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  4. Human Matrix metalloproteinase-28(MMP28) ELISA kit

Human Matrix metalloproteinase-28(MMP28) ELISA kit

  • 中文名稱：
    人基質(zhì)金屬蛋白酶-28(MMP28)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL014675HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人基質(zhì)金屬蛋白酶-28(MMP28)酶聯(lián)免疫試劑盒（CSB-EL014675HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的MMP28含量。MMP28即基質(zhì)金屬蛋白酶 28，在組織修復(fù)、免疫調(diào)節(jié)等方面有重要作用。其研究機(jī)制主要聚焦于它對細(xì)胞外基質(zhì)的降解及調(diào)節(jié)，參與維持組織穩(wěn)態(tài)。還探究其在腫瘤等疾病進(jìn)程里的作用，有望為相關(guān)疾病診治提供新方向。試劑盒檢測范圍為0.625 ng/mL-40 ng/mL，本試劑盒可滿足基礎(chǔ)科研領(lǐng)域?qū)MP28蛋白水平的定量分析需求，例如探索其在組織修復(fù)模型、慢性炎癥機(jī)制或疾病相關(guān)信號通路中的動態(tài)變化，為分子生物學(xué)、細(xì)胞功能研究及疾病機(jī)制解析提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Epilysin ELISA Kit; Matrix metalloproteinase 28 ELISA Kit; Matrix metalloproteinase-28 ELISA Kit; MM 28 ELISA Kit; MM28 ELISA Kit; MMP 25 ELISA Kit; MMP 28 ELISA Kit; MMP-28 ELISA Kit; MMP25 ELISA Kit; MMP28 ELISA Kit; MMP28_HUMAN ELISA Kit
  • 縮寫：
    MMP28
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.625 ng/mL-40 ng/mL
  • 靈敏度：
    0.156 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Can degrade casein. Could play a role in tissues homeostasis and repair.
  • 基因功能參考文獻(xiàn)：
    1. Circulating MMP-28 was elevated in atrial fibrillation PMID: 29729262
    2. Results suggest a crucial role of MMP9 at the early stage of carcinogenesis in the large intestine. The increase in MMP9 and TIMP1 mRNA concentration and the decrease in MMP28 in the large intestinal tissue may be a confirmation of cancer. PMID: 28293015
    3. These results proved for the first time that epilysin expression was significantly elevated in glioblastoma PMID: 25429835
    4. A decreased level of IL-33 and an elevated concentration of MMP-28 were found in coronary heart disease patients and correlated with disease severity. PMID: 24710352
    5. MMP28 mRNA expression is highest in healthy tissues when compared to diseased periodontal tissues. PMID: 24167355
    6. Data established a seven-gene (AR, ESR2, GATA3, GBX2, KRT16, MMP28 and WNT11) prognostic signature to define a subset of triple-negative breast cancer (TNBC). PMID: 23549873
    7. Over-expression of MMP28 provides protection against apoptosis induced by either serum-deprivation or treatment with a protein kinase inhibitor. PMID: 22040290
    8. Gene expression of MMP28 in the intervertebral disk is not regulated by inflammatory mechanisms, is donor-dependent and cannot be positively or negatively linked to the grade of degeneration and only weakly to the occurrence of trauma. PMID: 21801383
    9. basal expression of MMP-2, MMP-9, MMP-28, and Filaggrin was evaluated in oral keratinocytes to collect information about ability of cigarette smoke to modify basal expression pattern of these key enzymes in the absence of clinical signs in oral epithelium PMID: 21723775
    10. MMP28 is frequently overexpressed during progression of gastric carcinoma, and contributes to tumor cell invasion and metastasis. PMID: 21615884
    11. Findings presented here show the first documentation of intervertebral disc expression and production of MMP28 PMID: 20003223
    12. MMP28 gene expression is regulated by Sp1 transcription factor acetylation. PMID: 20144149
    13. Expression of MMP-21 and MMP-28 seems to associate with the Merkel cell carcinoma of lesser malignant potential. PMID: 19921252
    14. Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. PMID: 12164918
    15. Results suggest inhibition of MMP-28 may be beneficial under conditions of dysmyelination. PMID: 18778487
    16. Data demonstrate that expression of MMP28 alters keratinocyte phenotype towards a more adhesive, less migratory behaviour. PMID: 19375502
    17. Epilysin (MMP-28) is deposited to the basolateral extracellular matrix of epithelial cells. PMID: 19379669

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  • 亞細(xì)胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M10A family
  • 組織特異性：
    Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14366

    OMIM: 608417

    KEGG: hsa:79148

    STRING: 9606.ENSP00000250144

    UniGene: Hs.380710