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  4. Human Mammaglobin-A(SCGB2A2) ELISA kit

Human Mammaglobin-A(SCGB2A2) ELISA kit

  • 中文名稱(chēng)：
    人乳腺珠蛋白A(SCGB2A2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL020817HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人乳腺珠蛋白A(SCGB2A2)酶聯(lián)免疫試劑盒（CSB-EL020817HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的SCGB2A2含量。SCGB2A2是重要的肺部分泌蛋白，具有抗炎、免疫調(diào)節(jié)等作用。其表達(dá)異常與多種肺部疾病相關(guān)，如慢性阻塞性肺疾病、肺纖維化等。研究機(jī)制方面，主要聚焦于它在疾病發(fā)展中的作用、信號(hào)通路及作為治療靶點(diǎn)的潛力。試劑盒檢測(cè)范圍為0.312 ng/mL-20 ng/mL，適用于科研領(lǐng)域中對(duì)乳腺組織生理功能、疾病模型構(gòu)建、腫瘤微環(huán)境分析的蛋白表達(dá)水平檢測(cè)，也可用于體外培養(yǎng)體系或動(dòng)物實(shí)驗(yàn)中SCGB2A2動(dòng)態(tài)變化的定量分析，為探索其在乳腺疾病發(fā)生發(fā)展中的作用提供可靠工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    Mammaglobin 1 ELISA Kit; Mammaglobin-1 ELISA Kit; Mammaglobin-A ELISA Kit; MGB1 ELISA Kit; Scgb2a2 ELISA Kit; Secretoglobin family 2A member 2 ELISA Kit; SG2A2 ELISA Kit; SG2A2_HUMAN ELISA Kit; UGB2 ELISA Kit
  • 縮寫(xiě)：
    SCGB2A2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類(lèi)型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Others
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human SCGB2A2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %88
    Range %84-92
    1:2Average %90
    Range %86-94
    1:4Average %95
    Range %91-99
    1:8Average %97
    Range %93-102
  • 回收率：
    The recovery of human SCGB2A2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9793-102
    EDTA plasma (n=4)9085-95
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    202.704 2.617 2.661 2.534
    102.119 2.242 2.181 2.054
    51.806 1.704 1.755 1.628
    2.51.373 1.369 1.371 1.244
    1.250.928 0.864 0.896 0.769
    0.6250.545 0.519 0.532 0.405
    0.3120.287 0.257 0.272 0.145
    00.121 0.132 0.127 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. Results support a role for MGB1 in breast cancer malignancy in exchange for chemosensitivity. PMID: 26207726
    2. good coincidence was observed between primary and metastatic tumor GATA3 expression (kappa value = 0.826 >0.75) as compared with the coincidence of GCDFP15 (kappa value =0.492 <0.75) and mammaglobin (kappa value =0.593 <0.75) PMID: 28038704
    3. Expression of MGB1 was higher in breast cancer than non-malignant tissue and it decreased during breast cancer progression. PMID: 27563000
    4. trefoil factor 1 demonstrated breast specificity but was inferior to mammaglobin and GATA protein binding 3 PMID: 26276775
    5. Mammaglobin-A immunohistochemistry in primary central nervous system neoplasms and intracranial metastatic breast carcinoma. Cimino PJ Jr, Perrin RJ PMID: 23958549
    6. Overexpression of hMAM in breast cancer cells decreased migration and invasion, whereas knockdown of hMAM increased both. PMID: 24328556
    7. Mammaglobin immunohistochemistry is useful as a proxy marker for the ETV6-NTRK3 translocation in the diagnosis of salivary mammary analogue secretory carcinoma. PMID: 23773480
    8. High peripheral blood mammaglobin gene expression is associated with metastasis in breast cancer. PMID: 22897908
    9. Gross cystic disease fluid protein-15 and mammaglobin A expression determined by immunohistochemistry is of limited utility in triple-negative breast cancer. PMID: 22963676
    10. MGB1 was detected in endometrial tissue, with peak expression during the luteal phase, in 31% of endometriotic samples, in 53% of endometrial adenocarcinomas, and in 64% of breast carcinomas. PMID: 22994369
    11. Qualitative detection of plasma hMAM mRNA appears to be associated with unfavorable prognostic factors and lower rates of event-free survival in patients with breast cancer. PMID: 23212340
    12. Data show that HLA-A24-restricted, mammaglobin-A (Mam-A) derived, CD8(+) cytotoxic T lymphocyte (CTL) epitopes that can potentially be employed for Mam-A-based breast cancer vaccine therapy to breast cancer patients with HLA-A24 phenotype. PMID: 22074997
    13. A decrease in MGB1+mRNA levels (baseline-week 8) seemed to be associated with clinical response (P = 0.05). PMID: 21976532
