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  4. Human Interferon alpha/beta receptor 2(IFNAR2) ELISA kit

Human Interferon alpha/beta receptor 2(IFNAR2) ELISA kit

  • 中文名稱：
    人干擾素α/β受體2(IFNAR2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL011047HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人干擾素α/β受體2(IFNAR2)酶聯(lián)免疫試劑盒（CSB-EL011047HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的IFNAR2含量。IFNAR2是Ⅰ型干擾素受體的亞基之一。它在機(jī)體免疫系統(tǒng)中發(fā)揮重要作用，能與干擾素結(jié)合觸發(fā)細(xì)胞內(nèi)信號(hào)傳導(dǎo)通路。研究其機(jī)制有助于理解抗病毒、抗腫瘤等免疫反應(yīng)過程，也為開發(fā)靶向治療藥物，干預(yù)相關(guān)疾病進(jìn)程提供依據(jù)。試劑盒檢測(cè)范圍為31.25 pg/ml- 2000pg/ml，基礎(chǔ)研究中IFNAR2蛋白表達(dá)動(dòng)力學(xué)分析、疾病模型機(jī)制探索、藥物干預(yù)效果評(píng)估、研究干擾素信號(hào)通路調(diào)控及免疫相關(guān)疾病機(jī)制本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Human interferon alpha/beta receptor ELISA Kit; IFN alpha REC ELISA Kit; IFN R ELISA Kit; IFN-alpha binding protein ELISA Kit; IFN-alpha/beta receptor 2 ELISA Kit; IFN-R-2 ELISA Kit; IFNABR ELISA Kit; IFNAR2 ELISA Kit; IFNARB ELISA Kit; IFNR ELISA Kit; INAR2_HUMAN ELISA Kit; Interferon (alpha beta and omega) receptor 2 ELISA Kit; Interferon alpha binding protein ELISA Kit; Interferon alpha/beta receptor 2 ELISA Kit; Interferon alpha/beta receptor beta chain ELISA Kit; Type I interferon receptor 2 ELISA Kit; Type I interferon receptor ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    31.25 pg/ml - 2000pg/ml
  • 靈敏度：
    7.8 pg/ml
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 線性度：
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway. Directly involved in signal transduction through its association with the TYR kinase JAK1. Involved in interferon-mediated STAT1, STAT2 and STAT3 activation.; Potent inhibitor of type I IFN receptor activity.
  • 基因功能參考文獻(xiàn)：
    1. The findings underline the roles of UL36USP-IFNAR2 interaction in counteracting the type I IFN-mediated signaling pathway and reveal a novel evasion mechanism of antiviral innate immunity by HSV-1. PMID: 29997210
    2. Report lowered serum IFNAR2 levels in multiple sclerosis patients are elevated on treatment with interferon-beta. PMID: 27613121
    3. this study shows that the surface expression levels of the common IFN-alpha/beta receptor subunit 2 are significantly higher on plasmacytoid dendritic cells from females in comparison to males PMID: 27891600
    4. A very small percentage of the pancreatic tumors showed strong expression of the IFNAR-2c. PMID: 25072284
    5. Lack of expression of functional IFNAR2 does not seem to be the major cause of interferon resistance in hepatitis C virus patients receiving standard interferon therapy. PMID: 26176069
    6. The effects of two functional polymorphisms, type I interferon receptor 2 gene (IFNAR2)-F8S and interleukin-10 receptor subunit beta gene (IL10RB)-K47E, on chronic hepatitis B virus (HBV) infection, were investigated. PMID: 23745570
    7. IFNAR2 overexpression was observed in various histological types of lung cancer, and appears to be associated with lung cancers that behave aggressively. PMID: 22236545
    8. In this study we have characterized the Stat2-IFNaR2 interaction and examined its role in IFNalpha signaling PMID: 11786546
    9. STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c PMID: 12105218
    10. Expression and signaling activity of interferon alpha/beta receptors modulates dendritic cell (DC) responsiveness during terminal maturation and differentiation of monocyte-derived DCs. PMID: 12218119
    11. Subunit 2 of the interferon alpha receptor (IFNaR2) is bound more avidly to Stat2 than is phosphorylated IFNaR1. PMID: 12220192
    12. Administration as a complex with sIFNAR-2 may provide a method of enhancing the delivery and effectiveness of type I interferons in Burkitt lymphoma in scid mice. PMID: 14980076
