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  4. Human Mucin-15(MUC15) ELISA kit

Human Mucin-15(MUC15) ELISA kit

  • 中文名稱：
    人粘蛋白-15(MUC15)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL015218HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人粘蛋白-15(MUC15)酶聯(lián)免疫試劑盒（CSB-EL015218HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的MUC15含量。MUC15屬于黏蛋白家族成員，在多種組織中表達(dá)。它參與細(xì)胞黏附、信號(hào)傳導(dǎo)等過程。研究發(fā)現(xiàn)其異常表達(dá)與腫瘤發(fā)生、發(fā)展相關(guān)，可能通過調(diào)節(jié)腫瘤細(xì)胞增殖、侵襲和轉(zhuǎn)移發(fā)揮作用，有望成為腫瘤治療的新靶點(diǎn)。試劑盒檢測(cè)范圍為125 pg/mL-8000 pg/mL，該產(chǎn)品適用于科研領(lǐng)域?qū)UC15蛋白表達(dá)水平的定量分析，例如在癌癥發(fā)生機(jī)制、炎癥相關(guān)通路研究或組織特異性表達(dá)譜分析中評(píng)估生物樣本中MUC15的動(dòng)態(tài)變化，為探索其在細(xì)胞通訊、疾病生物標(biāo)志物篩選等基礎(chǔ)研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Component II ELISA Kit; Glycoprotein 4 ELISA Kit; Glycoprotein C ELISA Kit; MUC 15 ELISA Kit; MUC-15 ELISA Kit; Muc15 ELISA Kit; MUC15_HUMAN ELISA Kit; Mucin 15 ELISA Kit; Mucin 15 cell surface associated ELISA Kit; Mucin-15 ELISA Kit; PAS3 ELISA Kit; PASIII ELISA Kit
  • 縮寫：
    MUC15
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測(cè)范圍：
    125 pg/mL-8000 pg/mL
  • 靈敏度：
    31.25 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human MUC15 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 97
    Range % 89-103
    1:2 Average % 95
    Range % 90-99
    1:4 Average % 97
    Range % 87-102
    1:8 Average % 103
    Range % 97-108
  • 回收率：
    The recovery of human MUC15 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 86 81-90
    EDTA plasma (n=4) 92 88-98
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    8000 1.972 2.027 2.000 1.863
    4000 1.456 1.436 1.446 1.309
    2000 0.902 0.925 0.914 0.777
    1000 0.576 0.583 0.580 0.443
    500 0.430 0.421 0.426 0.289
    250 0.317 0.309 0.313 0.176
    125 0.250 0.242 0.246 0.109
    0 0.140 0.134 0.137 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May play a role in the cell adhesion to the extracellular matrix.
  • 基因功能參考文獻(xiàn)：
    1. Frameshift mutations of MUC15 gene is associated with gastric and colorectal cancers. PMID: 25573589
    2. Multivariate analysis suggested that MUC15 overexpression was an independent factor for prognosis (hazard risk: 3.216; P=0.009). It was concluded that MUC15 is overexpressed in glioma tissues. PMID: 24710941
    3. MUC15 inhibits dimerization of EGFR and PI3K-AKT signaling and is associated with aggressive hepatocellular carcinomas in patients. PMID: 23933603
    4. MUC15 is a strong candidate for eczema. PMID: 22657408
    5. MUC4 and MUC15 were overexpressed in papillary thyroid carcinoma, and high MUC15 expression was associated with high malignant potential. PMID: 21615302
    6. MUC15 was expressed most highly in human placenta. MUC15 mRNA & protein increased with gestational age (P < 0.05, 1st versus 3rd trimester). Differential expression of MUC15 in human placentas may play critical role in regulation of trophoblast invasion. PMID: 17720698
    7. Overexpression of MUC15 activates extracellular signal-regulated kinase 1/2 and promotes the oncogenic potential of colon cancer cells. PMID: 19520792

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  • 亞細(xì)胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 組織特異性：
    Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, bone marrow, lymph node and lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14956

    OMIM: 608566

    KEGG: hsa:143662

    STRING: 9606.ENSP00000416753

    UniGene: Hs.407152