Human Long palate, lung and nasal epithelium carcinoma-associated protein 4(C20orf186) ELISA kit

產(chǎn)品詳情

文獻(xiàn)引用 (3) 說明書下載

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.

產(chǎn)品描述：

人腭/肺/鼻上皮癌關(guān)聯(lián)蛋白4(C20orf186)酶聯(lián)免疫試劑盒（CSB-EL003694HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的C20orf186含量。試劑盒檢測范圍為25 pg/mL-1600 pg/mL，該產(chǎn)品可應(yīng)用于基礎(chǔ)科研領(lǐng)域，如探究C20orf186在鼻咽癌、肺癌等上皮源性腫瘤中的表達(dá)特征，評估其作為潛在生物標(biāo)志物的相關(guān)性，或用于藥物干預(yù)實驗中靶蛋白水平變化的動態(tài)監(jiān)測，為腫瘤發(fā)生機(jī)制研究及治療策略開發(fā)提供實驗支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
別名：

BPI fold-containing family B member 4 ELISA Kit; Bpifb4 ELISA Kit; C20orf186 ELISA Kit; dJ726C3.5 ELISA Kit; Gm1006 ELISA Kit; Ligand-binding protein RY2G5 ELISA Kit; Long palate; lung and nasal epithelium carcinoma-associated protein 4 ELISA Kit; LPLC4_HUMAN ELISA Kit; Lplunc4 ELISA Kit
縮寫：

C20orf186
Uniprot No.：

P59827
種屬：

Homo sapiens (Human)
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

25 pg/mL-1600 pg/mL
靈敏度：

6.25 pg/mL
反應(yīng)時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領(lǐng)域：

Neuroscience
測定原理：

quantitative
測定方法：

Sandwich

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of human C20orf186 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:1	Average %	93
	Range %	86-97
1:2	Average %	98
	Range %	92-106
1:4	Average %	84
	Range %	81-89
1:8	Average %	91
	Range %	83-98

回收率：

The recovery of human C20orf186 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	101	96-105
EDTA plasma (n=4)	93	88-99

標(biāo)準(zhǔn)曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

功能：

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received.
基因功能參考文獻(xiàn)：
1. LAV-BPIFB4 isoform modulates eNOS signalling through Ca2+/PKC-alpha-dependent mechanism. PMID: 28419216
2. In conclusion, BPIFB4 and CXCR4 expression classify long-lived individuals health status that correlates with maintained mononuclear cell migration. PMID: 28121621
3. Longevity-associated variant-BPIFB4 may represent a novel therapeutic tool to fight endothelial dysfunction and promote vascular reparative processes. PMID: 26034043
亞細(xì)胞定位：

Secreted. Cytoplasm.
蛋白家族：

BPI/LBP/Plunc superfamily, BPI/LBP family
組織特異性：

Expressed in nasal tissue.
數(shù)據(jù)庫鏈接：

HGNC: 16179

OMIM: 615718

KEGG: hsa:149954

STRING: 9606.ENSP00000364632

UniGene: Hs.38961