    13. IFNaR2, a subunit of the type I IFN receptor, is proteolytically cleaved in a regulated manner. PMID: 15286706
    14. Dynamics of the IFNAR2 extracellular domain binding site reveal highly flexible loop segments and a malleable binding surface interacting with the IFN ligand supported by a more rigid scaffold which stabilizes the binding site conformation. PMID: 15287740
    15. A dynamic model for the IFN-alpha/receptor complex predicts that IFNAR2 and IFNAR1 are probably anchored in close proximity on the cell surface and that upon IFN binding, the complex assumes a closed form, resulting in activation of intracellular kinases. PMID: 15449939
    16. IFNaR2 intracellular domain transcriptional modulation is dependent upon the carboxyl-terminal transactivation domain of Stat2. PMID: 15717316
    17. Rapid inhibition of MAPK signaling and anti-proliferation effect via JAK/STAT signaling by interferon-alpha in hepatocellular carcinoma cell lines. PMID: 16054712
    18. Oveexpression of IFNAR2 is associated with hepatocellular carcinoma PMID: 16106266
    19. Hepatic IFNAR2c mRNA expression appears to correlate inversely with the fibrosis stage and age in hepatitis C infection. PMID: 16518956
    20. Monocyte-derived dendritic cells can modulate their sensitivity to two IFN subtypes by differential regulation of the IFNAR subunits. PMID: 16624932
    21. IFNAR2 cytoplasmic domain serves to link STAT4 to the IFNAR as a pre-assembled complex that facilitates cytokine-driven STAT4 activation. PMID: 17095088
    22. binding of IFN-alpha8 rather than binding of IFN-alpha2 to IFNAR-2 leads to activation and subsequent antiproliferative activity despite the same antiviral activity in renal cell carcinoma PMID: 17572016
    23. The intensity and distribution of IFNAR-2 may predict the response to therapy with IFN-alpha and IFN-beta in pancreatic cancer. PMID: 17667505
    24. High IFNAR2 is associated with renal cell carcinoma metastasis PMID: 17697365
    25. Results demonstrated that FNAR2-extracellular domain interact differentially with two individual IFN-alphas, suggesting the mutual interaction between multiple IFN-alpha subtypes during the competition for binding to the receptor. PMID: 18027911
    26. The data suggest that liberation of the IFNaR2-ICD by regulated proteolysis could trigger a novel mechanism for moving the transcription factor Stat2 to the nucleus. PMID: 18456457
    27. The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor PMID: 18456658
    28. Findings show that interferon-alpha/beta receptor (IFNAR)-2 isoforms are important regulators of the responsiveness to endogenous and systemically administered interferon beta (IFNbeta). PMID: 18971450
    29. Results suggest that zinc, especially polaprezinc, enhances the expression of type 1 interferon 2 receptor in U937 cells, thereby inducing production of the anti-viral protein 2'-5'OAS. PMID: 19362011
    30. Ep-CAM is a potentially useful marker for resistance to INFalpha/5-FU therapy, especially in IFNAR2-positive cases. PMID: 19401692
    31. The IFNAR2-8SS genotype was associated with HBeAg negative patients; IFNAR2-8F allele was associated with the risk to high viral loads; the IFNAR2-8FF genotype predisposed to higher MxA gene induction and correlated with sustained IFN response. PMID: 19714778

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  • 相關(guān)疾病：
    Immunodeficiency 45 (IMD45)
  • 亞細(xì)胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
  • 蛋白家族：
    Type II cytokine receptor family
  • 組織特異性：
    Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5433

    OMIM: 602376

    KEGG: hsa:3455

    STRING: 9606.ENSP00000343957

    UniGene: Hs.708195