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  4. Human Matrix metalloproteinase 10,MMP-10 ELISA kit

Human Matrix metalloproteinase 10,MMP-10 ELISA kit

  • 中文名稱：
    人基質金屬蛋白酶10(MMP-10)酶聯免疫試劑盒
  • 貨號：
    CSB-E04673h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人基質金屬蛋白酶10(MMP-10)酶聯免疫試劑盒（CSB-E04673h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的MMP10含量。MMP10 是重要靶點。它屬于基質金屬蛋白酶家族，在細胞外基質代謝、組織重塑等過程起關鍵作用。研究發(fā)現其異常表達與腫瘤侵襲轉移、炎癥等疾病密切相關，目前圍繞其開展的研究致力于闡明機制以開發(fā)針對性治療手段。試劑盒檢測范圍為78 pg/mL-5000 pg/mL，適用于基礎科研中探索MMP-10在疾病模型中的表達調控機制、藥物干預效果評估或病理微環(huán)境動態(tài)變化研究。滿足細胞實驗、動物模型及離體樣本的定量分析需求，為研究細胞外基質代謝相關通路提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Matrix metallopeptidase 10 (stromelysin 2) ELISA Kit; Matrix metalloprotease 10 ELISA Kit; Matrix metalloproteinase 10 (stromelysin 2) ELISA Kit; Matrix metalloproteinase 10 ELISA Kit; Matrix metalloproteinase-10 ELISA Kit; MMP 10 ELISA Kit; MMP-10 ELISA Kit; Mmp10 ELISA Kit; MMP10_HUMAN ELISA Kit; SL 2 ELISA Kit; SL-2 ELISA Kit; SL2 ELISA Kit; STMY 2 ELISA Kit; STMY2 ELISA Kit; Stromelysin 2 ELISA Kit; Stromelysin II ELISA Kit; Stromelysin-2 ELISA Kit; Stromelysin2 ELISA Kit; StromelysinII ELISA Kit; Transin 2 ELISA Kit; Transin-2 ELISA Kit; Transin2 ELISA Kit
  • 縮寫：
    MMP10
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    78 pg/mL-5000 pg/mL
  • 靈敏度：
    19.5 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human MMP-10 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 96
    Range % 90-102
    1:2 Average % 107
    Range % 102-110
    1:4 Average % 95
    Range % 90-101
    1:8 Average % 89
    Range % 86-96
  • 回收率：
    The recovery of human MMP-10 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 103 99-105
    EDTA plasma (n=4) 94 90-98
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    5000 1.899 1.877 1.888 1.779
    2500 1.354 1.366 1.360 1.251
    1250 0.924 0.966 0.945 0.836
    625 0.622 0.654 0.638 0.529
    312 0.433 0.455 0.444 0.335
    156 0.270 0.278 0.274 0.165
    78 0.238 0.233 0.236 0.127
    0 0.112 0.105 0.109 　
    .
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
  • 基因功能參考文獻：
    1. increased abundance of Snail and Axin2 is highly correlated to malignant transformation of OL, making them novel biomarker(s) predicting oral cancer development PMID: 28939077
    2. MMP10, either alone or in combination with tPA, might represent a new strategy for thrombolysis in ischemic stroke, providing higher protection against cerebrovascular damage. PMID: 28379489
    3. There is a significant association in the expression of P-Rex1 and MMP10 in human luminal breast cancer, and their co-expression is indicative of poor prognosis. PMID: 27351228
    4. MMP10 is a novel marker for cancer stem-like cells (CSCs)/cancer-initiating cells in epithelial ovarian cancer PMID: 27072580
    5. Data show that AJUBA upregulated MMP10 and MMP13 expression in esophageal squamous cell carcinoma (ESCC). PMID: 27172796
    6. MMP10 is overexpressed in the serum and pulmonary arteries of patients with systemic sclerosis-associated pulmonary hypertension. PMID: 28805015
    7. Using a quantum chemical approach method, it has been established that mutations in MMP-10 and FGA proteins led to substantial energetic modifications suggesting an impact on their functions and/or stability in the recurrent pregnancy loss patients. PMID: 29016666
    8. These results indicate that MMP10 serves a beneficial role in response to acute infection by moderating the proinflammatory response of resident and infiltrating macrophages. PMID: 27316687
    9. Mycobacterium tuberculosis activates inflammatory and stromal cells to secrete MMP-10, and this is partly driven by the virulence factor early secretory antigenic target-6. PMID: 27654284
    10. MMP10 expression is significantly upregulated in human masticatory mucosa during wound healing. PMID: 28005267
    11. Our results suggest that the level of the MMP-10 expression in tumor epithelium of cutaneous squamous cell carcinoma and basal cell carcinoma may contribute to the different invasive patterns observed in these tumors PMID: 27567711
    12. these results suggest that TGF-beta1 stimulates HSC-4 cell invasion through the Slug/Wnt-5b/MMP-10 signalling axis. PMID: 26861993
    13. the rs17435959 polymorphism of the MMP-10 gene may be associated with an increased risk of pelvic organ prolapse (POP). PMID: 26419737
    14. According to this study, the expression of ST-2 is associated with histopathological grade and tumor differentiation in head and neck squamous cell carcinomas. PMID: 26625808
    15. MMP-10 may be a novel biomarker reflecting both disease severity and prognosis in patients with idiopathic pulmonary fibrosis. PMID: 26415518
    16. Noncomplicated PVVs are associated with systemic, prothrombotic activation of hemostasis and increased concentration of MMP-10, suggesting a prothrombotic and proinflammatory state. PMID: 24413984
    17. Up-regulation of matrix metalloproteinase 10 is associated with colitis-associated cancer. PMID: 25742789
    18. hepatocellular carcinoma cells stably expressing MMP10 had increased CXCR4 expression and migratory capacity PMID: 25808184
