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  4. Human Interleukin-36 beta(IL1F8) ELISA kit

Human Interleukin-36 beta(IL1F8) ELISA kit

  • 中文名稱：
    人白介素36β(IL1F8)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL011619HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人白介素36β(IL1F8)酶聯(lián)免疫試劑盒（CSB-EL011619HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的IL1F8含量。IL1F8屬于IL-1家族成員。其背景在于在免疫調(diào)節(jié)等生理過程有潛在作用。研究機制方面，主要聚焦于它在細胞信號傳導路徑中的角色，可能通過與相應(yīng)受體結(jié)合調(diào)控免疫細胞功能，影響炎癥反應(yīng)等，是免疫學研究的潛在靶點。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL，適用于體外檢測不同來源樣本中IL - 36β的表達水平，為研究炎癥性疾病機制、藥物篩選或免疫調(diào)控實驗提供可靠工具；廣泛應(yīng)用于基礎(chǔ)科研領(lǐng)域，例如銀屑病動物模型研究、炎癥因子網(wǎng)絡(luò)分析或免疫治療相關(guān)細胞實驗，為探索IL - 36β在疾病微環(huán)境中的功能及潛在干預靶點提供技術(shù)支持本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    2310043N20Rik ELISA Kit; Family of interleukin 1 eta ELISA Kit; FIL1 (ETA) ELISA Kit; FIL1 ELISA Kit; FIL1 eta ELISA Kit; FIL1H ELISA Kit; FILI-(ETA) ELISA Kit; IL 1F8 (FIL1 eta ELISA Kit; IL 1F8 ELISA Kit; IL 1H2 ELISA Kit; IL-1 eta ELISA Kit; IL-1F8 ELISA Kit; IL-1H2 ELISA Kit; IL1 ETA ELISA Kit; IL1F8 (Canonical product IL 1F8a) ELISA Kit; IL1F8 ELISA Kit; IL1F8_HUMAN ELISA Kit; IL1H2 ELISA Kit; IL36 beta ELISA Kit; IL36B ELISA Kit; Interleukin 1 family, member 8 (eta) ELISA Kit; Interleukin 1 family, member 8 ELISA Kit; Interleukin 1 homolog 2 ELISA Kit; Interleukin 1 Superfamily e ELISA Kit; Interleukin 36 beta ELISA Kit; Interleukin-1 eta ELISA Kit; Interleukin-1 family member 8 ELISA Kit; Interleukin-1 homolog 2 ELISA Kit; MGC126880 ELISA Kit; MGC126882 ELISA Kit; OTTMUSP00000012797 ELISA Kit; RP23-176J12.1 ELISA Kit
  • 縮寫：
    IL1F8
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍：
    15.6 pg/mL-1000 pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human IL1F8 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:1 Average % 88  
    Range % 84-92  
    1:2 Average % 96  
    Range % 90-102  
    1:4 Average % 89  
    Range % 85-94  
    1:8 Average % 88  
    Range % 84-95  
  • 回收率：
    The recovery of human IL1F8 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 86 80-92  
    EDTA plasma (n=4) 100 96-104  
                 
                 
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected  
    1000 2.537 2.598 2.568 2.404  
    500 2.062 2.091 2.077 1.913  
    250 1.399 1.368 1.384 1.220  
    125 0.799 0.771 0.785 0.621  
    62.5 0.555 0.534 0.545 0.381  
    31.2 0.374 0.395 0.385 0.221  
    15.6 0.271 0.294 0.283 0.119  
    0 0.163 0.165 0.164 　  
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.
  • 基因功能參考文獻：
    1. IL-36-mediated IL-6 and CXCL8 production in human lung fibroblasts and bronchial epithelial cells may be involved in pulmonary inflammation especially caused by bacterial or viral infections. PMID: 28869889
    2. With a focus on the skin as a target for microbial and viral invasion, the current knowledge of IL-36: IL-36alpha, IL-36beta and IL-36gamma, functions is reviewed. One physiological function of the IL-36smay be to counteract microbial immune evasion. [Review] PMID: 28811383
    3. IL36B expression is induced in keratinocytes by Toll-like receptor ligands suggesting a function in barrier immune defense. PMID: 22318382
    4. IL-1F8 functions as an inducer of antimicrobial peptide and matrix metalloproteinase expression by keratinocytes; IL-1F8 is overexpressed in transgenic psoriatic model mouse skin. PMID: 21242515
    5. IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells PMID: 14734551
    6. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in samples from patients with rheumatoid arthritis PMID: 16646978

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  • 亞細胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    IL-1 family
  • 組織特異性：
    Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15564

    OMIM: 605508

    KEGG: hsa:27177

    STRING: 9606.ENSP00000259213

    UniGene: Hs.278909