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  4. Human Inter-alpha-trypsin inhibitor heavy chain H5(ITIH5) ELISA kit

Human Inter-alpha-trypsin inhibitor heavy chain H5(ITIH5) ELISA kit

  • 中文名稱：
    人間α-胰蛋白酶抑制劑重鏈H5(ITIH5)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL011898HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人間α-胰蛋白酶抑制劑重鏈H5(ITIH5)酶聯(lián)免疫試劑盒（CSB-EL011898HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的ITIH5含量。人間α-胰蛋白酶抑制劑重鏈H5（ITIH5）是一種細(xì)胞外基質(zhì)蛋白，與缺血性心肌?。↖CM）和慢性腎病相關(guān)。研究發(fā)現(xiàn)，ITIH5可作為ICM的診斷標(biāo)記物，并在心肌梗死后促進(jìn)纖維化重塑，其作用機(jī)制涉及調(diào)節(jié)細(xì)胞外基質(zhì)、巨噬細(xì)胞和成纖維細(xì)胞之間的相互作用。試劑盒檢測(cè)范圍為1.56 ng/mL-100 ng/mL，該產(chǎn)品支持科研人員探究 ITIH5 在疾病模型中的表達(dá)調(diào)控機(jī)制，如分析其在腫瘤微環(huán)境、慢性炎癥或纖維化疾病中的生物學(xué)功能，也可用于評(píng)估藥物干預(yù)或基因編輯對(duì) ITIH5 表達(dá)水平的影響，為分子病理學(xué)、轉(zhuǎn)化醫(yī)學(xué)及蛋白功能研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    ITIH5 ELISA Kit; KIAA1953 ELISA Kit; PP14776 ELISA Kit; UNQ311/PRO354 ELISA Kit; Inter-alpha-trypsin inhibitor heavy chain H5 ELISA Kit; ITI heavy chain H5 ELISA Kit; ITI-HC5 ELISA Kit; Inter-alpha-inhibitor heavy chain 5 ELISA Kit
  • 縮寫：
    ITIH5
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    1.56 ng/mL-100 ng/mL
  • 靈敏度：
    0.39 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Cell Biology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May act as a tumor suppressor.
  • 基因功能參考文獻(xiàn)：
    1. ITIH5 may represent a novel modulator of TGF-beta superfamily signaling. PMID: 28940371
    2. Results provide evidence that ITIH5 triggers a reprogramming of breast cancer cells through global epigenetic changes effecting DAPK1. ITIH5 may represent an ECM modulator in epithelial breast tissue mediating suppression of tumor initiating cancer cell characteristics which are thought being responsible for the metastasis of breast cancer. PMID: 28231808
    3. Low ITIH5 expression is associated with liver metastasis in pancreatic cancer. PMID: 28289921
    4. This is the first study so far showing a putative tumor suppressive function of ITIH5 in cervical carcinogenesis. PMID: 28059468
    5. The current study describes a novel mechanism linking the TSG-6 transfer of the newly described HC5 to the HA-dependent control of cell phenotype. The interaction of HC5 with cell surface HA was essential for TGFbeta1-dependent differentiation of fibroblasts to myofibroblasts, highlighting its importance as a novel potential therapeutic target. PMID: 27143355
    6. ITIH5 may be a novel putative tumor suppressor gene in NSCLC with a potential molecular significance in the squamoid ADC subtype and further clinical impact for risk stratification of adenocarcinoma patients. PMID: 26252352
    7. Hence, we can strengthen the presumption that ITIH5 may constitute a novel regulatory molecule of the human skin that could play an important role in in fl ammation via its interaction with hyaluronic acid. PMID: 25809190
    8. ITIH5 expression is decreased in gastric cancer and that low expression of this protein is associated with poor clinical outcome. PMID: 24913813
    9. ITIH5 is a novel putative tumor suppressor gene in colon cancer with a potential impact in the CIMP-related pathway. PMID: 25093535
    10. Tumor-specific methylation of the three-gene panel (ITIH5, DKK3, and RASSF1A) might be a valuable biomarker for the early detection of breast cancer. PMID: 23320751
    11. provide evidence that down-regulation of ITIH5 by aberrant DNA hypermethylation may provoke invasive phenotypes in human bladder cancer PMID: 24265292
    12. ITIH5 gene expression is regulated both by obesity and by the region between visceral and subcutaneous adipose tissue. PMID: 22616691
    13. ITIH-5 is highly expressed in sc adipose tissue, increased in obesity, down regulated after weight loss, and associated with measures of body size and metabolism. PMID: 21852814
    14. expression is consistantly lost or strongly downregulated in invasive ductal carcinoma; proposed that loss of ITIH5 expression may be involved in breast cancer development PMID: 14744536
    15. Promoter methylation-mediated loss of ITIH5 expression is associated with unfavourable outcome in breast cancer patients. PMID: 17653090
    16. Both ITIH5 protein expression and ITIH5 promoter methylation may serve as prognostic biomarkers, thereby helping improve clinical patient outcome. PMID: 18810445

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    ITIH family
  • 組織特異性：
    Abundantly expressed in placenta. Less abundant expression in mammary gland and ovary. Expression is barely detectable levels in all other tissues tested.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21449

    OMIM: 609783

    KEGG: hsa:80760

    STRING: 9606.ENSP00000256861

    UniGene: Hs.498586