    19. No association was found between MMP10 C/T rs486055 variants and anterior cruciate ligament rupture. PMID: 21410539
    20. Suggest that MMP-10 is associated with severity and poor outcome in peripheral arterial disease. PMID: 25441671
    21. Taken together, our findings show that MMP-10 can play a significant role in tumor growth and progression, and that MMP-10 perturbation may represent a rational strategy for cancer treatment. PMID: 24885595
    22. YY1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism. PMID: 24884523
    23. Preliminary evidence suggests that MMP-10 may be a mediator of the number of depressive phases during bipolar disorder PMID: 24576976
    24. Chrysin downregulates matrix metalloproteinase-10 in triple-negative breast cancer cells. PMID: 24122885
    25. Data suggest that MMP10 promotes differentiation of myoblasts into osteoblasts by up-regulating BMP2/Smad6/Smad7 (bone morphogenetic protein 2) signaling pathway and gene expression of proteins found in bone (collagen, type I; osterix; osteocalcin). PMID: 24077220
    26. MMP-10 is involved in the development of microvascular complications in type 1 diabetes and emerges as a potential therapeutic target for slowing down the evolution of diabetic nephropathy and retinopathy. PMID: 24078057
    27. Marked induction of matrix metalloproteinase-10 by respiratory syncytial virus infection in human nasal epithelial cells. PMID: 24009192
    28. rs17435959 of the MMP-10 gene is associated with carotid vulnerable plaque. PMID: 24327153
    29. serum proMMP-10 after acute ischemic stroke is associated with TNFalpha and may have a role in brain damage and poor outcome PMID: 23742289
    30. Small hairpin RNA silencing of proteinases overexpressed in diabetic corneas enhanced corneal epithelial and stem cell marker staining and accelerated wound healing. PMID: 24255036
    31. COOH truncation of the hepatitis B virus X protein, plays a role in enhancing cell invasiveness and metastasis in hepatocellular carcinoma by activating MMP10 through C-Jun. PMID: 22821423
    32. Findings suggest that MMP10 plays an important role in esophageal squamous cell carcinoma progression in the early stage, and overexpression of MMP10 in tumor tissues could be used as a potential prognostic marker in the early clinical stage of ESCC. PMID: 22121946
    33. High MMP-10 is associated with malignant pleural effusion. PMID: 22524815
    34. Analysis of gene expression data from human cancers reveals a strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types. PMID: 22545096
    35. Data show that TIMP-1 inhibits the MMP-10 with a K(i) of 1.1 x 10(-9) M, and TIMP-2 inhibits the MMP-10 with a K(i) of 5.8 x 10(-9) M. PMID: 22427646
    36. Thrombin/CD40L elicited a strong synergistic effect on endothelial MMP-10 expression and microparticles containing MMP-10 in vitro and in vivo, which may represent a new link between inflammation/thrombosis with prognostic implications. PMID: 22492089
    37. MMP-10 was capable of enhancing tissue plasminogen activator-induced fibrinolysis via a thrombin-activatable fibrinolysis inhibitor inactivation-mediated mechanism. PMID: 22104553
    38. the roles of MMP-10 in the invasion of head and neck squamous cell carcinoma cells in vitro PMID: 21998657
    39. Mmp10 is overexpressed in lung tumors induced by either the smoke carcinogen urethane or oncogenic Kras. PMID: 22022614
    40. Enhanced expression of MMP-10 is associated with progression from non-dysplastic Barrett's oesophagus to adenocarcinoma. PMID: 20584750
    41. Data demonstrate induction of MMP-10 by VEGF in HUVEC and support an angiogenic role for MMP-10 in response to VEGF stimulation in vitro and in vivo. PMID: 20432469
    42. Results suggest that MMP-10 may be important in the initial stages of squamous cell cancer progression and induced in the stroma relating to the general host-response reaction to skin cancer. PMID: 19601983
    43. MMP-10 and MMP-26, in particular, may associate with aggressive Merkel cell carcinoma. PMID: 19921252
    44. The catalytic domain of human matrix metalloproteinase-10 (MMP-10) has been expressed in Escherichia coli and its crystal structure solved at 2.1 angstroms resolution. PMID: 15095982
    45. Beta-carotene suppresses UVA-induction of MMP-10. PMID: 15288123
    46. a tightly regulated expression level of stromelysin-2 is required for limited matrix degradation at the wound site PMID: 15371548
    47. Overexpression of MMP-10 is associated with non-small cell lung cancer PMID: 15375490
    48. identified significant interactions between MMP10 (nt+180) polymorphisms and gender in abdominal aortic aneurysm PMID: 15944607
    49. zinc finger protein 267 as a negative transcriptional regulator of MMP-10 might promote liver fibrogenesis PMID: 16054593
    50. Increased levels of MMP-10 is associated with gastric cancer PMID: 16331256

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  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M10A family
  • 數據庫鏈接：

    HGNC: 7156

    OMIM: 185260

    KEGG: hsa:4319

    STRING: 9606.ENSP00000279441

    UniGene: Hs.2258