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  4. Human Mitochondrial import inner membrane translocase subunit TIM14(DNAJC19) ELISA kit

Human Mitochondrial import inner membrane translocase subunit TIM14(DNAJC19) ELISA kit

  • 中文名稱：
    人線粒體進(jìn)口內(nèi)膜轉(zhuǎn)位酶亞基TIM14(DNAJC19)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL007026HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人線粒體進(jìn)口內(nèi)膜轉(zhuǎn)位酶亞基TIM14(DNAJC19)酶聯(lián)免疫試劑盒（CSB-EL007026HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的DNAJC19含量。DNAJC19是一種基因，作為治療非小細(xì)胞肺癌的靶點(diǎn)。研究發(fā)現(xiàn)，該基因參與NSCLC細(xì)胞的增殖和遷移，通過抑制其表達(dá)可以有效降低腫瘤細(xì)胞的侵襲、遷移和生長能力，成為NSCLC患者的潛在治療靶標(biāo)。試劑盒檢測范圍為28 pg/mL-1800 pg/mL，通過高特異性抗體對靶蛋白進(jìn)行精準(zhǔn)捕獲與信號放大，可為線粒體蛋白質(zhì)轉(zhuǎn)運(yùn)機(jī)制研究、疾病模型中線粒體功能障礙評估以及藥物干預(yù)效果分析提供可靠工具，廣泛應(yīng)用于神經(jīng)退行性疾病、心血管疾病等科研領(lǐng)域的分子機(jī)制探索及生物標(biāo)志物定量分析。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    DnaJ (Hsp40) homolog; subfamily C; member 19 ELISA Kit; DnaJ homolog subfamily C member 19 ELISA Kit; DNAJC19 ELISA Kit; homolog of yeast TIM14 ELISA Kit; Mitochondrial import inner membrane translocase subunit TIM14 ELISA Kit; PAM18 ELISA Kit; TIM 14 ELISA Kit; TIM14 ELISA Kit; TIM14_HUMAN ELISA Kit; TIMM 14 ELISA Kit; TIMM14 ELISA Kit; translocase of the inner mitochondrial membrane 14 ELISA Kit; Translocase of the inner mitochondrial membrane 14; yeast homolog of ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    28 pg/mL-1800 pg/mL
  • 靈敏度：
    7 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human DNAJC19 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %97
    Range %92-101
    1:2Average %86
    Range %81-90
    1:4Average %93
    Range %89-98
    1:8Average %90
    Range %85-94
  • 回收率：
    The recovery of human DNAJC19 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 10399-107
    EDTA plasma (n=4)9590-100
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    18002.656 2.719 2.688 2.579
    9002.287 2.172 2.230 2.121
    4501.653 1.707 1.680 1.571
    2251.135 1.071 1.103 0.994
    112.50.681 0.653 0.667 0.558
    560.374 0.362 0.368 0.259
    280.257 0.252 0.255 0.146
    00.112 0.105 0.109
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling. May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.
  • 基因功能參考文獻(xiàn)：
    1. Both DnaJC15 and DnaJC19 formed two distinct subcomplexes with Magmas at the import channel. PMID: 27330077
    2. The loss of DNAJC19/PHB complexes affects cardiolipin acylation and leads to the accumulation of cardiolipin species with altered acyl chains. PMID: 24856930
    3. A report of a new mutation in the human DNAJC19 gene that causes early onset dilated cardiomyopathy syndrome in two brothers of Finnish origin. PMID: 22797137
    4. The association of dilated cardiomyopathy with ataxia (DCMA) syndrome with a segment of 3q26.33 and the identification of a splice mutation in a novel gene DNAJC19 in DCMA patients. PMID: 16055927
    5. Dilated cardiomyopathy caused by homozygous mutations in a novel gene, DNAJC19, presumed to play a role in importation of mitochondrial proteins. PMID: 17244376

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  • 相關(guān)疾?。?/div>
    3-methylglutaconic aciduria 5 (MGA5)
  • 亞細(xì)胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
  • 蛋白家族：
    TIM14 family
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30528

    OMIM: 608977

    KEGG: hsa:131118

    STRING: 9606.ENSP00000372005

    UniGene: Hs.230601