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  4. Human Interleukin17C (IL17C) ELISA Kit

Human Interleukin17C (IL17C) ELISA Kit

  • 中文名稱：
    人白介素17C (IL17C)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E15917h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人白介素17C (IL17C)酶聯(lián)免疫試劑盒（CSB-E15917h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IL17C含量。IL17C是一個靶點。它屬于IL-17細胞因子家族，在感染免疫、炎性疾病發(fā)生發(fā)展中有重要作用。研究機制上，其能與受體結(jié)合激活下游信號通路，介導(dǎo)免疫反應(yīng)，目前在自身免疫病、腫瘤等領(lǐng)域是研究熱點。試劑盒檢測范圍為0.156 ng/ml-10 ng/ml，靈敏度為0.039 ng/ml。支持科研領(lǐng)域?qū)L17C在炎癥模型、免疫調(diào)控研究中的動態(tài)表達分析，或用于評估藥物干預(yù)對IL17C通路的影響；適用于細胞實驗、動物模型及臨床前研究中的生物標志物定量需求；為免疫相關(guān)疾病機制探索提供可靠工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    CX2 ELISA Kit; Cytokine CX2 ELISA Kit; IL 17C ELISA Kit; IL 21 ELISA Kit; IL-17C ELISA Kit; IL17C ELISA Kit; IL17C_HUMAN ELISA Kit; Interleukin 17C ELISA Kit; Interleukin-17C ELISA Kit; MGC126884 ELISA Kit; MGC138401 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.156 ng/ml -10 ng/ml
  • 靈敏度：
    0.039 ng/ml
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of human IL17C in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    88

    Range %

    83-97

    1:2

    Average %

    97

    Range %

    91-104

    1:4

    Average %

    84

    Range %

    81-88

    1:8

    Average %

    89

    Range %

    81-96

  • 回收率：

    The recovery of human IL17Cspiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    98

    94-101

    EDTA plasma (n=4)

    101

    98-106

  • 標準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    10

    1.784

    1.844

    1.814

    1.638

    5

    1.021

    1.029

    1.025

    0.849

    2.5

    0.674

    0.665

    0.670

    0.494

    1.25

    0.417

    0.416

    0.417

    0.241

    0.625

    0.288

    0.276

    0.282

    0.106

    0.312

    0.263

    0.242

    0.253

    0.077

    0.156

    0.232

    0.214

    0.223

    0.047

    0

    0.174

    0.178

    0.176

    　

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
  • 基因功能參考文獻：
    1. Inflammatory cell expression of IL-9 and IL-17C were increased in chronic rhinosinusitis, particularly with allergy and asthma. These interleukins may contribute to the pathogenesis of chronic rhinosinusitis with nasal polyps as well as atopy and may serve as therapeutic targets for disease management PMID: 26989880
    2. Helicobacter pylori infection was associated with a significant increase in IL-17C expression in gastric mucosa. The role of IL-17C in the pathogenesis of H. pylori-induced diseases remains to be determined. PMID: 28739826
    3. Data indicate that epithelial IL-17C promotes neutrophilic inflammation in the tumor microenvironment and suggest that IL-17C links a pathologic microbiota, as present in COPD patients, with enhanced tumor growth. PMID: 28346430
    4. CpG methylation is reduced in gingival biopsies of patients with periodontitis PMID: 26472015
    5. Those carrying rs3748067 CC genotype and C allele had a significantly increased risk for the development of gastric cancer PMID: 25012243
    6. IL-17C is an essential epithelial cell-derived cytokine. PMID: 23944933
    7. Our study provides evidence that Staphylococcus aureus activates NOD2 in keratinocytes, resulting in an increased expression of IL-17C, a mechanism that may be dysregulated in atopic dermatitis. PMID: 23892590
    8. Interleukin-17C is present in the tissue around aseptic loosened implants. PMID: 23474800
    9. IL-17C is involved in the innate immune response of respiratory epithelial cells and is suppressed by cigarette smoke. PMID: 23221046
    10. Data suggest that activation of TLR5 upregulates IL17C expression in cells from intestinal mucosa and colonic adenocarcinoma; IL17C expression is upregulated in intestinal mucosa cells from patients with ulcerative colitis compared with normal cells. PMID: 22994872
    11. Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation. PMID: 23359500
    12. In our pilot study, we discovered significant changes in methylation patterns of genes IL-7, IL-13, IL-17C and TYK2 between henodialysis patients and healthy subjects PMID: 22506826
    13. IL-17C is an essential autocrine cytokine that regulates innate epithelial immune responses. PMID: 21993848
    14. activation of NF-kappaB (p65/p50) is crucial for the TNFalpha-induced stimulation of IL-17C expression in human keratinocytes PMID: 21628458
    15. expressed in multiple sclerosis brain lesions PMID: 11984595

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    IL-17 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5983

    OMIM: 604628

    KEGG: hsa:27189

    STRING: 9606.ENSP00000244241

    UniGene: Hs.278911