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  4. Human Loricrin(LOR) ELISA kit

Human Loricrin(LOR) ELISA kit

  • 中文名稱：
    人兜甲蛋白(LOR)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL013037HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人兜甲蛋白(LOR)酶聯(lián)免疫試劑盒（CSB-EL013037HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的LOR含量。試劑盒檢測范圍為25 pg/mL-1600 pg/mL，適用于科研場景中皮膚生物學機制研究、疾病模型表皮分化評估或藥物干預效果分析。科研人員可通過本產(chǎn)品定量檢測不同實驗條件下LOR的表達水平變化，為探索皮膚屏障功能調控、表皮異常分化機制及相關疾病發(fā)病機理提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    LOR ELISA Kit; LOR protein ELISA Kit; LORI_HUMAN ELISA Kit; Loricrin ELISA Kit; LRN ELISA Kit; MGC111513 ELISA Kit; OTTHUMP00000015823 ELISA Kit
  • 縮寫：
    LOR
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    25 pg/mL-1600 pg/mL
  • 靈敏度：
    6.25 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human LOR in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:1 Average % 85  
    Range % 81-89  
    1:2 Average % 97  
    Range % 94-100  
    1:4 Average % 98  
    Range % 95-101  
    1:8 Average % 87  
    Range % 82-91  
  • 回收率：
    The recovery of human LOR spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 93 90-96  
    EDTA plasma (n=4) 102 98-106  
                 
                 
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected  
    1600 2.424 2.468 2.446 2.300  
    800 1.561 1.598 1.580 1.434  
    400 0.986 0.946 0.966 0.820  
    200 0.634 0.657 0.646 0.500  
    100 0.411 0.435 0.423 0.277  
    50 0.295 0.275 0.285 0.139  
    25 0.202 0.213 0.208 0.062  
    0 0.145 0.147 0.146    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Major keratinocyte cell envelope protein.
  • 基因功能參考文獻：
    1. Authors report a multi-generation family with prominent ichthyosis and palmoplantar involvement due to a novel mutation in loricrin. PMID: 25965869
    2. Letter: Knockdown of either filaggrin or loricrin increases the productions of interleukin (IL)-1alpha, IL-8, IL-18 and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes. PMID: 26381575
    3. Studies on human keratinocytes recognized that loricrin expression was inversely related to the expression of the cyclin-dependent kinase inhibitor p21 PMID: 25896246
    4. two novel heterozygous frameshift mutations in exon 2 - c.646_647insGCAGCAGGTC, p.Gln216Argfs*123 and c.798_799dupT, p.Gly267Trpfs*69 in loricrin keratoderma patients PMID: 25234742
    5. Results describe a novel frameshift mutation leading to loricrin keratoderma presenting with colloidion membrane PMID: 25142840
    6. We found no mutations of Loricrin in two Progressive symmetrical erythrokeratoderma families. PMID: 23678955
    7. We describe a young man who was a collodion baby and had the typical presentation of Loricrin keratoderma. Direct DNA sequencing identified a heterozygous mutation in the loricrin gene with a single G insertion, 730insG, present in (a) the patient PMID: 22831754
    8. There were no mutations found in the LOR gene and the true pathogenesis of progressive symmetrical erythrokeratodermia remains unknown. PMID: 21198793
    9. These findings suggest that inverse effects of PKCdelta and PKCeta on loricrin expression attributes to the expression of c-Jun and JunD. PMID: 20184865
    10. regulation of gene expression requires interactions among multiple transcription factors in keratinocytes located in different compartments of the epidermis PMID: 12200429
    11. Unique mutations in glycine-rich domain of mutant loricrin form arginine-rich nuclear localization sequences that disrupt differentiation of keratinocytes. PMID: 12615358
    12. Barrier abnormality in loricrin keratoderma is linked to defective CE scaffold, resulting in increased extracellular permeability. PMID: 15102081
    13. ruled out as a candidate for the PSORS4 locus. PMID: 15598222
    14. report the clinical and molecular characterization of a new family with the recurrent 730insG LOR mutation, giving new insights in LK genotype-phenotype correlation PMID: 17953701
    15. results give evidence that heterogeneous phenotypes of LK may be the result of genetic heterogeneity of loricrin mutations, and demonstrate that nuclear accumulation of mutant loricrin is due to the nuclear targeting sequences in the mutant C-terminus. PMID: 18844868
    16. the deregulated increase in SPRR1A expression in chronic atopic skin lesions reflects an insufficient rise in SPRR transcripts, unable to compensate for the lack of LOR and thus contributing to the persistence of chronic atopic dermatitis skin lesions. PMID: 19672094

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  • 相關疾?。?/div>
    Vohwinkel syndrome with ichthyosis (VSI)
  • 亞細胞定位：
    Cytoplasm. Nucleus, nucleoplasm.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6663

    OMIM: 152445

    KEGG: hsa:4014

    STRING: 9606.ENSP00000357731

    UniGene: Hs.251680