mL
  • 靈敏度：
    0.09 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

相關問答

■ 常見問題解答
Q:

Could you please confirm for me whether the standard used in your kit for human ITG8 is just the beta 8 subunit or it is a heterodimer with alpha subunit?
Normally integrin 8 exists as a heterodimer with alpha v subunit and wanted to check whether the standard in your kit contains just b8?

A:
Thanks for your inquiry!The standatd of csb-el011892hu is 293 cell-derived recombinant human Integrin beta-8 protein)(contains just b8).

靶點詳情

  • 功能：
    Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis.
  • 基因功能參考文獻：
    1. ITGB8 is identified as a novel target of miR-26a-5p. PMID: 29746867
    2. our results indicate that miR-199a-3p enhances cisplatinsensitivity of ovarian cancer cells through downregulating ITGB8 expression, and miR-199a-3p may serve as a therapeutic target for the treatment of ovarian cancer patients with cisplatin-resistance. PMID: 29436681
    3. In cellular model, the microRNA-513a-3p was identified as a novel element targeting ITG-beta8, thereby controlling the protein level and its molecular function in the controlling of migration and pro-inflammatory environment. PMID: 29204818
    4. Among Greek and Polish patients with intracerebral hemorrhage, heterozygous individuals with the rs10251386 and the rs10239099 of the ITGB8 gene had significantly lower age of ICH onset compared to the wild-type genotypes. PMID: 27476161
    5. The results demonstrated that the hsa_circ_0046701/miR-142-3p/ITGB8 axis might play critical regulatory roles in the pathogenesis and development of glioma. PMID: 29337055
    6. Integrin beta8 was differentially expressed between Fibromyalgia patients and healthy controls. PMID: 27157394
    7. Integrin Beta8 plays a role in the motility of prostate cancer cells. PMID: 25886373
    8. data show that integrin beta 8, but not integrin beta 5 or integrin beta 6, protein expression is increased in liver specimens of patients with biliary atresia PMID: 25079481
    9. Brain metastases ITGB8 expression exhibits considerable heterogeneity according to tumor origin. PMID: 24294359
    10. Desmoglein-2 co-localizes with integrin-beta8 in N-MVECs. PMID: 23874518
    11. ITGB8 silencing may change lung cancer cells to a less invasive phenotype through alteration in the expression of metastasis-related genes. PMID: 22753015
    12. Deletion of the Itgb8 gene from retinal ganglia cells and Mu ller glia, but not astrocytes, results in highly abnormal vascular patterning and instability. PMID: 22279205
    13. Highly angiogenic and poorly invasive glioblastomas expressed low levels of beta8 integrin, whereas highly invasive glioblastomas with limited neovascularization expressed high levels of beta8 integrin. PMID: 21859829
    14. Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture. PMID: 21878622
    15. miR-93 promotes the growth of, and angiogenesis in astrocytomas, by suppressing, at least in part, integrin-beta8 expression. PMID: 20956944
    16. Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway PMID: 20519498

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Integrin beta chain family
  • 組織特異性：
    Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6163

    OMIM: 604160

    KEGG: hsa:3696

    STRING: 9606.ENSP00000222573

    UniGene: Hs.592171