    14. MGA detection by the modified nested RT-PCR is a specific marker for circulating tumor cells in patients with breast carcinoma and a negative prognostic factor for the disease PMID: 21939647
    15. High serum mammaglobin is associated with breast cancer. PMID: 21744998
    16. The current knowledge regarding the use of reverse-transcriptase PCR for detecting human mammaglobin mRNA as a biomarker for circulating tumor cells in breast cancer patients, is reviewed. PMID: 21473729
    17. The expression of hMAG was found to be increased with breast cancer grade. PMID: 21623075
    18. Most basal-like breast carcinomas and unclassified triple-negative carcinomas are negative for mammaglobin and gross cystic disease fluid protein 15. PMID: 21411781
    19. Detection of Mammaglobin as part of a 3-marker RT-PCR for early diagnosis of breast cancer. PMID: 20586026
    20. detection of mammaglobin mRNA is useful to determine the effect of therapy while maspin transcripts may indicate more aggressive disease. PMID: 20092039
    21. Expression of MGB1 transcript is associated with breast cancer PMID: 14696125
    22. MGB1 markers may be useful for identifying micrometastases in sentinel lymph nodes of breast cancer patients. PMID: 15151203
    23. Mammaglobin has a role in progression of breast cancer, as shown by its expression in leukapheresis products PMID: 15447988
    24. MGA protein exists in 2 main forms in breast neoplasms PMID: 15609337
    25. occult blood hMAM mRNA can be detected by RT-PCR and may have a role in progression of breast neoplasms PMID: 16110760
    26. mammaglobin expression is associated with expression of estrogen receptor and progesteron receptor in metastasizing breast cancer [letter] PMID: 16203799
    27. MGB1 transcript in peripheral blood of breast cancer patients was specific but with low sensitivity. MGB1 overexpression by itself or in combination with Ki67 might be considered an index of breast cancer rogression PMID: 16760290
    28. mammaglobin mRNA is expressed in breast cancer tissue PMID: 16761620
    29. Mammaglobin A is a highly specific molecular marker for the detection of circulating tumor cells in operable breast cancer, with important prognostic applications. PMID: 16925986
    30. MGB1 immunohistochemistry can serve as a differential marker of breast cancer metastasis from primary lung cancer. PMID: 17192791
    31. successfully generated MGB-specific CD4 T cell cultures and identified candidate MGB HLA class II epitopes PMID: 17653857
    32. The sensitivity of mammaglobin is equal or superior to that of GCDFP-15 for investigation of breast carcinoma. PMID: 18251583
    33. mammaglobin mRNA in peripheral blood may have a role in progression of breast cancer PMID: 18289390
    34. RT-PCR for hMAM test was more sensitive than cytomorphology of breast cancer derived pleural effusion. PMID: 18303409
    35. The overexpression of mammaglobin observed in certain breast tumors is an epiphenomenon not causally involved in breast carcinogenesis. PMID: 18630503
    36. This study demonstrated that human mammaglobin transcripts are expressed in the CSF of a BC patient with LM carcinomatosis. PMID: 18841443
    37. Breast cancer patients with pre-operative elevated bone marrow levels of Mammaglobin Aand/or trefoil factor 1 mRNA seem to constitute a small group of patients with a very poor prognosis. PMID: 18846421
    38. Both MGB1 and GCDFP-15 are specific markers for metastatic breast carcinomas in cell block fluid specimens (88 vs. 96%). PMID: 19217055
    39. Mammaglobin is a sensitive marker of breast carcinoma, it defines a subgroup of patients with better prognosis and is a useful method to detect breast cancer metastases. PMID: 19690758

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Secretoglobin family, Lipophilin subfamily
  • 組織特異性：
    Mammary gland specific. Over-expressed in breast cancer.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 7050

    OMIM: 605562

    KEGG: hsa:4250

    STRING: 9606.ENSP00000227918

    UniGene: Hs.46452