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  4. Human Mammaglobin-B(SCGB2A1) ELISA kit

Human Mammaglobin-B(SCGB2A1) ELISA kit

  • 中文名稱：
    人乳腺珠蛋白-B(SCGB2A1)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL020816HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人乳腺珠蛋白-B(SCGB2A1)酶聯(lián)免疫試劑盒（CSB-EL020816HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的SCGB2A1含量。試劑盒檢測(cè)范圍為0.235 ng/mL-15 ng/mL，適用于基礎(chǔ)科研中探索SCGB2A1在乳腺生理功能、腫瘤微環(huán)境互作或病理進(jìn)程中的生物學(xué)作用，例如通過檢測(cè)不同處理?xiàng)l件下細(xì)胞模型、動(dòng)物模型或臨床樣本中SCGB2A1的動(dòng)態(tài)變化，解析其在細(xì)胞增殖、分化或信號(hào)通路中的分子機(jī)制。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Lacryglobin ELISA Kit; LIPHC ELISA Kit; Lipophilin C ELISA Kit; Lipophilin-C ELISA Kit; LPHC ELISA Kit; LPNC ELISA Kit; Mammaglobin 2 ELISA Kit; Mammaglobin-2 ELISA Kit; Mammaglobin-B ELISA Kit; MGB2 ELISA Kit; MGC71973 ELISA Kit; Scgb2a1 ELISA Kit; Secretoglobin family 2A member 1 ELISA Kit; Secretoglobin; family 2A; member 1 ELISA Kit; SG2A1_HUMAN ELISA Kit; UGB3 ELISA Kit
  • 縮寫：
    SCGB2A1
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.235 ng/mL-15 ng/mL
  • 靈敏度：
    0.058 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Others
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human SCGB2A1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %94
    Range %90-99
    1:2Average %100
    Range %95-106
    1:4Average %90
    Range %85-94
    1:8Average %85
    Range %80-89
  • 回收率：
    The recovery of human SCGB2A1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9893-102
    EDTA plasma (n=4)9288-87
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    152.345 2.252 2.299 2.158
    7.51.723 1.676 1.700 1.559
    3.751.215 1.154 1.185 1.044
    1.880.721 0.743 0.732 0.591
    0.940.436 0.441 0.439 0.298
    0.470.302 0.288 0.295 0.154
    0.2350.234 0.219 0.227 0.086
    00.143 0.139 0.141
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.
  • 基因功能參考文獻(xiàn)：
    1. The expression of HOXB13, IL17BR, and mammaglobin 1 in sentinel lymph nodes predict the outcome of primary breast cancer patients. PMID: 29729704
    2. novel marker GATA3 stains a significantly higher proportion of both primary and metastatic breast carcinomas than GCDFP15 or mammaglobin with stronger and more diffuse staining, helpful in cases with small tissue samples PMID: 25906123
    3. The commonly used breast carcinoma biomarkers vary in their prognostic implications. GCDFP-15 independently indicated a favourable prognosis. GATA-3 and MGB were not associated with outcome. PMID: 25425335
    4. Results indicate that the quantitative analysis of h-MAM mRNA is a useful tool for detecting CTCs in breast cancer patients. PMID: 24706379
    5. Results indicated that SCGB2A1 represented a novel, prognostic factor for colorectal cancer, and its expression correlated with chemoresistance, radioresistance and cancer cell stemness. PMID: 24585249
    6. The data indicate that MGB1, MGB2 and LIPB mRNAs are expressed at low levels in human tissues but basal expression is upregulated in ovarian cancer. PMID: 24603286
    7. SCGB2A1 is a top differentially expressed gene in all major histological types of ovarian cancers. PMID: 23807163
    8. MGB has the highest expression in HER2-overexpressing breast cancers and may be a potentially useful marker for this subtype. PMID: 23332923
    9. Data show that plasma mammaglobin mRNA alone or in combination with CA15.3 (CD227) may be used as a valuable noninvasive approach for the diagnosis and the detection of metastasis in breast cancer at the time of diagnosis. PMID: 20306663
    10. The mammaglobin/lipophilin B complex is a promising diagnostic marker for breast cancer. PMID: 12022875
    11. MGB2 markers may be useful for identifying micrometastases in sentinel lymph nodes of breast cancer patients. PMID: 15151203
    12. SCGB 2A1 represents a new class of androgen target genes that are purely under indirect AR control mediated by DNA-bound Sp factors. PMID: 16020486
    13. Results indicate that mammaglobin, as measured by the ELISA, holds significant promise for breast cancer screening with the realistic potential to impact management of this disease. PMID: 16166429
    14. MGB-2 is highly expressed in endometrioid endometrial cancer [EEC], particularly in well- and moderately differentiated tumors, and may represent a novel molecular marker for EEC PMID: 18021217
    15. Expression levels of mammaglobins A and B in nasal polyps are not different between patients with and without AR PMID: 18416968
    16. MGB-2 expression characterizes less aggressive forms of EOC and is correlated with a favorable outcome PMID: 19635143

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Secretoglobin family, Lipophilin subfamily
  • 組織特異性：
    Expressed in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7051

    OMIM: 604398

    KEGG: hsa:4246

    STRING: 9606.ENSP00000244930

    UniGene: Hs.97644