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  4. Human Matrix metalloproteinase-20(MMP20) ELISA kit

Human Matrix metalloproteinase-20(MMP20) ELISA kit

  • 中文名稱：
    人基質(zhì)金屬蛋白酶-20(MMP20)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL014667HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人基質(zhì)金屬蛋白酶-20(MMP20)酶聯(lián)免疫試劑盒（CSB-EL014667HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的MMP20含量。MMP20 即基質(zhì)金屬蛋白酶 20，在牙釉質(zhì)發(fā)育中起關(guān)鍵作用。其研究機(jī)制主要聚焦于參與牙釉質(zhì)蛋白水解、調(diào)控釉質(zhì)礦化過程等方面。對它的深入研究有助于理解牙釉質(zhì)形成機(jī)理，為牙釉質(zhì)發(fā)育異常相關(guān)疾病的診治提供思路。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，牙齒發(fā)育相關(guān)疾病機(jī)制研究、口腔組織工程及病理過程分析、牙釉質(zhì)發(fā)育調(diào)控、口腔疾病模型構(gòu)建、生物材料降解評估、細(xì)胞生物學(xué)、組織工程及疾病機(jī)制等領(lǐng)域的科研需求本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    AI2A2 ELISA Kit; Enamel metalloproteinase ELISA Kit; Enamelysin ELISA Kit; Matrix metalloproteinase 20 ELISA Kit; Matrix metalloproteinase-20 ELISA Kit; MMP 20 ELISA Kit; MMP-20 ELISA Kit; MMP20 ELISA Kit; MMP20_HUMAN ELISA Kit
  • 縮寫：
    MMP20
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human MMP20 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 89
    Range % 85-93
    1:2 Average % 100
    Range % 95-105
    1:4 Average % 86
    Range % 83-89
    1:8 Average % 97
    Range % 92-101
  • 回收率：
    The recovery of human MMP20 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 88 86-90
    EDTA plasma (n=4) 101 97-104
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    20 2.303 2.204 2.254 2.101
    10 1.915 1.964 1.940 1.787
    5 1.636 1.530 1.583 1.430
    2.5 1.201 1.301 1.251 1.098
    1.25 0.821 0.835 0.828 0.675
    0.625 0.512 0.501 0.507 0.354
    0.312 0.352 0.368 0.360 0.207
    0 0.154 0.152 0.153 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site.
  • 基因功能參考文獻(xiàn)：
    1. The levels of MMP20 silencing-induced downregulation differed amongst CSC markers, with ABCG2 and CD44 showing more pronounced downregulations. PMID: 30002682
    2. common variants at 11q22.2 within MMP20 associate with neuroblastoma cases harboring 11q deletion (rs10895322) PMID: 28924153
    3. The article data showed that MMP20 rs1784418 C>T (Matrix metalloproteinase 20) appears to protect against dental caries, but its effects are likely to be more marked in certain populations. PMID: 27992873
    4. DSPP-MMP20 pair may play a role in the normal turnover of cell surface proteins and/or repair of pericellular matrix proteins of the basement membranes in the metabolically active duct epithelial system of the nephrons. PMID: 27666430
    5. Levels of matrix metalloproteinases MMP-19 and MMP-20 expression are significantly increased in pancreatic ductal adenocarcinoma (PDAC). PMID: 26692439
    6. The expression of MMP20 was lower in calcifying cystic odontogenic tumor when compared to all tumors and cysts. PMID: 26558991
    7. The growth of choroidal neovascularization in AMD would be affected by 2 genes: MMP20, a newly confirmed gene expressed in the retina, and ARMS2/HTRA1, a well-known susceptibility gene for AMD. PMID: 26337002
    8. Novel homozygous mutation MMP20 (c.1054G>A, p.Glu352Lys) genes were identified in amelogenesis imperfect consanguinity. Mutant MMP20 was expressed at a normal level but secreted only minimally with proteolytic function. PMID: 26124219
    9. expression of MMP-20 and co-expression and potential interaction with DSPP in human major salivary gland tissues PMID: 25805840
    10. The results identify MMP-20 as a broad activator of pro-KLKs, suggesting the potential for intersection of the KLK and MMP axes under pathological dysregulation of MMP-20 expression. PMID: 23241590
    11. Polymorphisms of MMP7 and MMP20 genes may be surrogate markers to predict long-term outcomes after kidney transplantation. PMID: 23953525
    12. mineralized content slightly decreased; magnesium substituting for calcium in crystal. anomalies affected enamel with minimal interrod enamel; apatite crystals perpendicular to enamel prisms, suggesting possible new role for MMP20 in enamel formation. PMID: 23625376
    13. amelogenesis imperfecta-causing mutations were identified in three of the probands: 2)a novel missense transition mutation in both MMP20 alleles (g.15390A>G; c.611A>G; p.His204Arg) that substituted arginine for histidine. PMID: 23355523
    14. Variation in MMP20 may be associated with caries experience mainly in Caucasian subjects with poor oral health habits. PMID: 22330321
    15. hypocalcified amelogenesis imperfecta, Witkop type III, was unrelated to previously described mutations in the ENAM or MMP-20 genes PMID: 21504268
    16. MMP-20 is overexpresssed in LSCC compared with the adjacent normal laryngeal epithelium. PMID: 21466263
    17. Associations between tooth agenesis and MMP1 (p=0.007), and MMP20 (p=0.03) were found in Brazilian families. MMP20 continued to be associated with tooth agenesis (p=0.01). Mmp20 was not expressed during the initial stages of tooth development. PMID: 21144496
    18. Enamelysin and collagen XVIII were co-localized in the developing enamel matrix and stratum intermedium and in the enamel-like tumor matrix of odontogenic tumors. PMID: 15296943
    19. A mutation in the MMP-20 gene has been identified and associated with amelogenesis imperfecta. PMID: 15744043
    20. c-Jun is a key regulatory element for MMP-20 expression PMID: 17611094
    21. Binding of the P41T mutant amelogenin for matrix metalloproteinase 20 was significantly lower than that of wild-type amelogenin. PMID: 18434575
    22. A total of 463 individuals from 54 families were evaluated and mutations in the AMEL, ENAM and KLK4 genes were identified. PMID: 18714142
    23. were able to find SNPs in the matrix metallopeptidase gene MMP20(GeneID 9313) that are significantly associated with kidney aging. PMID: 19834535
    24. In a family with a hypomaturation-type enamel defect, mutational and haplotype analyses revealed an amelogenesis imperfecta-causing point mutation in exon 6 of MMP20 that results in a single amino acid substitution in the hemopexin domain. PMID: 19966041

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  • 相關(guān)疾?。?/div>
    Amelogenesis imperfecta, hypomaturation type, 2A2 (AI2A2)
  • 亞細(xì)胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M10A family
  • 組織特異性：
    Expressed specifically in the enamel organ.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7167

    OMIM: 604629

    KEGG: hsa:9313

    STRING: 9606.ENSP00000260228

    UniGene: Hs.591946