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  4. Human Myelin P2 protein (PMP2) ELISA kit

Human Myelin P2 protein (PMP2) ELISA kit

  • 中文名稱：
    人髓磷脂P2蛋白(PMP2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E09601h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人髓磷脂P2蛋白(PMP2)酶聯(lián)免疫試劑盒（CSB-E09601h）檢測(cè)樣本中的PMP2含量。本試劑盒適用于多種生物樣本的檢測(cè)（具體適用樣本類型需根據(jù)實(shí)驗(yàn)需求確認(rèn)）；可滿足基礎(chǔ)科研中PMP2蛋白表達(dá)水平分析、疾病模型機(jī)制探究以及藥物干預(yù)效果評(píng)估等需求，例如在吉蘭 - 巴雷綜合征、Charcot - Marie - Tooth病等神經(jīng)病變研究中的應(yīng)用。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    FABP8 ELISA Kit; M FABP ELISA Kit; MP2 ELISA Kit; Myelin FABP ELISA Kit; Myelin P2 protein ELISA Kit; MYP2_HUMAN ELISA Kit; P2 ELISA Kit; Peripheral myelin protein 2 ELISA Kit; PMP2 ELISA Kit
  • 縮寫(xiě)：
    PMP2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 檢測(cè)范圍：
    Request Information
  • 靈敏度：
    Request Information
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
  • 基因功能參考文獻(xiàn)：
    1. The structural characterization of the F57A mutant of P2 which shows changes in the portal region and helix alpha2 and an unfolded status upon lipid bilayer binding. Further results suggest a central role for Phe57 in regulating the opening of the portal region in human P2, and the F57A mutation disturbs dynamic cross-correlation networks in the portal region of P2. PMID: 29940944
    2. SH3TC2, PMP2, and BSCL2 pathogenic variants might be rare in Chinese Charcot-Marie-Tooth (CMT) patients. PMID: 29336362
    3. Our genetic and clinical findings in these kindred demonstrate that dominant PMP2 mutations cause Charcot-Marie- Tooth disease type 1. PMID: 27009151
    4. A fully deuterated sample of myelin P2 protein was produced identifying the neutron crystal structure. PMID: 26527266
    5. This report might expand the genetic and clinical features of Charcot-Marie-Tooth disease and a further mechanism study will enhance our understanding of PMP2-associated peripheral neuropathy. PMID: 26828946
    6. The structure of human P2 refined at the ultrahigh resolution of 0.93 A allows detailed structural analyses, including the full organization of an internal hydrogen-bonding network. PMID: 24419389
    7. the structure and function of the P2 protein from human myelin, which is able to bind both monomeric lipids inside its cavity and membrane surfaces PMID: 20421974

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9117

    OMIM: 170715

    KEGG: hsa:5375

    STRING: 9606.ENSP00000256103

    UniGene: Hs.571512